A specific translocation, t(12;14)(q14–15; q23–24), characterizes a subgroup of uterine leiomyomas☆
References (19)
- et al.
Structural chromosome aberrations in a case of angioleiomyoma
Cancer Genet Cytogenet
(1986) - et al.
Cytogenetic findings in a primary leiomyosarcoma of the prostate
Cancer Genet Cytogenet
(1986) - et al.
Reciprocal translocation t(3;12)(q27;q13) in lipoma
Cancer Genet Cyrogenet
(1986) - et al.
Cytogenetic studies of adipose tissue tumors. I. A benign lipoma with reciprocal translocation t(3;12)(q28;q14)
Cancer Genet Cytogenet
(1986) - et al.
Cytogenetic studies of adipose tissue tumors. II. Recurrent reciprocal translocation t(12;16)(q13;p11) in myxoid liposarcomas
Cancer Genet Cytogenet
(1986) - et al.
Clonal chromosome abnormalities in two liposarcomas
Cancer Genet Cytogenet
(1987) - et al.
Cancer Cytogenetics
(1987) Catalog of Chromosome Aberrations in Cancer
G-band analyses of a human intestinal leiomyosarcoma
Acta Pathol Microbiol Scand Sect A
(1976)
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2013, Reproductive BioMedicine OnlineCitation Excerpt :Chromosomal translocation is a defect caused by rearrangement of parts between nonhomologous chromosomes. The varieties of chromosomal rearrangements predict different genetic pathologies and allow classification of leiomyomata into subgroups (Dal Cin et al., 1995; Heim et al., 1988; Hu and Surti, 1991). About 40% of leiomyomata exhibit karyotypically detectable chromosomal abnormalities, frequently involving chromosome 12 (Nilbert et al., 1988; Rein et al., 1991).
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2010, Molecular and Cellular EndocrinologyIdentification and characterization of novel human transcripts embedded within HMGA2 in t(12;14)(q15;q24.1) uterine leiomyoma
2006, Mutation Research - Fundamental and Molecular Mechanisms of MutagenesisArray comparative genomic hybridization analysis of uterine leiomyosarcoma
2005, Gynecologic OncologyUpdates on the cytogenetics and molecular genetics of bone and soft tissue tumors: Leiomyoma
2005, Cancer Genetics and CytogeneticsCitation Excerpt :Although this may represent concomitant growth of normal cells, it is possible that these apparently normal cells may have undergone neoplastic transformation, and as has been suggested by some [10], with the chromosome changes appearing subsequent to this transformation. The most common chromosomal aberration in leiomyoma, seen in approximately 20% of karyotypically abnormal leiomyomas, is the characteristic translocation, t(12;14) (q15;q24) (Figs. 1 and 2), specifically associated with leiomyoma [23,34,35]. Other rearrangements involving 12q14∼q15, such as paracentric inversions, have also been observed [36–38].
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Supported by grants from the Swedish Cancer Society, the Swedish Work Environment Fund. the J A P Foundation for Medical Research, and the Assessorato Igiene e Sanità, Regione Autonoma Sardegna.