Original articleCaffeine-potentiated chemotherapy for metastatic osteosarcoma
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2020, European Journal of PharmacologyCitation Excerpt :Methylxanthines have been widely used for therapeutic purposes for decades, with proven therapeutic benefits in different medical scopes. For example, the naturally occurring methylxanthines like caffeine, theophylline, and theobromine have been used in the treatment of respiratory diseases (Lam and Newhouse, 1990), cardiovascular diseases, cancer (Hayashi et al., 2005; Kimura et al., 2009) and the commercially produced xanthine derivative drug like pentoxifylline has been widely documented to have immunomodulatory properties including the downregulation of Tumour Necrosis Factor (TNF) α to treat the injurious effects due to immune activation in the syndrome of chronic heart failure (CHF) (Shaw et al., 2009). Pentoxifylline and its active metabolites enhance blood flow by decreasing blood viscosity and ameliorating erythrocyte flexibility.
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2018, Journal of Food and Drug AnalysisCitation Excerpt :Zerumbone blocked the pancreatic cancer PaCa cells-associated angiogenesis through the inhibition of NF-κB and NF-κB-dependent proangiogenic gene products [143]. Caffeine-potentiated chemotheraphy consisting of 1.5 g caffeine/m2/day has been demonstrated to potentially prevent local recurrence or metastasis in patients with metastatic lung adenocarcinoma and prolong the survival rate of osteosarcoma patients with pulmonary metastasis [144,145]. Moreover, caffeine-potentiated chemotheraphy (1.5 g caffeine/m2/day) applied to five patients with clear cell sarcorma also decreased the risk for metastasis (distant metastasis newly developed in only one patient) [146].
Evaluation of anticancer effects and enhanced doxorubicin cytotoxicity of xanthine derivatives using canine hemangiosarcoma cell lines
2013, Research in Veterinary ScienceCitation Excerpt :Therefore, caffeine has two anticancer effects and the ability to enhance anticancer drugs by inhibiting DNA repair pathways (Valenzuela et al., 2000). Several reports have indicated that caffeine has been utilized with chemotherapy for bone and soft tissue sarcoma (Hayashi et al., 2005; Kimura et al., 2009; Takeuchi et al., 2007). High doses of caffeine (1.5 g/m2) have been administered in caffeine-assisted chemotherapy (Karita et al., 2011; Tsuchiya et al., 1998, 1999) and induced a complete response in more than 80% of the observed patients (Tsuchiya et al., 1999) and enhanced the 5-year survival rate to approximately 90% (Tsuchiya et al., 1998).
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