Elsevier

Food and Chemical Toxicology

Volume 33, Issue 9, September 1995, Pages 771-784
Food and Chemical Toxicology

Effects of stones and other physical factors on the induction of rodent bladder cancer

https://doi.org/10.1016/0278-6915(95)00044-3Get rights and content

First page preview

First page preview
Click to open first page preview

References (143)

  • S. Fukushima et al.

    Promoting effects of various chemicals in rat urinary bladder carcinogenesis initiated by N-nitroson-butyl-(4-hydroxybutyl)amine

    Food and Chemical Toxicology

    (1983)
  • S. Fukushima et al.

    Promotion by ascorbic acid sodium erythorbate and ethoxyquin of neoplastic lesions in rats, initiated with N-butyl-N-(4-hydroxybutyl) nitrosamine

    Cancer Letters

    (1984)
  • E.M. Garland et al.

    The effects of dietary iron and folate supplementation on the physiological changes produced in weanling rats by sodium saccharin exposure

    Food and Chemical Toxicology

    (1993)
  • D.G. Goodman et al.

    Neoplastic and non-neoplastic lesions in aging F344 rats

    Toxicology and Applied Pharmacology

    (1979)
  • R. Hasegawa et al.

    The effect of different salts of saccharin on the rat urinary bladder

    Cancer Letters

    (1986)
  • R. Hasegawa et al.

    Bladder freeze ulceration and sodium saccharin feeding in the rat: examination for urinary nitrosamines, mutagens and bacteria, and effects on hepatic microsomal enzymes

    Food and Chemical Toxicology

    (1984)
  • H.D'A. Heck et al.

    The induction of bladder stones by terephthalic acid, dimethylterephthalate, and melamine (2,4,6-triamoin-S-triazine) and its relevance to risk assessment

    Regulatory Toxicology and Pharmacology

    (1985)
  • R.M. Hicks

    Hyperplasia and cornification of the transitional epithelium in the vitamin A-deficient rat

  • N. Ito et al.

    Studies of antioxidants: their carcinogenic and modifying effects on chemical carcinogenesis

    Food and Chemical Toxicology

    (1986)
  • C. King et al.

    Genotoxicity in the rodent urinary bladder

    Food and Chemical Toxicology

    (1995)
  • J.T. Lalich

    Experimentally induced uracil urolithiasis in rats

    Journal of Urology

    (1966)
  • G.R. Lankas et al.

    Induction of reversible urothelial cell hyperplasia in rats, by Clorsulon, a flukicide with weak carbonic anhydrase inhibitory activity

    Food and Chemical Toxicology

    (1992)
  • E. Lok et al.

    The inhibition of urease and proteases by sodium saccharin

    Cancer Letters

    (1982)
  • D.L. Arnold et al.

    Saccharin—a bitter sweet case

  • K. Babaya et al.

    Effect of rat urine fractionated by molecular weight on urinary bladder carcinogenesis

    Cancer Research

    (1982)
  • J.C. Barrett et al.

    Diethylstilbestrol induces malignant transformation without measurable gene mutation at two loci

    Science

    (1981)
  • S.W. Barthold

    Trichosomoides crassicauda infection, urinary bladder rat

  • G.M. Bonser et al.

    The potency of 20-methylcholanthrene relative to other carcinogens on bladder implantation

    British Journal of Cancer

    (1963)
  • G.A. Boorman et al.

    High incidence of spontaneous urinary bladder and ureter tumors in the Brown Norway rat

    Journal of the National Cancer Institute

    (1974)
  • G.T. Bryan

    Pellet implantation studies of carcinogenic compounds

    Journal of the National Cancer Institute

    (1969)
  • J.R. Bucher et al.

    Diuretic use and risk factors for cancer: results of animal studies

    Journal of the National Cancer Institute

    (1992)
  • W.H. Chapman et al.

    Effect of the urine and calculus formation on the incidence of bladder tumors in rats implanted with paraffin wax pellets

    Cancer Research

    (1973)
  • D.B. Clayson

    Bladder carcinogenesis in rats and mice: possibility of artifacts

  • D.B. Clayson et al.

