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von Recklinghausen’s disease and malignant changes in three patients

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Abstract

Three Japanese patients with von Recklinghausen’s disease and malignant changes were studied. The primary lesions of malignant changes were the chest wall in Case 1, the buttock in Case 2, and the neck in Case 3. After excision of the tumors, there were local recurrences in Cases 1 and 2. Distant metastases developed during treatment in these patients. One of the patients (Case 1) died 21 months after the initial diagnosis of malignancy. Multidisciplinary treatment was of some value in suppressing local recurrences and pulmonary metastases in Case 2. Pulmonary metastases were evident at the time of admission to our hospital in Case 3. Although the primary and metastatic tumors were removed, the patient died 8 months after the initial diagnosis of malignancy. We conclude that careful follow-up should be required in patients with von Recklinghausen’s disease because of the possibility of malignant changes. When there is a suspicion of malignancy, an extended en-block excision must be performed.

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References

  1. Goldman, R.L., Jones, S.E. and Heusinkveld. R.S.: Combination chemotherapy of metastatic malignant schwannoma with vincristine, adriamycin, cyclophosphamide, and imidazole carboxamide. A case report. Cancer 39: 1955–1977.

  2. Brasfield, R.D. and Das Gupta, T.K.: Von Recklinghausen’s disease: A clinicopathological study. Ann. Surg. 175: 86–104, 1972.

    Article  PubMed  CAS  Google Scholar 

  3. Preston, W.F., Walsh, W.S. and Clarke, T.H.: Cutaneous neurofibromatosis. Arch. Surg. 64: 813–827, 1952.

    CAS  Google Scholar 

  4. Hosoi, K.: Multiple neurofibromatosis. Arch. Surg. 22: 265–281, 1931.

    Google Scholar 

  5. Knight, W.A., Murphy, W.K. and Gottlieb, J.A.: Neurofibromatosis associated with malignant neurofibromas. Arch. Dermatol. 107: 747–750, 1973.

    Article  PubMed  Google Scholar 

  6. Niimura, M.: Malignant tumors associated with von Recklinghausen’s disease. Hifuka no Rinsho 14: 365–379, 1972. (in Japanese)

    Google Scholar 

  7. Wander, J. V. and Das Gupta, T.K.: Neurofibromatosis. Current Probl. Surg. 14: 36–45, 1977.

    Google Scholar 

  8. Ackerman, L.V. and Rosai, J.: Surgical Pathology, fifth ed. pp. 1131–1132, Mosby St Louis, 1974.

  9. Ghosh, B.C., Ghosh, L., Huvos, A.G. and Fortner, J.G.: Malignant schwannoma. A clinicopathological study. Cancer 31: 184–190, 1973.

    Article  PubMed  CAS  Google Scholar 

  10. Morton, D.L., Eilber, F.R., Townsend, C.M. Jr., Grant, T.T., Mirra, J. and Weisenburger, T.H.: Limb salvage from a multidisciplinary treatment approach for skeletal and soft tissue sarcomas of the extremity. Ann. Surg. 184: 268–278, 1976.

    PubMed  CAS  Google Scholar 

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Kodama, K., Sakurai, T., Okada, N. et al. von Recklinghausen’s disease and malignant changes in three patients. The Japanese Journal of Surgery 12, 362–367 (1982). https://doi.org/10.1007/BF02469636

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