ReviewsAmniotic fluid interleukin-6 and preterm delivery: a review☆
Section snippets
Data sources
For the main exposure (AF IL-6) and outcome (preterm labor or preterm delivery) of interest in this review article, we searched the English-language human literature in MEDLINE (1966 through September 1999), using the keywords “labor or infant,” “premature,” and “cytokines or interleukin-6,” and “amniotic fluid.” We also examined abstracts from the 19th Annual Meeting of the Society for Maternal-Fetal Medicine, San Francisco, California, 1999 and from the 32nd Annual Meeting of the Society for
Tabulation, integration, and results
Table 1 and Table 2 summarize results from studies that examined the association between AF IL-6 in intra-amniotic infection and preterm labor or preterm delivery and that we could fit into the paradigm presented.39, 41, 43, 46, 53, 54, 55, 56, 57, 58, 59, 60, 61 Other studies are referred to in the text when appropriate. Because of the importance of appropriate specimen collection and storage in laboratory studies of AF, we summarized this information in Table 1. Storage and collection are
Conclusion
We conclude that the literature has reached consensus that elevated AF IL-6 is consistently associated with intra-amniotic infection and preterm delivery. Future research should focus on clinical application of ELISA assays to detect AF IL-6 as it might indicate intra-amniotic infection. It should be noted that finding elevated AF IL-6 does not identify the specific organisms involved in intra-amniotic infection. Identification remains an important scientific as well as clinical goal.
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This work was supported by grant R40 MC 00113 from the Maternal and Child Health Bureau (Title V, Social Security Act), Health Resources and Services Administration, Department of Health and Human Services.