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Should breast conservation be offered to young women with breast cancer?

  • Invited Commentary
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The Original Article was published on 12 August 2010

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References

  1. Blichert-Toft M, Nielsen M, During M, Moller S, Rank F, Overgaard M, Mouridsen HT (2008) Long-term results of breast conserving surgery vs. mastectomy for early stage invasive breast cancer: 20-year follow-up of the Danish randomized DBCG-82TM protocol. Acta Oncol 47(4):672–681

    Article  PubMed  Google Scholar 

  2. Clark RM, Whelan T, Levine M, Roberts R, Willan A, McCulloch P, Lipa M, Wilkinson RH, Mahoney LJ (1996) Randomized clinical trial of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer: an update. Ontario Clinical Oncology Group. J Natl Cancer Inst 88(22):1659–1664

    Article  PubMed  CAS  Google Scholar 

  3. Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER, Jeong JH, Wolmark N (2002) Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 347(16):1233–1241

    Article  PubMed  Google Scholar 

  4. Jacobson JA, Danforth DN, Cowan KH, Angelo T, Steinberg SM, Pierce L, Lippman ME, Lichter AS, Glatstein E, Okunieff P (1995) Ten-year results of a comparison of conservation with mastectomy in the treatment of stage I and II breast cancer. N Engl J Med 332(14):907–911

    Article  PubMed  CAS  Google Scholar 

  5. Lichter AS, Lippman ME, Danforth DN Jr, d’Angelo T, Steinberg SM, de Moss E, MacDonald HD, Reichert CM, Merino M, Swain SM et al (1992) Mastectomy versus breast-conserving therapy in the treatment of stage I and II carcinoma of the breast: a randomized trial at the National Cancer Institute. J Clin Oncol 10(6):976–983

    PubMed  CAS  Google Scholar 

  6. Poggi MM, Danforth DN, Sciuto LC, Smith SL, Steinberg SM, Liewehr DJ, Menard C, Lippman ME, Lichter AS, Altemus RM (2003) Eighteen-year results in the treatment of early breast carcinoma with mastectomy versus breast conservation therapy: the National Cancer Institute Randomized Trial. Cancer 98(4):697–702

    Article  PubMed  Google Scholar 

  7. Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, Aguilar M, Marubini E (2002) Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 347(16):1227–1232

    Article  PubMed  Google Scholar 

  8. Coulombe G, Tyldesley S, Speers C, Paltiel C, Aquino-Parsons C, Bernstein V, Truong PT, Keyes M, Olivotto IA (2007) Is mastectomy superior to breast-conserving treatment for young women? Int J Radiat Oncol Biol Phys 67(5):1282–1290

    Article  PubMed  Google Scholar 

  9. Kim SH, Simkovich-Heerdt A, Tran KN, Maclean B, Borgen PI (1998) Women 35 years of age or younger have higher locoregional relapse rates after undergoing breast conservation therapy. J Am Coll Surg 187(1):1–8

    Article  PubMed  CAS  Google Scholar 

  10. Kurtz JM, Amalric R, Brandone H, Ayme Y, Spitalier JM (1989) Local recurrence after breast-conserving surgery and radiotherapy. Helv Chir Acta 55(6):837–842

    PubMed  CAS  Google Scholar 

  11. Kurtz JM, Jacquemier J, Amalric R, Brandone H, Ayme Y, Hans D, Bressac C, Spitalier JM (1990) Why are local recurrences after breast-conserving therapy more frequent in younger patients? J Clin Oncol 8(4):591–598

    PubMed  CAS  Google Scholar 

  12. Kurtz JM, Spitalier JM, Amalric R, Brandone H, Ayme Y, Bressac C, Hans D (1988) Mammary recurrences in women younger than forty. Int J Radiat Oncol Biol Phys 15(2):271–276

    Article  PubMed  CAS  Google Scholar 

  13. Nixon AJ, Neuberg D, Hayes DF, Gelman R, Connolly JL, Schnitt S, Abner A, Recht A, Vicini F, Harris JR (1994) Relationship of patient age to pathologic features of the tumor and prognosis for patients with stage I or II breast cancer. J Clin Oncol 12(5):888–894

    PubMed  CAS  Google Scholar 

  14. Oh JL, Bonnen M, Outlaw ED, Schechter NR, Perkins GH, Strom EA, Babiera G, Oswald MJ, Allen PK, Thames HD et al (2006) The impact of young age on locoregional recurrence after doxorubicin-based breast conservation therapy in patients 40 years old or younger: how young is “young”? Int J Radiat Oncol Biol Phys 65(5):1345–1352

    Article  PubMed  Google Scholar 

  15. Recht A, Connolly JL, Schnitt SJ, Silver B, Rose MA, Love S, Harris JR (1988) The effect of young age on tumor recurrence in the treated breast after conservative surgery and radiotherapy. Int J Radiat Oncol Biol Phys 14(1):3–10

    Article  PubMed  CAS  Google Scholar 

  16. Beadle BM, Woodward WA, Tucker SL, Outlaw ED, Allen PK, Oh JL, Strom EA, Perkins GH, Tereffe W, Yu TK et al (2009) Ten-year recurrence rates in young women with breast cancer by locoregional treatment approach. Int J Radiat Oncol Biol Phys 73(3):734–744

    Article  PubMed  Google Scholar 

  17. Greenbaum MP, Strom EA, Allen PK, Perkins GH, Oh JL, Tereffe W, Yu TK, Buchholz TA, Woodward WA (2010) Low locoregional recurrence rates in patients treated after 2000 with doxorubicin based chemotherapy, modified radical mastectomy, and post-mastectomy radiation. Radiother Oncol 95(3):312–316

    Article  PubMed  CAS  Google Scholar 

  18. Vaidya JS, Joseph DJ, Tobias JS, Bulsara M, Wenz F, Saunders C, Alvarado M, Flyger HL, Massarut S, Eiermann W et al (2010) Targeted intraoperative radiotherapy versus whole breast radiotherapy for breast cancer (TARGIT-A trial): an international, prospective, randomised, non-inferiority phase 3 trial. Lancet 376(9735):91–102

    Article  PubMed  Google Scholar 

  19. Clarke M, Collins R, Darby S, Davies C, Elphinstone P, Evans E, Godwin J, Gray R, Hicks C, James S et al (2005) Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 366(9503):2087–2106

    PubMed  CAS  Google Scholar 

  20. Karlsson P, Cole BF, Price KN, Coates AS, Castiglione-Gertsch M, Gusterson BA, Murray E, Lindtner J, Collins JP, Holmberg SB et al (2007) The role of the number of uninvolved lymph nodes in predicting locoregional recurrence in breast cancer. J Clin Oncol 25(15):2019–2026

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Radiation Oncology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA

    Wendy A. Woodward & Thomas A. Buchholz

Authors
  1. Wendy A. Woodward
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  2. Thomas A. Buchholz
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Corresponding author

Correspondence to Thomas A. Buchholz.

Additional information

This is an invited commentary to article doi: 10.1007/s10549-010-1110-x.

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Woodward, W.A., Buchholz, T.A. Should breast conservation be offered to young women with breast cancer?. Breast Cancer Res Treat 127, 217–219 (2011). https://doi.org/10.1007/s10549-010-1205-4

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  • DOI: https://doi.org/10.1007/s10549-010-1205-4

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