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The Serial Changes of Ghrelin and Leptin Levels and Their Relations to Weight Loss After Laparoscopic Minigastric Bypass Surgery

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Abstract

Background

The ghrelin and leptin levels have been reported to be correlated with weight loss after bariatric surgery. However, the serial changes of ghrelin and leptin levels after laparoscopic minigastric bypass surgery (LMGBP) have not been reported yet. Therefore, we aimed to evaluate their serial changes and to analyze their relations to weight reduction after LMGBP.

Methods

Serial fasting serum leptin and ghrelin concentrations were measured in 68 morbidly obese patients before (M0) and 1 (M1), 3 (M3), 6 (M6), and 12 (M12) months after LMGBP surgery. The correlations between ghrelin, insulin, and leptin concentrations and weight reduction were analyzed.

Results

Leptin levels were significantly reduced at 1, 3, 6, and 12 months after surgery, respectively (vs M0, p < 0.001), whereas the ghrelin concentrations were not significantly changed after surgery. The percent of excess BMI lost (%EBL) 12 months after surgery was negatively correlated with higher preoperative ghrelin concentrations (p = 0.004) and larger preoperative BMI (p = 0.002) in the multivariate analysis.

Conclusion

Higher preoperative ghrelin concentrations and larger BMI are predictive of less %EBL at 12 months after LMGBP surgery.

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References

  1. Seidell JC. Obesity, insulin resistance and diabetes—a worldwide epidemic. Br J Nutr 2000;83 Suppl 1:S5–8.

    PubMed  CAS  Google Scholar 

  2. DeMaria EJ. Bariatric surgery for morbid obesity. N Engl J Med 2007;356:2176–83.

    Article  PubMed  CAS  Google Scholar 

  3. Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA 2004;292:1724–37.

    Article  PubMed  CAS  Google Scholar 

  4. Lee WJ, Wang W. Bariatric surgery: Asia-Pacific perspective. Obes Surg 2005;15:751–7.

    Article  PubMed  Google Scholar 

  5. Shah M, Simha V, Garg A. Review: long-term impact of bariatric surgery on body weight, comorbidities, and nutritional status. J Clin Endocrinol Metab 2006;91:4223–31.

    Article  PubMed  CAS  Google Scholar 

  6. Chau WY, Schmidt HJ, Kouli W, et al. Predictors of weight status following laparoscopic gastric bypass. Obes Surg 2006;16:1227–31.

    Article  Google Scholar 

  7. Perugini RA, Mason R, Czerniach DR, et al. Predictors of complication and suboptimal weight loss after laparoscopic Roux-en-Y gastric bypass: a series of 188 patients. Arch Surg 2003;138:541–5.

    Article  PubMed  Google Scholar 

  8. Chau WY, Schmidt HJ, Kouli W, et al. Patient characteristics impacting excess weight loss following laparoscopic adjustable gastric banding. Obes Surg 2005;15:346–50.

    Article  PubMed  Google Scholar 

  9. Lutfi R, Torquati A, Sekhar N, et al. Predictors of success after laparoscopic gastric bypass: a multivariate analysis of socioeconomic factors. Surg Endosc 2006;20:864–7.

    Article  PubMed  CAS  Google Scholar 

  10. Czupryniak L, Pawlowski M, Kumor A, et al. Predicting maximum Roux-en-Y gastric bypass-induced weight reduction–preoperative plasma leptin or body weight? Obes Surg 2007;17:162–7.

    Article  PubMed  Google Scholar 

  11. Klok MD, Jakobsdottir S, Drent ML. The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obes Rev 2007;8:21–34.

    Article  PubMed  CAS  Google Scholar 

  12. Kotidis EV, Koliakos GG, Baltzopoulos VG, et al. Serum ghrelin, leptin and adiponectin levels before and after weight loss: comparison of three methods of treatment—a prospective study. Obes Surg 2006;16:1425–32.

    Article  PubMed  Google Scholar 

  13. Ramos AP, de Abreu MR, Vendramini RC, et al. Decrease in circulating glucose, insulin and leptin levels and improvement in insulin resistance at 1 and 3 months after gastric bypass. Obes Surg 2006;16:1359–64.

    Article  PubMed  Google Scholar 

  14. Thong FS, Hudson R, Ross R, et al. Plasma leptin in moderately obese men: independent effects of weight loss and aerobic exercise. Am J Physiol Endocrinol Metab 2000;279:E307–13.

    PubMed  CAS  Google Scholar 

  15. Peeters TL. Ghrelin: a new player in the control of gastrointestinal functions. Gut 2005;54:1638–49.

    Article  PubMed  CAS  Google Scholar 

  16. Nijhuis J, van Dielen FM, Buurman WA, et al. Ghrelin, leptin and insulin levels after restrictive surgery: a 2-year follow-up study. Obes Surg 2004;14:783–7.

