Abstract
Alveolar macrophages have been investigated for years by approaches involving macrophage extraction from the lung by bronchoalveolar lavage, or by cell removal from lung tissue. Since extracted macrophages are studied outside their natural milieu, there is little understanding of the extent to which alveolar macrophages interact with the epithelium, or with one another to generate the lung’s innate immune response to pathogen challenge. Here, we review new evidence of macrophage-epithelial interactions in the lung, and we address the emerging understanding that the alveolar epithelium plays an important role in orchestrating the macrophage-driven immune response.
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Acknowledgments
We are grateful to Drs. Sunita Bhattacharya, Chris Schindler, and M. Naeem Islam for their help with comments and manuscript preparation. JB was supported by NIH grants HL36024, HL57556, and HL122730.
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Bhattacharya, J., Westphalen, K. Macrophage-epithelial interactions in pulmonary alveoli. Semin Immunopathol 38, 461–469 (2016). https://doi.org/10.1007/s00281-016-0569-x
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DOI: https://doi.org/10.1007/s00281-016-0569-x