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A large-scale meta-analysis of the association between the ANKK1/DRD2 Taq1A polymorphism and alcohol dependence

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Abstract

Alcohol dependence (AD) is a common neuropsychiatric disorder with high heritability. A number of studies have analyzed the association between the Taq1A polymorphism (located in the gene cluster ANKK1/DRD2) and AD. In the present study, we conducted a large-scale meta-analysis to confirm the association between the Taq1A polymorphism and the risk for AD in over 18,000 subjects included in 61 case–control studies that were published up to August 2012. Our meta-analysis demonstrated both allelic and genotypic association between the Taq1A polymorphism and AD susceptibility [allelic: P(Z) = 1.1 × 10−5, OR = 1.19; genotypic: P(Z) = 3.2 × 10−5, OR = 1.24]. The association remained significant after adjustment for publication bias using the trim and fill method. Sensitivity analysis showed that the effect size of the Taq1A polymorphism on AD risk was moderate and not influenced by any individual study. The pooled odds ratio from published studies decreased with the year of publication, but stabilized after the year 2001. Subgroup analysis indicated that publication bias could be influenced by racial ancestry. In summary, this large-scale meta-analysis confirmed the association between the Taq1A polymorphism and AD. Future studies are required to investigate the functional significance of the ANKK1/DRD2 Taq1A polymorphism in AD.

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Acknowledgments

This study was supported by the National Institute of Health (NIH) Grants K99/R00 DA022891 and the grant from the Alcoholic Beverage Medical Research Foundation (ABMRF).

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The authors have no conflict of interest to report.

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Authors and Affiliations

  1. Department of Psychiatry, Yale University School of Medicine, VA Medical Center/116A2, 950 Campbell Avenue, West Haven, CT, 06516, USA

    Fan Wang, Arthur Simen, Albert Arias & Huiping Zhang

  2. VA Connecticut Healthcare System, West Haven, CT, USA

    Fan Wang, Albert Arias & Huiping Zhang

  3. Merck Research Laboratories, North Wales, PA, USA

    Arthur Simen

  4. College of Life Science and Technology, Center for Human Genome Research, Huazhong University of Science and Technology, Wuhan, China

    Qun-Wei Lu

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  1. Fan Wang
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Correspondence to Huiping Zhang.

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Wang, F., Simen, A., Arias, A. et al. A large-scale meta-analysis of the association between the ANKK1/DRD2 Taq1A polymorphism and alcohol dependence. Hum Genet 132, 347–358 (2013). https://doi.org/10.1007/s00439-012-1251-6

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  • DOI: https://doi.org/10.1007/s00439-012-1251-6

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