Protocol for the use of vitamin C in the treatment of cancer
References (38)
- et al.
The orthomolecular treatment of cancer. 1. The role of ascorbate in host resistance
Chem Biol Interact
(1974) - et al.
The orthomolecular treatment of cancer. II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer
Chem Biol Interact
(1974) - et al.
The orthomolecular treatment of cancer. III. Reticulum cell aarcoma: double complete regression induced by high-dose ascorbic acid therapy
Chem Biol Interact
(1975) - et al.
Innovation vs. quality control; an ‘unpublishable’ clinical trial of supplemental ascorbate in incurable cancer
Medical Hypotheses
(1991) - et al.
Leucocyte ascorbic acid and urinary hydroxyproline levels in patients bearing breast cancer with skeletal metastases
Eur J C Cancer
(1974) Vitamin C and infertility (letter)
Lancet
(1973)- et al.
Supplemental ascorbate in the supportive treatment of cancer: prolongation of survival times in terminal human cancer
- et al.
Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancer
- et al.
Prolongation of survival times in terminal human cancer by administration of supplemental ascorbate
J Int Acad Prev Med
(1979) - et al.
Prolongation of survival times of terminal cancer patients by administration of large doses of ascorbate
CBS Network News
Ascorbic acid and cancer: a review
Cancer Res
Enhanced lymphocyte blastogenesis by oral ascorbic acid
Ascorbic acid and immune functions: mechanisms of immunostimulation
Modulation of certain immunologic responses by vitamin C. III. Potentiation in vitro and in vivo lymphocyte responses
Int J Vitam Nutr Res
Vitamin C and the immune response
Experimentia
The multifactorial role of vitamin C in health and disease
Int J Vitam Nutr Res
Synergistic killing of Ehrlich ascites carcinoma cells by ascorbate and 3-amino-1, 2, 4-triazole
Oncology
Cited by (23)
Ascorbate kills breast cancer cells by rewiring metabolism via redox imbalance and energy crisis
2021, Free Radical Biology and MedicineCitation Excerpt :A later clinical trial conducted by the Mayo clinic rebutted the findings, triggering a heated debate on the issue [14]. Notably, the latter study used the oral route for ascorbate administration, while those of Cameron and Pauling resorted to intravenous injection [15]. Oral supplementation is subject to absorption limitations [16] and therefore yields a maximum plasma concentration of about 0.22 mM [17], while 100-time higher plasma concentrations could be safely achieved intravenously [16,18,19].
The Antioxidant Debate
2010, Explore: The Journal of Science and HealingCitation Excerpt :Vitamin C was postulated to have an important role in the treatment of cancer based upon the observations that vitamin C is involved in host resistance to cancer and that patients with cancer are often found to be depleted of vitamin C. Supplementation with vitamin C was suggested for its potential role to increase host resistance to cancer by stimulating immune function, increasing resistance to intercellular ground substance hydrolysis by hyaluronidase elaborated by tumor cells, stabilizing the production of hormones, and by protecting the pituitary-adrenal axis from the effects of stress.41,42 Case studies of terminal-stage cancer patients treated with a combination of high-dose oral and intravenous vitamin C who demonstrated prolonged survival were reported.41,43-45 Two subsequent double-blind randomized placebo-controlled trials showed no survival advantage with high-dose oral vitamin C supplementation as a treatment for cancer.21,24
Ascorbic acid interference in the measurement of serum biochemical parameters: In vivo and in vitro studies
2006, Clinical BiochemistryToxic and mutagenic effects of chromium(VI). A review
1996, PolyhedronMetabolism of Vitamin C in Health and Disease
1996, Advances in PharmacologyIntravenous ascorbate as a tumor cytotoxic chemotherapeutic agent
1995, Medical Hypotheses