Biochemical and Biophysical Research Communications
Transcription initiation in the two leader exons of the rat IGF-I gene occurs from disperse versus localized sites
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Identification of the IGF-1 processing product human Ec/rodent Eb peptide in various tissues: Evidence for its differential regulation after exercise-induced muscle damage in humans
2017, Growth Hormone and IGF ResearchCitation Excerpt :IGF-1 gene is comprised of 6 exons in humans and rodents and spans a DNA region of approximately 80 kb [10]. Its regulation is complex and involves the usage of multiple promoters [11], different transcription initiation sites [12], alternative splicing and multiple polyadenylation sites [13–15]. Specifically, transcription initiation from either exon 1 or exon 2 generates transcripts referred as class I or II, respectively [16], while alternative splicing at the 3′-end gives rise to three mRNA transcripts in humans (IGF-1Ea, IGF-1Eb and IGF-1Ec) and two in rodents (IGF-1Ea and IGF-1Eb) [16,17].
Bovine and murine tissue expression of insulin like growth factor-I
2014, GeneCitation Excerpt :Based upon these technologies, distinct expression profiles exist for different species. For example, most tissues are believed to use Class 1 transcripts, although liver uses both with the Class 2 transcripts preferentially enhanced during development (Adamo et al., 1991a; Lin et al., 1998). Similarly, the isoform without exon 6, initially discovered in humans (human Eb), has been detected in mice, but only for Class 2 transcripts (Shavlakadze et al., 2005).
Class 2 IGF-1 isoforms are dispensable for viability, growth and maintenance of IGF-1 serum levels
2010, Growth Hormone and IGF ResearchPhenotypic improvement of dystrophic muscles by rAAV/microdystrophin vectors is augmented by Igf1 codelivery
2005, Molecular TherapyCitation Excerpt :Igf1-Eb is up-regulated in muscle subjected to stretch and therefore also referred to as mechano growth factor [31]. Both muscle-specific isoforms differ from the liver isoforms by using sequences encoded by exon 1 as a leader peptide in contrast to exon 2 [43]. The mouse muscle-specific Igf1 cDNA sequences have been submitted to GenBank.
Reconciling data from transgenic mice that overexpress IGF-I specifically in skeletal muscle
2005, Growth Hormone and IGF ResearchCloning and characterization of the bovine class 1 and class 2 insulin-like growth factor-I mRNAs
2003, Domestic Animal Endocrinology