Abstract
Carotid ultrasonography is a safe and available noninvasive diagnostic tool that provides information about the carotid arteries’ characteristics and may be used for early detection of coronary artery disease as well as cardiovascular and stroke event risk stratifications. We performed a systematic search of articles discussing carotid ultrasonography in the English literature recorded in PubMed from 2010 to September 2012. Generally, the studies showed that internal carotid artery intima–media thickness is a more powerful variable than common carotid artery intima–media thickness. Moreover, the presence of carotid plaque and plaque volumes are more reliable and accurate estimators of coronary artery disease and risk of a stroke or cardiovascular event than intima–media thickness.
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Folsom AR, Kronmal RA, Detrano RC, et al. Coronary artery calcification compared with carotid intima-media thickness in the prediction of cardiovascular disease incidence: the Multi-Ethnic Study of Atherosclerosis (MESA). Arch Intern Med. 2008;168(12):1333–9.
Tzou WS, Douglas PS, Srinivasan SR, et al. Distribution and predictors of carotid intima-media thickness in young adults. Prev Cardiol. 2007;10(4):181–9.
Chambless LE, Heiss G, Folsom AR, et al. Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987-1993. Am J Epidemiol. 1997;146(6):483–94.
Naghavi M, Falk E, Hecht HS, et al. From vulnerable plaque to vulnerable patient — part III: executive summary of the Screening for Heart Attack Prevention and Education (SHAPE) Task Force report. Am J Cardiol. 2006;98:2H–15H.
Mackey RH, Greenland P, Goff Jr DC, Lloyd-Jones D, Sibley CT, Mora S. High-density lipoprotein cholesterol and particle concentrations, carotid atherosclerosis and coronary events: the Multi-Ethnic Study of Atherosclerosis. J Am Coll Cardiol. 2012;60(6):508–16.
Sillesen H, Muntendam P, Adourian A, Entrekin R, Garcia M, Falk E, et al. Carotid plaque burden as a measure of subclinical atherosclerosis; comparison with other tests for subclinical arterial disease in the High Risk Plaque BioImage Study. J Am Coll Cardiol Imaging. 2012;5(7):681–9.
Polak JF, Pencina MJ, Meisner A, Pencina KM, Brown LS, Wolf PA, et al. Associations of carotid Artery intima-media thickness (IMT) with risk factors and prevalent cardiovascular disease. J Ultrasound Med. 2010;29(12):1759–68.
D’Agostino Sr RB, Vasan RS, Pencina MJ, et al. General cardiovascular risk profile for use in primary care: the Framingham heart study. Circulation. 2008;117(6):743–53.
Conroy RM, Pyorala K, Fitzgerald AP, et al. Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project. Eur Heart J. 2003;24(11):987–1003.
Sirous D, Panteha R, Aamir ML, Hormoz RD, Matthew B. Importance of coronary artery calcium score in clinical practice. Clin Pract. 2012;9(5):555–64.
•• U.S. Preventive Services Task Force. Using nontraditional risk factors in coronary heart disease risk assessment: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2009;151(7):474–82. This article is important because it contains the consensus of experts about the role of carotid ultrasonography in clinical practice.
• Stein JH, Korcarz CE, Hurst RT, et al. Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force: endorsed by the Society for Vascular Medicine. J Am Soc Echocardiogr. 2008;21:93–111. This article is important because it defines the recommended level of expertise for carotid ultrasonography.
Lester SJ, Eleid MF, Khandheria BK, Hurst RT. Carotid intima-media thickness and coronary artery calcium score as indications of subclinical atherosclerosis. Mayo Clin Proc. 2009;84(3):229–33.
•• Yoichi I, Chenb JA, Bergmann SR. Carotid plaque, compared with carotid intima-media thickness, more accurately predicts coronary artery disease events: a meta-analysis. Atherosclerosis. 2012;220:128–33. This article is important because it contains a meta-analysis of 38 large studies.
O’Leary DH, Bots ML. Imaging of atherosclerosis: carotid intima–media rhickness. Eur Heart J. 2010;31:1682–9.
Elias-Smale SE, Maryam K, Verwoert GC, Koller MT, Steyerberg EW, Mattace-Raso FUS, et al. Common carotid intima-media thickness in cardiovascular risk stratification of older people: the Rotterdam Study. Eur J Prev Cardiol. 2011;19(4):698–705.
Polak JF, Pencina MJ, Pencina KM, O’Donnell CJ, Wolf PA, D’Agostino Sr RB. Carotid-wall intima–media thickness and cardiovascular events. N Engl J Med. 2011;365:213–21.
Inabaa Y, Chenb JA, Bergmann SR. Carotid plaque, compared with carotid intima-media thickness, more accurately predicts coronary artery disease events: a meta-analysis. Atherosclerosis. 2012;220:128–33.
Takasu J, Budoff MJ, Katz R, Rivera JJ, O’Brien KD, Shavelle DM, et al. Relationship between common carotid intima-media thickness and thoracic aortic calcification: the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis. 2010;209(1):142–6.
Budoff M. Atherosclerosis: should we use CIMT testing? New insights from Framingham. Nat Rev Cardiol. 2011;8(11):615–6.
Baker JV, Henry WK, Patel P, Bush TJ, Conley LJ, Mack WJ, et al. Study to understand the natural history of HIV/AIDS in the era of effective therapy investigators. Progression of carotid intima-media thickness in a contemporary human immunodeficiency virus cohort. Clin Infect Dis. 2011;53(8):826–35.
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Darabian, S., Hormuz, M., Latif, M.A. et al. The Role of Carotid Intimal Thickness Testing and Risk Prediction in the Development of Coronary Atherosclerosis. Curr Atheroscler Rep 15, 306 (2013). https://doi.org/10.1007/s11883-012-0306-4
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DOI: https://doi.org/10.1007/s11883-012-0306-4