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Vascular endothelial growth factor in colorectal cancer

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International Journal of Colorectal Disease Aims and scope Submit manuscript

Abstract

Background

Angiogenesis plays an important role in colorectal cancer progression. Evidence from preclinical and clinical studies indicates that vascular endothelial growth factor (VEGF) is the predominant angiogenic factor in human colorectal cancer and is associated with formation of metastases and poor prognosis. Based on these results it was hypothesized that attacking one or more of the VEGF-mediated mechanisms may be promising in the treatment of colorectal cancer.

Aims

This article reviews the role of VEGF in colon cancer and summarizes recent advances in the treatment of colorectal cancer by anti-VEGF strategies.

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Authors and Affiliations

  1. Department of Surgery, University Clinic Grosshadern, Ludwig-Maximilians-University, Marchioninistrasse 15, 81377, Munich, Germany

    Markus Guba, Hendrik Seeliger, Axel Kleespies, Karl-Walter Jauch & Christiane Bruns

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  1. Markus Guba
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  2. Hendrik Seeliger
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  3. Axel Kleespies
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  4. Karl-Walter Jauch
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  5. Christiane Bruns
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Correspondence to Markus Guba.

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M. Guba and H. Seeliger contributed equally to this paper

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Guba, M., Seeliger, H., Kleespies, A. et al. Vascular endothelial growth factor in colorectal cancer. Int J Colorectal Dis 19, 510–517 (2004). https://doi.org/10.1007/s00384-003-0576-y

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