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The hOGG1 Ser326Cys polymorphism and breast cancer risk: a meta-analysis

  • Epidemiology
  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

Abstract

It was reported that the functional polymorphism Ser326Cys in the human 8-oxoguanine DNA glycosylase gene was associated with breast cancer risk; however, the published studies have inconsistent conclusions. To elucidate the effect of hOGG1 Ser326Cys on the susceptibility to breast cancer, all available studies were collected in this meta-analysis. We extracted the data from 10 case–control studies that were published in the PubMed database from 2003 to 2008 using the search phrases “human 8-oxoguanine DNA glycosylase, hOGG1, OGG1, OGG, polymorphism, genetic variation, and breast cancer.” This meta-analysis included 4,963 breast cancer cases and 4,776 control subjects. The results showed that individuals who carrying the hOGG1 326Cys allele in the additive model did not have significantly increased risk of breast cancer compared with those carrying the 326Ser allele (P = 0.47, OR = 1.02; 95% CI = 0.96–1.09); similarly, no significant association between the hOGG1 326Cys allele and breast cancer risk was found either in the recessive genetic model (P = 0.34, OR = 1.06; 95% CI = 0.94–1.18) for Cys/Cys versus Ser/Cys + Ser/Ser, or dominant genetic model (P = 0.78, OR = 1.01; 95% CI = 0.93–1.11) for Cys/Cys + Ser/Cys versus Ser/Ser. In the stratified analysis, the meta-analysis showed the association between hOGG1 326Cys allele in the additive model and breast cancer was significant in European subjects (P = 0.04, OR = 0.71; 95% CI = 0.51–0.98), and dominant genetic model (P = 0.004, OR = 0.44; 95% CI = 0.25–0.77). However, the association was not significant between this polymorphism and different menopausal status (premenopausal and postmenopausal) and the other ethnicities (Asians and Americans). The meta-analysis suggested that the hOGG1 326Cys allele plays a significant protective effect to breast cancer in European women.

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Acknowledgments

All authors read and approved the final article. We are grateful to the members of the Institute of Cancer Prevention and Treatment of Harbin Medical University for supporting our study.

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Authors and Affiliations

  1. Institute of Cancer Prevention and Treatment, Harbin Medical University, Baojian Road 6, Nangang District, 150081, Harbin, China

    Weiguang Yuan, Yue Yang, Wangyang Chen, Jingwei Wang, Da Pang & Dianjun Li

  2. Department of Immunology, Harbin Medical University, 150081, Harbin, China

    Weiguang Yuan & Dianjun Li

  3. Laboratory of Medical Genetics, Harbin Medical University, 150081, Harbin, China

    Lidan Xu

  4. Department of Medical Oncology, The Third Affiliated Hospital of Harbin Medical University, 150081, Harbin, China

    Yuanxi Feng

  5. Department of Surgery, The Third Affiliated Hospital of Harbin Medical University, 150081, Harbin, China

    Da Pang

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  1. Weiguang Yuan
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  2. Lidan Xu
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  4. Yue Yang
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  7. Da Pang
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Correspondence to Da Pang or Dianjun Li.

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Weiguang Yuan and Lidan Xu contributed equally to this work.

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Yuan, W., Xu, L., Feng, Y. et al. The hOGG1 Ser326Cys polymorphism and breast cancer risk: a meta-analysis. Breast Cancer Res Treat 122, 835–842 (2010). https://doi.org/10.1007/s10549-009-0722-5

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  • DOI: https://doi.org/10.1007/s10549-009-0722-5

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