Short communicationTranslocation (2;11)(q31;q12) is recurrent in collagenous fibroma (desmoplastic fibroblastoma)
Introduction
Collagenous fibroma (desmoplastic fibroblastoma) is a fibrous soft tissue tumor first described by Evans in 1995 [1]. This benign tumor typically arises in the subcutaneous tissue or skeletal muscle of adults, usually in the fifth or sixth decade. Men are affected four times more commonly than women. Collagenous fibroma has a wide anatomic distribution, and presents as a slowly growing, painless mass, ranging from 1 to 20 cm in maximum dimension [2]. Surgery is the treatment of choice, with no reported tumor recurrences. Histopathologically, collagenous fibroma must be distinguished from desmoid tumor.
Reportedly, only two cases of collagenous fibroma have been subjected to cytogenetic analysis [3]. A cytogenetically abnormal clone involving the 11q12 breakpoint was detected in both of these cases. We describe the cytogenetic findings of an additional case of collagenous fibroma.
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Materials and methods
The patient was a 55-year-old man who noted a painless supraclavicular mass while showering. The mass appeared fixed to deep structures without neurologic deficit. Magnetic resonance imaging revealed a fusiform mass posterior to the brachial plexus in intimate association with the dome of the right rib cage. The lesion was resected by incising the insertion of the trapezius muscle to provide access to the supraclavicular fossa. Grossly, the tumor was well circumscribed, solid, fibrous, and
Results
The following abnormal clone was detected in 14 of 20 metaphase cells examined: 46,XY,t(1;3)(p31;q21),t(2;11) (q31;q12) (Fig. 2).
Discussion
Collagenous fibroma is a recently defined entity, with fewer than 100 reported cases [1], [2], [3], [6], [7], [8], [9]. The histologic diagnosis rests on recognition of spindle- to stellate-shaped fibroblasts and myofibroblasts embedded in an abundant, amorphous collagenous background. The differential diagnosis includes other bland spindle-cell proliferations, such as fibroma of tendon sheath, desmoid tumor, nodular fasciitis, and extrapleural solitary fibrous tumor.
Only two cases of
Acknowledgements
The authors would like to thank Dr. Warren Sanger for his valuable comments and Patty Cattano for her expert technical assistance. This work was supported in part by grants from John A. Wiebe Children's Health Care Fund, National Institutes of Health/National Cancer Institute (P30 CA 36727), and the Nebraska State Department of Health (LB595).
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2017, Annals of Diagnostic PathologyCitation Excerpt :Desmoplastic fibroblastomas (collagenous fibromas) are also sparsely to paucicellular lesions composed of patternless distributions of spindle and stellate fibroblasts within hypovascular, prominently fibrous stroma. These lesions can be focally positive for SMA [83-86], and are associated with a characteristic translocation (2;11)(q31;q12) [87]. Superficial angiomyxomas can show variable cellularity and contain prominent vasculature and resemble superficial LGFMS;(20) however, in contrast, these can contain acellular mucin pools and muciphages, and often neutrophils amongst their sparse inflammatory mixed infiltrate, as well as sometimes intermingled epithelial structures, including squamous epithelial strands, epidermoid cysts and buds of basaloid cells [88,89].
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