Rodent bladder tumors do not always predict for humans
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Cited by (39)
Urinary Bladder, Ureter, and Urethra
2017, Boorman's Pathology of the Rat: Reference and AtlasEffects of co-administration of dietary sodium arsenate and 2,3-dimercaptopropane-1-sulfonic acid (DMPS) on the rat bladder epithelium
2012, ToxicologyCitation Excerpt :Most of the arsenic in the rats co-administered DMPS and AsV likely is excreted into bile as MAGD or complexed with DMPS. Urinary solids can be an important factor for urinary bladder tumorigenesis in rats but less so or not at all in humans (Cohen and Lawson, 1995; Cohen, 1998). In this study, some calcium phosphate-containing amorphous precipitate, MgNH4PO4 crystals and aggregates were detected in the urine of all groups of rats, with no differences between groups.
The Role of Cell Proliferation in the Etiology of Neoplasia
2010, Comprehensive Toxicology, Second EditionUnexpected tumour findings in lifetime rodent bioassay studies - What to do?
2002, Toxicology LettersCitation Excerpt :Adaptive changes resulting from chronic tissue irritation. An underlying reason can be crystallised test substance forming aggregates with proteins and lipids from body fluids in the excretory system; e.g. saccharine fed for lifetime to male rats results in urinary bladder carcinoma (Cohen and Lawson, 1995; Whysner and Williams, 1996a). Solid state carcinogenicity in rats at subcutaneous injection sites (Grasso et al., 1991) or in mice at implantation sites of microchips for animal identification (Tillmann et al., 1997) are other examples of the consequences of chronic tissue irritation in rodents, which are of little relevance in man.
Urinary tract calculi and thresholds in carcinogenesis
2002, Food and Chemical ToxicologyHazard characterisation of chemicals in food and diet: Dose response, mechanisms and extrapolation issues
2002, Food and Chemical Toxicology