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Genetic analysis of a malignant meningioma and associated metastases

  • Case Report - Brain Tumors
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Abstract

To identify genes altered in a highly aggressive metastatic meningioma primary as well as its metastases. Exome sequencing of a primary anaplastic meningioma and metastatic lesions in which DNA could be extracted and compared to germline DNA. Genetic analysis of the metastatic sites found 31 common mutations among the primary tumor and two metastatic sites. Additionally, genetic mutations were identified which were either infrequently (MUC3A, ALDH1A3, HOXA1) or not at all previously described in meningiomas (CASS4, CMKLR1). Exome sequencing of a metastatic meningioma and its distant metastases outside the CNS identified mutations that were not previously well described.

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Acknowledgements

The CCSG: P30CA016058 for contribution of OSUCCC—Genomics Shared Resource/Bioinformatics Shared Resource.

We offer our deepest gratitude to the family of our patient for supporting our efforts to improve care of patients with metastatic meningiomas by allowing us to investigate their loved one’s disease and ensuring the accuracy of our report.

Funding

This study was funded by CTSA Grant number (UL1TR002733).

Author information

Authors and Affiliations

  1. Department of Neurological Surgery, The Ohio State University Wexner Medical Center, Ohio State University, Columbus, OH, USA

    Kristin Huntoon & J. Bradley Elder

  2. Department of Neurological Surgery, MD Anderson Cancer Center, Houston, TX, USA

    Kristin Huntoon

  3. Department of Biomedical Informatics, The Ohio State University Wexner Medical Center, Ohio State University, Columbus, OH, USA

    Ayse Selen Yilmaz & Maciej Pietrzak

  4. Division of Hematology, Department of Internal Medicine, College of Medicine, OSUCCC Genomics Shared Resource, Columbus, OH, USA

    Xi Chen & Pearlly Yan

  5. Department of Cancer Biology & Genetics, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA

    Amanda Ewart Toland

Authors
  1. Kristin Huntoon
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  2. Ayse Selen Yilmaz
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  3. Maciej Pietrzak
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  4. Xi Chen
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  5. Pearlly Yan
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  6. Amanda Ewart Toland
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  7. J. Bradley Elder
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Corresponding author

Correspondence to Kristin Huntoon.

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This article does not contain any studies with human participants or animals performed by any of the authors. Informed consent was obtained from the family to present this case report.

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Huntoon, K., Yilmaz, A.S., Pietrzak, M. et al. Genetic analysis of a malignant meningioma and associated metastases. Acta Neurochir 164, 1401–1405 (2022). https://doi.org/10.1007/s00701-021-05101-w

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  • DOI: https://doi.org/10.1007/s00701-021-05101-w

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