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Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-κB and p38 MAPK in HMC-1 human mast cell line

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Abstract.

Objective and design:

Mast cell-mediated allergic inflammation is involved in many diseases such as asthma, sinusitis, and rheumatoid arthritis. Mast cells induce production of pro-inflammatory cytokines with immune regulatory properties. We investigated the effect of quercetin on the expression of pro-inflammatory cytokines in human mast cell line, HMC-1.

Methods:

HMC-1 cells were stimulated with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187 (PMACI).

Results:

Quercetin decreased the gene expression and production of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-8 in PMACI-stimulated HMC-1 cells. Quercetin attenuated PMACI-induced activation of NF-κB and p38 mitogen-activated protein kinase.

Conclusion:

Our study provides evidence that quercetin may suitable for the treatment of mast cell-derived allergic inflammatory diseases.

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Authors and Affiliations

  1. Department of Surgery, Chosun University Medical School, Gwangju, 501-759, Republic of Korea

    Y.-D. Min

  2. Department of Pharmacology, Chosun University Medical School, Gwangju, 501-759, Republic of Korea

    C.-H. Choi & H. Bark

  3. Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 700-422, Republic of Korea

    H.-Y. Son, H.-H. Park, S. Lee & S.-H. Kim

  4. Department of Periodontology, Kyungpook National University, Daegu, 700-422, Republic of Korea

    J.-W. Park

  5. Department of Pathology and Regenerative Medicine, School of Dentistry, Kyungpook National University, Daegu, 700-422, Republic of Korea

    E.-K. Park & H.-I. Shin

Authors
  1. Y.-D. Min
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  2. C.-H. Choi
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  3. H. Bark
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  4. H.-Y. Son
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  5. H.-H. Park
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  6. S. Lee
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  7. J.-W. Park
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  8. E.-K. Park
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  9. H.-I. Shin
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  10. S.-H. Kim
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Corresponding author

Correspondence to S.-H. Kim.

Additional information

Received 18 October 2006; returned for revision 26 November 2006; accepted by A. Falus 4 December 2006

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Min, YD., Choi, CH., Bark, H. et al. Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-κB and p38 MAPK in HMC-1 human mast cell line. Inflamm. res. 56, 210–215 (2007). https://doi.org/10.1007/s00011-007-6172-9

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  • DOI: https://doi.org/10.1007/s00011-007-6172-9

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