Scientific paperA randomized trial of preoperative radiotherapy in cancer of the oropharynx and hypopharynx☆
References (9)
- et al.
Radical preoperative roentgen therapy in primarily inoperable advanced cancers of the head and neck
Radiology
(1959) - et al.
Effectiveness of small amounts of preoperative irradiation in preventing the growth of tumor cells disseminated at surgery
Cancer
(1961) - et al.
Preoperative radiation of head and neck cancer
Semin Oncol
(1977) The results of low dose preoperative irradiation for advanced carcinoma of the larynx
Frot Rad Ther Oncol
(1970)
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2010, Oral OncologyCitation Excerpt :Initially, pre-operative radiotherapy was preferred which was mainly based on the assumption that radiation would be more efficacious when tumour vascularisation was most optimal prior to surgery. However, this hypothesis could not be confirmed in a RCT in which patients with oropharyngeal and hypopharyngeal cancer with poor prognostic features were randomly assigned to receive surgery alone or pre-operative radiotherapy and surgery.11 It should be noted that the pre-operative regimen in this study consisted of 2000 rads only in five consecutive days, which is probably to low to expect a significant beneficial effect.
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Presented at the Joint Meeting of the American Society for Head and Neck Surgery and the Society of Head and Neck Surgeons, Toronto, Ontario, Canada, May 29–31, 1978.
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From The Departments of Otolaryngology and Radiology, Boston University School of Medicine, and Boston Veterans Administration Hospital, Boston, Massachusetts.