Fibrosis causes progressive kidney failure
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2021, Advances in Radiation OncologyCitation Excerpt :Radiation nephropathy is characterized by its development over an extended period, usually presenting months to years after radiation exposure. This latency is associated with slower cell turnover rates in renal tissues than in early responding tissues such as the gastrointestinal epithelium or bone marrow.23 Thompson et al24 reported that the frequency of renal dysfunction was higher after 5 years than within 5 years of RT, and a similar trend was observed in the current study.
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2003, Seminars in NephrologyEffect of pirfenidone against vanadate-induced kidney fibrosis in rats
2002, Biochemical PharmacologyCitation Excerpt :In addition, idiopathic glomerulosclerosis and renal interstitial fibrosis have been reported in children and adults [5,6]. Kidney fibrosis correlates well with the overall loss of renal function and could contribute to renal failure [7]. At the present time, fibrotic diseases of various organs in humans are treated chronically with high doses of corticosteriods and cytotoxic drugs that have serious systemic adverse effects [8,9].
Wistar rat as an animal model to study high-fat induced kidney damage: a systematic review
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