The production of cytokines by polymorphonuclear neutrophils

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Abstract

Cytokines orchestrate the complex network of cellullar interactions that regulate effector cell functions of natural and immune resistance. Although T cells, natural killer (NK) cells and monocytes/macrophages are the main producers of cytokines, a number of reports in the last few years have demonstrated that polymorphonuclear neutrophils (PMN) also have the ability to synthesize and release immunoregulatory cytokines. Here, Marco Cassatella describes novel facets of the regulation of cytokine production by PMN that highlight the involvement of the PMN in cell-cytokine crosstalk.

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    Marco A. Cassatella is at the Istituto di Patologia Generale, Università di Verona, Strada le Grazie 4, 37134 Verona, Italy.

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