Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat

doi:10.1016/0047-6374(87)90057-1

Mechanisms of Ageing and Development

Volume 41, Issues 1–2, November 1987, Pages 125-137

https://doi.org/10.1016/0047-6374(87)90057-1 Get rights and content

Abstract

The free radical theory of aging was examined by measuring the formation of superoxide radical (SOR) and the level of lipid peroxides in various tissues of the aging rat. A significant increase in SOR production was seen in mitochondria prepared from the brain and the heart as rats aged. An elevation in the level of lipid peroxidation was also found in whole tissue homogenates of the brain and the liver. Vitamin E concentrations in the blood rose rapidly in young rats and remained steady except for a non significant drop in old animals. These results suggest that age-related degeneration of various tissues in the rat may be due to a rise in free radical production in the mitochondria.

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Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat

Abstract

Exp. Gerontol.

Mech. Ageing Dev.

Biochim. Biophys. Acta

Biochim. Biophys. Acta

Anal. Biochem.

Anal. Biochem.

Clin. Chim. Acta

Anal. Biochem.

Mech. Ageing Dev.

Mech. Ageing Dev.

Exp. Gerontol.

Exp. Gerontol.

Exp. Gerontol.

J. Clin. Pathol.

Aging: A theory based on free radical and radiation chemistry

J. Gerontol.

Prolongation of the normal life span by radiation protection chemicals

J. Gerontol.

Free radical theory of aging: Effect of the amount and degree of unsaturation of dietary fat on mortality rate

J. Gerontol.

Free radical involvement in the formation of lipopigments

The biology of free radicals

Science