I searched the PubMed and Google Scholar databases up to August, 2010, and the International Glaucoma Review Abstracts (2005 to 2010), with the following search terms: “glaucoma”, “angle closure”, “open angle”, “pathogenesis”, “diagnosis”, “treatment”, “laser”, “surgery”, “genetics”, “childhood”, “secondary”, and “neovascular”, both alone and in combinations. I mostly selected publications from the past 5 years, but did not exclude important older publications. I also searched the reference
SeminarGlaucoma
Section snippets
Clinical definitions
In 2002, an international consensus panel published definitions of open-angle glaucoma and angle-closure glaucoma that are now widely accepted.1, 2 For both disorders, glaucoma is now recognised to be an optic neuropathy and is thought to be present only when at least one eye has both typical structural and functional defects (optic disc damage and visual field loss). This combination of damage has to be sufficiently characteristic to indicate the death of a substantial number of retinal
Clinical features and risk factors
Open-angle glaucoma is distinguished from other optic neuropathies by slow progression over months to years.11 The clinical appearance of this form of glaucoma is distinguishable from ischaemic optic neuropathy12 or chiasmal tumour-induced neuropathy by the excavation or abnormal structural deepening of optic-disc connective tissue. Of retinal neurons, glaucoma affects only retinal ganglion cells13, 14—a loss that occurs selectively more rapidly in axons that pass through the upper and lower
Clinical features, risk factors, and pathogenesis
Although angle-closure glaucoma is often related to an acute, painful crisis associated with blurred vision, more than 75% of patients do not have an acute attack,80 instead they have an asymptomatic course with progressive loss of the visual field similar to that in patients with open-angle glaucoma. Worldwide, a third of patients with primary glaucoma have angle-closure glaucoma.1 The proportionate vision loss in angle-closure glaucoma might be as much as twice as great as open-angle
Other forms of glaucoma
Glaucoma is uncommon in children, with an estimated prevalence in the USA of fewer than three per 100 000 for all forms of glaucoma in those younger than 20 years.100 Many of these cases are primary childhood-onset glaucoma, which presents during the first year of life with symptoms of tearing and photophobia and signs of enlarged and cloudy corneas. There is substantial heritability, and three genetic loci have been identified for childhood glaucoma, with one gene clearly associated with the
Conclusions
Both open-angle and angle-closure glaucoma are commonly present in older people and, with the ageing of world populations, the number with both forms of glaucoma will substantially increase in the next decade.1 The diagnosis of glaucoma of each type requires a detailed eye examination, with tests of both structure and function of the eye. New developments in diagnostic testing might soon make this process more efficient. Therapy that lowers intraocular pressure slows the progress of open-angle
Search strategy and selection criteria
References (106)
- et al.
The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage
Prog Retin Eye Res
(2005) - et al.
Risk factors for open-angle glaucoma in a Japanese population: the Tajimi study
Ophthalmology
(2006) - et al.
Natural history of open-angle glaucoma
Ophthalmology
(2009) - et al.
Five-year incidence of open-angle glaucoma: the visual impairment project
Ophthalmology
(2002) - et al.
Primary open-angle glaucoma in Blacks: a review
Surv Ophthalmol
(2003) - et al.
Risk of glaucoma in ocular hypertension with and without pseudoexfoliation
Ophthalmology
(2005) Central corneal thickness—tonometry artifact, or something more?
Ophthalmology
(2007)- et al.
Predictors of long-term progression in the Early Manifest Glaucoma Trial
Ophthalmology
(2007) - et al.
Mouse genetic models: an ideal system for understanding glaucomatous neurodegeneration and neuroprotection
Prog Brain Res
(2008) - et al.
Biomechanics of the optic nerve head
Exp Eye Res
(2009)
Risk factors for glaucoma onset and progression
Surv Ophthalmol
Blood flow in glaucoma discussion. Blood pressure, perfusion pressure, and glaucoma
Am J Ophthalmol
Disc hemorrhages and treatment in the early manifest glaucoma trial
Ophthalmology
Baculoviral IAP repeat-containing-4 protects optic nerve axons in a rat glaucoma model
Mol Ther
Efficacy and safety of memantine, an NMDA-type open-channel blocker, for reduction of retinal injury associated with experimental glaucoma in rat and monkey
Surv Ophthalmol
Morphological and functional retinal impairment in Alzheimer's disease patients
Clin Neurophysiol
Community screening for eye disease by laypersons: the Hoffberger program
Am J Ophthalmol
Incidence and rates of visual field progression after longitudinally measured optic disc change in glaucoma
Ophthalmology
Diagnostic tools for glaucoma detection and management
Surv Ophthalmol
A comparison of visual field progression criteria of 3 major glaucoma trials in early manifest glaucoma trial patients
Ophthalmology
Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery
Ophthalmology
Interventions improve poor adherence with once daily glaucoma medications in electronically monitored patients
Ophthalmology
Three-year follow-up of the tube versus trabeculectomy study
Am J Ophthalmol
Angle-closure glaucoma in an urban population in southern India. The Andhra Pradesh Eye Disease Study
Ophthalmology
Epidemiology of angle-closure glaucoma. Prevalence, clinical types, and association with peripheral anterior chamber depth in the Egna-Neumarkt Glaucoma Study
Ophthalmology
Optical coherence tomography quantitative analysis of iris volume changes after pharmacologic mydriasis
Ophthalmology
Uveal effusion in primary angle-closure glaucoma
Ophthalmology
Follow-up of angle-closure glaucoma suspects
Am J Ophthalmol
Long-term outcomes in fellow eyes after acute primary angle closure in the contralateral eye
Ophthalmology
Plateau iris syndrome: changes in angle opening associated with dark, light, and pilocarpine administration
Am J Ophthalmol
The number of persons with glaucoma worldwide in 2010 and 2020
Br J Ophthalmol
The definition and classification of glaucoma in prevalence surveys
Br J Ophthalmol
Open-angle glaucoma—an epidemiologic overview
Ophthalmic Epidemiol
The myth of “21”
J Glaucoma
Possible mechanisms of primary angle-closure and malignant glaucoma
J Glaucoma
Comparison of optic nerve head topography and visual field in eyes with open angle and angle closure glaucoma
Ophthalmology
The visual field and nerve head in angle-closure glaucoma. A comparison of the effects of acute and chronic angle closure
Arch Ophthalmol
Genetics and biochemistry of primary congenital glaucoma
Ophthalmol Clin North Am
Optic disc morphology in open-angle glaucoma compared with anterior ischemic optic neuropathies
Invest Ophthalmol Vis Sci
The effect of experimental glaucoma and optic nerve transection on amacrine cells in the rat retina
Invest Ophthalmol Vis Sci
Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice
J Cell Biol
Regional differences in the structure of the lamina cribrosa and their relation to glaucomatous optic nerve damage
Arch Ophthalmol
Estimating the rate of progressive visual field damage among those with open-angle glaucoma from cross-sectional data
Invest Ophthalmol Vis Sci
Incidence of open-angle glaucoma: the Barbados Eye Studies. The Barbados Eye Studies Group
Arch Ophthalmol
Global data on visual impairment in 2002
Bull World Health Organ
Genetic risk of primary open-angle glaucoma. Population-based familial aggregation study
Arch Ophthalmol
Genetic factors in open-angle (simple and capsular) glaucoma. A population-based twin study
Acta Ophthalmol (Copenh)
Racial variations in the prevalence of primary open-angle glaucoma. The Baltimore Eye Survey
JAMA
Genetic etiologies of glaucoma
Arch Ophthalmol
Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma
Science
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