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Recovery from deepening of the upper eyelid sulcus after switching from bimatoprost to latanoprost

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

Although useful for reducing intraocular pressure (IOP), bimatoprost (BIM) can cause deepening of the upper eyelid sulcus (DUES), one of the symptoms of prostaglandin-associated periorbitopathy (PAP). We investigated recovery from BIM-induced DUES after switching treatment to latanoprost (LAT).

Design

Prospective, observer-masked, open-label study.

Methods

Twenty-five Japanese patients suffering from primary open-angle glaucoma treated with LAT in both eyes for longer than 6 months and requiring further IOP reduction were prospectively enrolled in the study. During the first 6 months after the switch to BIM, 15 of the 25 patients (60 %) developed DUES. Among these patients, 13 were switched back to LAT and re-examined for DUES at 2-month intervals for an additional 6 months.

Results

Two months after the switch back to LAT, for 11 of the 13 patients (85 %) the DUES symptoms had either decreased or disappeared, and this was maintained for at least 6 months. During this time, 6 of 8 patients (75 %) subjectively positive for DUES self-reported a decrease in DUES.

Conclusions

Although DUES is a frequent side effect of treatment with BIM, switching to LAT may reverse the condition for most patients.

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Authors and Affiliations

  1. Department of Ophthalmology, Tokyo Metropolitan Geriatric Hospital, 35-2 Sakaecho, Itabashi, Tokyo, 173-0015, Japan

    Rei Sakata

  2. Yotsuya Shirato Eye Clinic, Tokyo, Japan

    Shiroaki Shirato

  3. Miyata Eye Hospital, Miyazaki, Japan

    Kazunori Miyata

  4. Department of Ophthalmology, University of Tokyo, Tokyo, Japan

    Makoto Aihara

Authors
  1. Rei Sakata
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  2. Shiroaki Shirato
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  3. Kazunori Miyata
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  4. Makoto Aihara
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Corresponding author

Correspondence to Rei Sakata.

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Sakata, R., Shirato, S., Miyata, K. et al. Recovery from deepening of the upper eyelid sulcus after switching from bimatoprost to latanoprost. Jpn J Ophthalmol 57, 179–184 (2013). https://doi.org/10.1007/s10384-012-0219-3

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  • DOI: https://doi.org/10.1007/s10384-012-0219-3

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