    Acute response of the mouse bladder to derivatives of 4-ethylsulphonylnaphthalene-l-sulphonamide and bladder carcinogens measured by the uptake of [125I]-iodo-2-deoxyuridine

    Chemico-Biological Interactions

    (1973)
  • D.B. Clayson et al.

    The induction of tumours of the mouse bladder epithelium by 4-ethylsulphonylnaphthalene-1-sulphonamide

    British Journal of Cancer

    (1965)
  • D.B. Clayson et al.

    The influence of a foreign body on the induction of tumours of the bladder epithelium of the mouse

    British Journal of Cancer

    (1966)
  • S.M. Cohen

    Pathology of experimental bladder cancer in rodents

  • S.M. Cohen et al.

    A proposed role for silicates and protein in the proliferative effects of saccharin in the male rat urothelium

    Carcinogenesis

    (1991)
  • S.M. Cohen et al.

    Mitogenic effects of propoxur on male rat bladder urothelium

    Carcinogenesis

    (1995)
  • S.M. Cohen et al.

    Effect of sodium saccharin in the neonatal rad bladder

    Scanning Microscopy.

    (1995)
  • S.M. Cohen et al.

    Ultrastructural characteristics of the fetal and neonatal rat urinary bladder

    Scanning Microscopy

    (1988)
  • S.M. Cohen et al.

    Cell proliferation in carcinogenesis

    Science

    (1990)
  • S.M. Cohen et al.

    Genetic errors, cell proliferation and carcinogenesis

    Cancer Research

    (1991)
  • S.M. Cohen et al.

    Comparative bladder tumor promoting activity of sodium saccharin, sodium ascorbate, related acids and calcium salts in rats

    Cancer Research

    (1991)
  • S.M. Cohen et al.

    Comparative analysis of the proliferative response of the rat urinary bladder to sodium saccharin by light and scanning electron microscopy and autoradiography

    Scanning Microscopy

    (1990)
  • S.M. Cohen et al.

    Neoplasms of the urinary system

  • S.M. Cohen et al.

    Relationship between bladder changes produced in male rats by sodium saccharin treatment and formation of an insoluble, amorphous material in the urine

  • S.M. Cohen et al.

    Effect of regenerative hyperplasia on the urinary bladder: carcinogenesis of sodium saccharin and N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide

    Cancer Research

    (1982)
  • F. Deerberg et al.

    Spontaneous urinary bladder tumors in DA/Han rats: a feasible model of human bladder cancer

    Journal of the National Cancer Institute

    (1985)
  • J.M. Desesso et al.

    Relevance of Direct Bladder Exposure Studies to Human Health Concerns

    (1987)
  • Cited by (74)

    • Urinary Bladder, Ureter, and Urethra

      2017, Boorman's Pathology of the Rat: Reference and Atlas
    • Selection of appropriate tumour data sets for Benchmark Dose Modelling (BMD) and derivation of a Margin of Exposure (MoE) for substances that are genotoxic and carcinogenic: Considerations of biological relevance of tumour type, data quality and uncertainty assessment

      2014, Food and Chemical Toxicology
      Citation Excerpt :

      Chemically-induced bladder calculi or microcrystals in the rat or mouse bladder lumen lead to inflammation, hyperplasia and an increase in cellular proliferation and eventually to urothelial neoplasms. If doses of chemicals are administered below the amount necessary for calculus formation, no effects on the urothelium are produced (Clayson et al., 1995; Cohen, 1995, 1998). The rat, particularly the male rat, appears to be particularly susceptible to the formation of urinary precipitate (Cohen et al., 2000).

    • Lower Urinary Tract

      2013, Haschek and Rousseaux's Handbook of Toxicologic Pathology
    • Lower Urinary Tract

      2013, Haschek and Rousseaux's Handbook of Toxicologic Pathology, Third Edition: Volume 1-3
    View all citing articles on Scopus
    View full text