Elsevier

Human Pathology

Volume 5, Issue 2, March 1974, Pages 171-181
Human Pathology

Giant cell reparative granuloma outside the jaw bone: Diagnostic criteria and review of the literature with the first case described in the temporal bone

https://doi.org/10.1016/S0046-8177(74)80064-XGet rights and content

Abstract

A review of literature dealing with giant cell reparative granuloma of bone indicates that this lesion not only appears in the jaw bones but may also occur as a nonspecific reparative process in other skull bones. The etiology is intraosseous hemorrhage triggered by trauma or possibly inflammation (infection). The criteria for histologic diagnosis are reviewed, and the main points of differentiation from the giant cell tumor and other similar lesions are outlined. The condition is definitely a separate clinicopathologic entity. Literature is reviewed with special reference to giant cell tumors arising in the temporal bone, and evidence is brought forth showing that 18 of 23 previously reported cases actually represent giant cell reparative granulomas. Thus it appears that in the temporal bone the lesion is more common than the giant cell tumor. An additional case of giant cell reparative granuloma arising in the temporal bone is presented. The treatment of choice is surgical curettage, and the prognosis is good. Radiation therapy should be applied only to those lesions that are incompletely removed at surgery, that recur, or that cannot be approached adequately by surgical technique.

References (38)

  • HutterR.V.P. et al.

    Benign and malignant giant cell tumors of bone. A clinicopathological analysis of the natural history of the disease

    Cancer

    (1962)
  • JaffeH.L.
  • RayJ.W. et al.

    Giant cell lesions of the face and mouth

    Laryngoscope

    (1966)
  • WalkerD.G.

    Benign non-odontogenic tumors of jaws

    J. Oral Surg.

    (1970)
  • DahlinD.C. et al.

    Giant cell tumor: a study of 195 cases

    Cancer

    (1970)
  • GoldenbergR.R. et al.

    Giant cell tumor of bone. An analysis of 218 cases

    J. Bone Joint Surg.

    (1970)
  • PindborgJ.J.

    Tumors of the jaw (benign and malignant)

  • FriedbergS.A. et al.

    Giant cell lesions involving the nasal accessory sinuses

    Laryngoscope

    (1969)
  • DinningT.A.R.

    Osteoclastoma of the petrous temporal bone. Report of a case benefited by deep x-ray therapy

    Aust. New Zeal. J. Surg.

    (1953)
  • Cited by (115)

    • A new case of Giant Cell ‘Reparative’ Granuloma of the temporal bone related to trauma

      2017, Interdisciplinary Neurosurgery: Advanced Techniques and Case Management
      Citation Excerpt :

      Jaffe described Giant Cell Reparative Granuloma (GCRG) first in 1953 [1]. The first case of GCRG in the temporal bone was reported in 1974 by Hirschl and Katz [2]. Although GCRG is considered a benign lesion of bone, it is locally aggressive and requires surgical excision.

    • “Giant cell reparative tumor: An exceptional differential diagnosis for a lytic lesion of the temporal bone”

      2016, Neurochirurgie
      Citation Excerpt :

      According to Saw et al. [2], there appears to be numerous overlapping features of giant cell tumour (GCT) and GCRG arising in the skull bones. Hirschl and Katz [5] (Table 1) defined five major histological criteria in order to distinguish between the two lesions, but there are also borderline cases, which show features of both. Both lesions appear more frequently in females however most patients with GCRG are less than 35 years old at the time of diagnosis while 20–33% of patients with GCT are over 50 years of age [12].

    • Pediatric aggressive giant cell granuloma of nasal cavity

      2015, International Journal of Surgery Case Reports
      Citation Excerpt :

      Non-surgical treatments include supplementary modalities such as corticosteroid intralesional injection, calcitonin, interferon alpha, and radiation. These procedures should be considered as secondary tools for lesions that cannot be completely resected because of higher possibility of additional surgery [9]. We learned a significant lesson about diagnosis & treatment through very interesting experience in the aggressive change after the first surgery.

    • Proliferative, reparative, and reactive benign bone lesions that may be confused diagnostically with true osseous neoplasms

      2014, Seminars in Diagnostic Pathology
      Citation Excerpt :

      It is most often encountered in the mandible or, less commonly, the maxilla60–63 (Fig. 11). Cranial bones are only rarely affected.63,64 Multiple lesions in the mandible, particularly if they are symmetric and bilateral, may present the image of the heritable disease known as “cherubism.”65

    View all citing articles on Scopus
    *

    Assistant Professor, Department of Pathology and Experimental Pathology, New York Medical College. Associate Attending Pathologist, Flower and Fifth Avenue Hospitals, New York, New York.

    Assistant Professor, Department of Otolaryngology, New York Medical College. Assistant Attending Physician, Department of Surgery, Head and Neck Service, Memorial Hospital, New York, New York.

    View full text