Skip to main content
Log in

Primary osteosarcoma of the breast

  • Case Report
  • Published:
Breast Cancer Aims and scope Submit manuscript

Abstract

We report a case of primary osteosarcoma of the breast, which is a rare histological type of all breast tumors. A 58-year-old woman had noticed a right breast mass long before presenting to our hospital because it had gradually increased in size. The mass was bony-hard, 90 x 70 mm in size, and was located mainly in the upper outer quadrant of the left breast. Mammography demonstrated a round radiopaque mass with a shaggy outline. There were small bone metastases to the pelvis and scapula on bone radionuclide scan, but no other metastasis was observed with subsequent investigations. Modified radical mastectomy including axillary lymph node dissection was performed. Histologically, the excised tumor was consistent with extraskeletal osteosarcoma of the breast accompanied by lymph node metastses. In spite of adjuvant chemotherapy, the patient suffered a local recurrence four months later and died of aggressive multiple metastases 7 months after surgery.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Silver SA, Tavassoli FA: Primary osteogenic sarcoma of the breast: a clinicopathologic analysis of 50 cases.Am J Surg Pathol 22:925–933, 1998.

    Article  PubMed  CAS  Google Scholar 

  2. The Japanese breast cancer society: General rules for clinical and pathlogical recording of breast cancer. The 14 th edition Sept, 2000 (in Japanese).

  3. Kennedy T, Biggart JD: Sarcoma of the breast.Br J Cancer 21:635–644, 1967.

    PubMed  CAS  Google Scholar 

  4. Oberman HA: Sarcomas of the breast.Cancer 18:1233- 1243, 1965.

    Article  PubMed  CAS  Google Scholar 

  5. Vorobiof G, Hariparsad G, Freinkel W, Said H, Vorobiof DA: Primary osteosarcoma of the breast: a case report.Breast J 9:231–233, 2003.

    Article  PubMed  Google Scholar 

  6. Ciatto S, Bonardi R, Cataliotti L, Cardona G: Sarcomas of the breast: a multicenter series of 70 cases.Neoplasma 39:375–379, 1992.

    PubMed  CAS  Google Scholar 

  7. Jernstorm P, Lindberg AL, Meland ON: Osteogenic sarcoma of the mammary gland.Am J Clin Path 40:521–526, 1963.

    Google Scholar 

  8. Aubrey DA, Andrews GS: Mammary osteogenic sarcoma.Br J Surg 58:472–474, 1971.

    Article  PubMed  CAS  Google Scholar 

  9. Berg JW, De Crosse JJ, Fracchia AA, Farrow J: Stromal sarcomas of the breast - a unified approach to connective tissue sarcoma other than cytosarcomas phylloides.Cancer 15:418, 1962.

    Article  PubMed  CAS  Google Scholar 

  10. Muller AG, Van Zyl JA: Primary osteosarcoma of the breast.J Surg Oncol 52:135–136, 1993.

    Article  PubMed  CAS  Google Scholar 

  11. Brown AL, Holwill SD, Thomas VA, Sacks NP, GivenWilson R: Case report: Primary osteosarcoma of the breast: imaging and histological features.Clin Radiol 53:920–922, 1998.

    Article  PubMed  CAS  Google Scholar 

  12. Norris HJ, Taylor HB: Sarcomas and related mesenchymal tumors of the breast.Cancer 22:22–28, 1968.

    Article  PubMed  CAS  Google Scholar 

  13. Barnes L, Pietruszka M: Sarcomas of the breast: a clinicopathologic analysis of ten cases.Cancer 40:1577- 1585, 1977.

    Article  PubMed  CAS  Google Scholar 

  14. Lumsden AB, Harrison D, Cherry U, Going JJ, Muir B: Osteogenic sarcoma -a rare primary tumour of the breast.Eur J Surg Oncol 11:183–186, 1985.

    PubMed  CAS  Google Scholar 

  15. Chung EB, Enzinger FM: Extraskeletal osteosarcoma.Cancer 60:1132–1142, 1987.

    Article  PubMed  CAS  Google Scholar 

  16. Brunat-Mentigny M, Demaille MC, Quitana E, Olive D, Bachelot C, Boitetot A, Gentet JC, Noir P, Roche H, Thyss JP, Vannier JP, Kalifa C: [The reproduction in France of Rosen’s protocol for osteosarcom.Bull Cancer 75:201–206, 1988.

    PubMed  CAS  Google Scholar 

  17. Rodier-Bruant C, Jaeck D, Dufour P, Oberling F, Renaud R: [Breast osteosarcoma. Review of the literature and presentation of two cases].Rev Fr Gynecol Obstet 86:43–48, 1991.

    PubMed  CAS  Google Scholar 

  18. Eilber FR, Rosen G: Adjuvant chemotherapy for osteosarcoma.Semin Oncol 16:312–322, 1989.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hirohito Momoi.

About this article

Cite this article

Momoi, H., Wada, Y., Sarumaru, S. et al. Primary osteosarcoma of the breast. Breast Cancer 11, 396–400 (2004). https://doi.org/10.1007/BF02968048

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02968048

Key words

Navigation