Trends in anemia treatment with erythropoietin usage and patient outcomes
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Anesthesia for Patients with Concomitant Cardiac and Renal Dysfunction
2016, Anesthesiology ClinicsCitation Excerpt :Since the introduction of recombinant erythropoietin for the treatment of ESRD-related anemia in 1989, much work has been directed toward determining the appropriate degree of hemoglobin (Hgb) correction. Multiple clinical benefits have been associated with correcting hematocrit to greater than 30% in patients with ESRD, including improved quality of life, exercise capacity, and cardiac function.8,9 Although increasing hematocrit to greater than 30% was associated with important benefits, other data suggest that when higher hematocrit levels are targeted, the risks outweigh the benefits.10
The role of the chronic kidney disease clinic
2010, Chronic Kidney Disease, Dialysis, and Transplantation: A Companion to Brenner and Rector's The Kidney - Expert Consult: Online and PrintThe Role of the Chronic Kidney Disease Clinic
2010, Chronic Kidney Disease, Dialysis, and TransplantationRole of Interleukin-6 in the Anemia of Chronic Disease
2009, Seminars in Arthritis and RheumatismCitation Excerpt :Several acute-phase reactants have been linked to erythropoietin resistance in ESRD, including markers of inflammation and iron storage (Table 3). Inflammatory cytokines, including IL-6, appear to blunt the response to erythropoietin in patients with ESRD (33,34). CRP is an acute phase protein synthesized by the liver in response to inflammation, which is transcriptionally regulated by IL-6.
Sunset for statins after AURORA?
2009, New England Journal of MedicineClinical paradigms - Anemia of chronic disease: A harmful disorder or an adaptive, beneficial response?
2008, CMAJ. Canadian Medical Association Journal