Abstract
Purpose
To describe the results of intralesional injection of the sclerosing agent sodium tetradecyl sulfate in patients with orbital lymphangioma.
Methods
Four young patients with a history of orbital lymphangioma were treated on one or more occasions with percutaneous puncture and injection of sodium tetradecyl sulfate under computed tomography guidance. Resolution of the signs and symptoms, complications resulting from surgery, and recurrence of bleeding were studied.
Results
Three patients with a long-standing history of unilateral proptosis and one patient with progressive unilateral visual loss from multiple recurrent orbital hemorrhages were studied. Treatment ranged from one to three sodium tetradecyl sulfate injections. All patients showed improvement of their signs and symptoms after treatment. A decrease in the size of lesions was demonstrated by orbital imaging. Visual acuity and intraocular pressure remained unchanged. Complications included transient postoperative localized inflammation in all cases and transient ophthalmoparesis in one patient. Follow-up time ranged between 15 and 36 months, during which no recurrence of bleeding was observed.
Conclusions
Our study suggests that intralesional injection of sodium tetradecyl sulfate under computed tomography guidance is an effective treatment for patients with orbital lymphangioma and is not associated with vision-threatening complications.
Similar content being viewed by others
References
Harris GJ, Sakol PJ, Bonavolonta G, De Conciliis C. An analysis of thirty cases of orbital lymphangioma: pathophysiologic considerations and management recommendations. Ophthalmology 1990;97:1583–1592.
Jone IS. Lymphangiomas of the ocular adnexa: an analysis of sixty-two cases. Am J Ophthalmol 1961;51:481–509.
Kennerdell JS, Maroon JC, Garrity JA, Abla AA. Surgical management of orbital lymphangioma with the carbon dioxide laser. Am J Ophthalmol 1986;102:308–314.
Behrendt S, Bersmeier H, Randzio G. Fractionated beta-irradiation of a conjunctival lymphangioma. Ophthalmologica 1991;203:161–163.
Sires BS, Goins CR, Anderson RL, Holds JB. Systemic corticosteroid use in orbital lymphangioma. Ophthalmic Plast Reconstr Surg 2001;17:85–90.
Suzuki Y, Obana A, Gohto Y, Miki T, Otuka H, Inoue Y. Management of orbital lymphangioma using intralesional injection of OK-432. Br J Ophthalmol 2000;84:614–617.
Wojno TH. Sotradecol (sodium tetradecyl sulfate) injection of orbital lymphangioma. Ophthal Plast Reconstr Surg 1999;15:432–437.
Svendsen PA, Wikholm G, Rodriguez M, et al. Direct puncture and sclerotherapy with Sotradecol. Intervent Neuroradiol 2001;7:193–199.
Schwarcz RM, Ben Simon GJ, Cook T, Goldberg RA. Sclerosing therapy as first line treatment for low flow vascular lesions of the orbit. Am J Ophthalmol 2006;141:333–339.
Goldman MP. Sodium tetradecyl sulfate for sclerotherapy treatment of veins: is compounding pharmacy solution safe? Dermatol Surg 2004;30:1454–1456.
Hren C, Garcia C, Clark RE. Sclerotherapy of telangiectases using sodium tetradecyl sulfate (Sotradecol). N C Med J 1996;57:42–46.
Berenguer B, Burrows P, Zurakowski D, Mulliken JB. Sclerotherapy of craniofacial venous malformations: complications and results. Plast Reconstr Surg 1999;104:1–11.
Malhotra AD, Parikh M, Garibaldi DC, Merbs SL, Miller NR, Murphy K. Resection of an orbital lymphangioma with the aid of an intralesional liquid polymer. Am J Neuroradiol 2005;26:2630–2634.
Hsuan J, Malhotra R, Davis G, Selva D. Orbital decompression for gross proptosis associated with orbital lymphangioma. Ophthal Plast Reconstr Surg 2004;20:463–465.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Poonyathalang, A., Preechawat, P., Jiarakongmun, P. et al. Sclerosing therapy for orbital lymphangioma using sodium tetradecyl sulfate. Jpn J Ophthalmol 52, 298–304 (2008). https://doi.org/10.1007/s10384-008-0547-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10384-008-0547-5