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Serum levels of some acute phase proteins in kidney and urinary tract urothelial cancers

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Abstract

Early diagnosis of kidney and urothelial cancer requires some new sensitive and specific methods. In this study the diagnostic use of serum α1-acid glycoprotein (α1-AG), coeruloplasmin, α1-antitrypsin (α1-AT), α2-macroglobulin (α2-MG) and albumin in patients with kidney, urinary bladder and upper tract urothelial cancer was evaluated. In kidney cancer patients the serum levels of α1-AG, coeruloplasmin and α1-AT were significantly increased over the controls (p<0.001), however, albumin was decreased (p<0.005). Sensitivity was relatively high for α1-AG (85%), albumin (85%) and α1-AT (77%). In patients with urinary tract urothelial cancer α1-AG, α1-AT and coeruloplasmin were also increased but not as much as in kidney cancer. Sensitivity of α1-AT (63%), albumin (75%) and α1-AT (66%) was also lower than in kidney cancer. This study has established the relative importance of α1-AT and albumin determination in patients with kidney as well as with urothelial cancer.

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Pejovic, M., Djordjevic, V., Ignjatovic, I. et al. Serum levels of some acute phase proteins in kidney and urinary tract urothelial cancers. International Urology and Nephrology 29, 427–432 (1997). https://doi.org/10.1007/BF02551108

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  • DOI: https://doi.org/10.1007/BF02551108

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