Elsevier

Annals of Emergency Medicine

Volume 17, Issue 11, November 1988, Pages 1148-1157
Annals of Emergency Medicine

Special contribution
Reperfusion injury of postischemic tissues

https://doi.org/10.1016/S0196-0644(88)80060-XGet rights and content

Reperfusion injury, occurring when blood circulation is restored to previously ischemic tissues, is now demonstrable as a pathophysiologic entity distinct from the primary ischemic injury that develops during ischemia per se. The primary pathogens that cause reperfusion injury are thought to be partially reduced oxygen species, including superoxide radicals, hydrogen peroxide, and hydroxyl radicals, which initiate lipid peroxidation and other deleterious oxidation reactions during the reperfusion period. Antioxidant drugs, given at the end of ischemia or at the very onset of reperfusion, can improve the postischemic function of isolated organs and the survival of intact animals subject to a cycle of circulatory arrest and reperfusion, suggesting that reperfusion injury is both a real and a preventable pathophysiologic entity.

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    This study was supported by Grants HL-36712 and HL-35996 from the National Heart, Lung, and Blood Institute, and by Grant CA-38144 from the National Cancer Institute, US Public Health Service, Bethesda, Maryland.

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