A specific translocation, t(12;14)(q14–15; q23–24), characterizes a subgroup of uterine leiomyomas

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Abstract

We have cytogenetically investigated short-term cultures initiated from 34 uterine leiomyomas, all of which were histologically completely benign. Clonal chromosome abnormalities were detected in five cases, a normal female complement in 22, whereas, in the remaining seven tumors no karyotype could be established. Apparently identical reciprocal translocations, t(12;14)(q14–15;q23–24), were found as the sole abnormality in four tumors. The fifth abnormal case contained a t(2;14)(p11;p11). We conclude that chromosome aberrations may be found in myomas of the uterus, and that t(12;14)(q14–15;q23–24) characterizes a subset of these tumors.

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Supported by grants from the Swedish Cancer Society, the Swedish Work Environment Fund. the J A P Foundation for Medical Research, and the Assessorato Igiene e Sanità, Regione Autonoma Sardegna.

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