Trends in Pharmacological Sciences
ViewpointAnimal models of acute ischaemic stroke: can they predict clinically successful neuroprotective drugs?
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Neurobehavioural deficits correlate with the cerebral infarction volume of stroke animals: A comparative study on ischaemia-reperfusion and photothrombosis models
2012, Environmental Toxicology and PharmacologyCitation Excerpt :The advantages of MCAO model are the availability of techniques for both permanent and reversible occlusion, the long history of model study and the fact that the majority of human ischaemic strokes result from an occlusion in the region of the MCA. Disadvantages of the model are the large size of the infarcts, the need for extensive surgery, and the marked variability in the damage (Hunter et al., 1995). One of the most attractive and relatively non-invasive models is the photochemically induced stroke model.
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2012, Coordination Chemistry ReviewsCitation Excerpt :Since oxidative stress has a recognized main role in the pathogenesis of neurodegenerative diseases, treatments targeting sources of ROS have attracted particular attention [128]. In fact, both anti-oxidants and iron chelating agents have shown neuroprotective efficacy in animal models of AD and PD [129] In particular, the HPs, by chelating the labile iron, can act as antioxidants and thus reduce oxidative stress [130].
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