Genetic susceptibility to pregnancy-related venous thromboembolism: Roles of factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations☆,☆☆,★,★★
Section snippets
Subjects
We performed a case-control study in 2 thrombosis centers at Hospital “Casa Sollievo della Sofferenza,” S. Giovanni Rotondo, and at A. Cardarelli Hospital, Naples. Between January 1995 and March 1998 we observed 42 women with a previous deep venous thrombosis during pregnancy or in the postpartum period. A group of 213 parous women without venous or arterial thromboses served as a control group. Both case patients and control subjects were white women living in Southern Italy. The 2 groups were
Results
As shown in Table I, all deep venous thromboses and pulmonary embolisms were observed in the postpartum period, except for 9 that occurred during pregnancy. Among these postpartum events, 9 (27.3%) occurred after a cesarean delivery. One patient carried antithrombin III deficiency and 1 carried protein S deficiency; in 2 other cases a primary antiphospholipid syndrome was present (Table I). No case patient had arterial or venous thrombosis outside the pregnancy or the postpartum period. Mean
Comment
It has previously been reported that pregnancy and the postpartum period are associated with greatly increased risk for venous thromboembolism among women with an inherited deficiency of a naturally occurring anticoagulant.4 The prevalences of pregnancy-related deep venous thrombosis and pulmonary embolism in a low-risk obstetric population were 0.71 and 0.15 per 1000 deliveries, respectively.21 Several studies have been published on the occurrence of thrombosis during pregnancy and in the
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High prevalence of factor V Leiden and prothrombin G20101A mutations in Kashmiri patients with venous thromboembolism
2018, GeneCitation Excerpt :The elevated total homocysteine levels have a toxic effect on vascular endothelium and clotting cascade and it has been associated with venous thrombosis in young adults and recurrent venous thrombosis in general, with about 10% frequency in patients with first episodes of venous thrombosis (Ueland and Refsum, 1989; McCully, 1969; Hankey and Eikelboom, 1999). There have been conflicting opinions about the role of MTHFR C677T polymorphism and risk of VTE among different populations (Arruda et al., 1997; Cattaneo et al., 1997; Ocal et al., 1997; Salden et al., 1997; Tosetto et al., 1997; Brown et al., 1998; Dilley et al., 1998; Grandone et al., 1998; Kluijtmans et al., 1998; Margaglione et al., 1998; Rintelen et al., 1999; Alhenc-Gelas et al., 1999; Cattaneo et al., 1999; Ho, 2000; Franco et al., 1999; Gemmati et al., 1999; Salomon et al., 1999; Lin et al., 2000; Akar et al., 2000; Angchaisuksiri et al., 2000; Couturaud et al., 2000; de Franchis et al., 2000; Fujimura et al., 2000; Gerhardt et al., 2000; Toydemir et al., 2000; Zheng et al., 2000; Guedon et al., 2001; Hanson et al., 2001; Hsu et al., 2001) Table 3. Kashmir, which is regarded worldwide as paradise on earth is also burdened with high incidence of venous thrombotic events.
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2015, Taiwanese Journal of Obstetrics and GynecologyGenetic variations in the annexin A5 gene and the risk of pregnancy-related venous thrombosis
2015, Journal of Thrombosis and HaemostasisPulmonary Complications of Hematologic Diseases
2015, Murray and Nadel's Textbook of Respiratory Medicine: Volume 1,2, Sixth EditionThromboembolism in pregnancy: Challenges and controversies in the prevention of pregnancy-associated venous thromboembolism and management of anticoagulation in women with mechanical prosthetic heart valves
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From Unità di Aterosclerosi e Trombosi, Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Divisione di Ematologia, Unità di Coagulazione, Ospedale A. Cardarelli, and Istituto di Medicina Interna e Geriatria, Università di Palermo.
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Supported by Telethon-Italy (grant E C 561).
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Reprint requests: Elvira Grandone, MD, Unità di Aterosclerosi e Trombosi, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini, S. Giovanni Rotondo (FG), 71013 Italy.
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0002-9378/98 $5.00 + 0 6/1/91595