Original paperExpression of CD44 isoforms in human skin cancer
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Cited by (27)
Hyaluronan-CD44 interaction with Rac1-dependent protein kinase N-γ promotes phospholipase Cγ1 activation, Ca<sup>2+</sup> signaling, and cortactin-cytoskeleton function leading to keratinocyte adhesion and differentiation
2004, Journal of Biological ChemistryCitation Excerpt :HA is a well known constituent of connective tissue extracellular matrices and, in particular, is abundant in stratified squamous epithelia including the epidermis of skin (1-3). HA is often anchored to CD44, a structurally/functionally important surface receptor that contains HA-binding site(s) (1-12). Transgenic mice expressing an antisense CD44 construct in their skin showed a significant reduction in endogenous HA on the keratinocyte cell surface and loss of keratinocyte functions (54).
CD44v6 in developing, dysplastic and malignant oral epithelia
2003, Oral OncologyCD44 is the principal mediator of hyaluronic-acid-induced melanoma cell proliferation
2001, Journal of Investigative DermatologyCitation Excerpt :The anti-panCD44 MoAb Hermes 3 was used in a 1:1000 dilution, the anti-IκB antibody was used 1:2000. Immunohistochemical stainings were performed as described previously (Simon et al. 1996) using punch biopsies from patients with primary tumors of MM (PMM; n = 6), cutaneous metastasis of MM (n = 5), or with benign melanocytic nevi (BMN; n = 7) at the time of surgery. Samples were snap-frozen and stored in liquid nitrogen until use.
Reduced level of CD44 and hyaluronan associated with unfavorable prognosis in clinical stage I cutaneous melanoma
2000, American Journal of PathologyCitation Excerpt :Other independent predictors of short RFS were tumor thickness (P = 0.001) and bleeding (P = 0.0346) (Table 4). The clinical role of CD44 and HA in primary cutaneous melanoma has remained obscure in previous clinical reports due to divergent results and relatively small materials that do not enable multivariate analysis.27–35 As far as we know, the current series consisting of patients with localized disease is decisively larger than any previous report on the CD44 level and prognosis of cutaneous melanoma.
Prognostic value of CD44 expression in invasive squamous cell carcinoma of the vulva
1999, Gynecologic OncologyActivation-dependent modulation of hyaluronate-receptor expression and of hyaluronate-avidity by human monocytes
1998, Journal of Investigative Dermatology