    Article  PubMed  Google Scholar 

  17. Stoeckli R, Chanda R, Langer I, et al. Changes of body weight and plasma ghrelin levels after gastric banding and gastric bypass. Obes Res 2004;12:346–50.

    Article  PubMed  CAS  Google Scholar 

  18. Christou NV, Look D, McLean AP. Pre- and post-prandial plasma ghrelin levels do not correlate with satiety or failure to achieve a successful outcome after Roux-en-Y gastric bypass. Obes Surg 2005;15:1017–23.

    Article  PubMed  Google Scholar 

  19. Busetto L, Segato G, De Luca M, et al. High ghrelin concentration is not a predictor of less weight loss in morbidly obese women treated with laparoscopic adjustable gastric banding. Obes Surg 2006;16:1068–74.

    Article  PubMed  Google Scholar 

  20. Lee WJ, Yu PJ, Wang W, et al. Laparoscopic Roux-en-Y versus mini-gastric bypass for the treatment of morbid obesity: a prospective randomized controlled clinical trial. Ann Surg 2005;242:20–8.

    Article  PubMed  Google Scholar 

  21. Deitel M, Greenstein RJ. Recommendations for reporting weight loss. Obes Surg 2003;13:159–60.

    Article  PubMed  Google Scholar 

  22. Deitel M, Gawdat K, Melissas J. Reporting weight loss 2007. Obes Surg 2007;17:565–8.

    Article  PubMed  Google Scholar 

  23. Ram E, Vishne T, Maayan R, et al. The relationship between BMI, plasma leptin, insulin and proinsulin before and after laparoscopic adjustable gastric banding. Obes Surg 2005;15:1456–62.

    Article  PubMed  Google Scholar 

  24. Borg CM, le Roux CW, Ghatei MA, et al. Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety. Br J Surg 2006;93:210–5.

    Article  PubMed  CAS  Google Scholar 

  25. Korner J, Bessler M, Cirilo LJ, et al. Effects of Roux-en-Y gastric bypass surgery on fasting and postprandial concentrations of plasma ghrelin, peptide YY, and insulin. J Clin Endocrinol Metab 2005;90:359–65.

    Article  PubMed  CAS  Google Scholar 

  26. Christou NV, Look D, McLean AP. Pre- and post-prandial plasma ghrelin levels do not correlate with satiety or failure to achieve a successful outcome after Roux-en-Y gastric bypass. Obes Surg 2005;15:1017–23.

    Article  PubMed  Google Scholar 

  27. Couce ME, Cottam D, Esplen J, et al. Is ghrelin the culprit for weight loss after gastric bypass surgery? A negative answer. Obes Surg 2006;16:870–8.

    Article  PubMed  Google Scholar 

  28. Alvarado R, Alami RS, Hsu G, et al. The impact of preoperative weight loss in patients undergoing laparoscopic Roux-en-Y gastric bypass. Obes Surg 2005;15:1282–6.

    Article  PubMed  CAS  Google Scholar 

  29. Gasteyger C, Suter M, Calmes JM, et al. Changes in body composition, metabolic profile and nutritional status 24 months after gastric banding. Obes Surg 2006;16:243–50.

    Article  PubMed  CAS  Google Scholar 

  30. Carrasco F, Papapietro K, Csendes A, et al. Changes in resting energy expenditure and body composition after weight loss following Roux-en-Y gastric bypass. Obes Surg 2007;17:608–16.

    Article  PubMed  Google Scholar 

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Acknowledgement

The present study was funded by the National Science Council of Taiwan (grant number: NSC95-2314-B002-093). All the authors do not have conflict of interest in this work.

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Authors and Affiliations

  1. Department of Internal Medicine, College of Medicine, National Taiwan University, National Taiwan University Hospital, No. 7, Chung-Shan S. Road, Taipei, Taiwan

    Jyh-Ming Liou, Jaw-Town Lin, Hsiu-Po Wang, Yi-Chia Lee, Han-Mo Chiu & Ming-Shiang Wu

  2. Department of Primary Care Medicine, National Taiwan University Hospital, Taipei, Taiwan

    Jaw-Town Lin & Ming-Shiang Wu

  3. Department of Surgery, Min-Sheng General Hospital, Tao-Yuan, Taiwan

    Wei-Jei Lee

Authors
  1. Jyh-Ming Liou
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  2. Jaw-Town Lin
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  3. Wei-Jei Lee
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  4. Hsiu-Po Wang
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  5. Yi-Chia Lee
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  7. Ming-Shiang Wu
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Correspondence to Ming-Shiang Wu.

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Liou, JM., Lin, JT., Lee, WJ. et al. The Serial Changes of Ghrelin and Leptin Levels and Their Relations to Weight Loss After Laparoscopic Minigastric Bypass Surgery. OBES SURG 18, 84–89 (2008). https://doi.org/10.1007/s11695-007-9305-x

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  • DOI: https://doi.org/10.1007/s11695-007-9305-x

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