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Free radical theory of aging: The “free radical” diseases

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Abstract

The free radical theory of aging postulates that free radical reactions are responsible for the progressive accumulation of changes with time associated with or responsible for the ever-increasing likelihood of disease and death that accompanies advancing age.

Modulation of the normal distribution of deleterious free radical reaction-induced changes throughout the body by genetic and environmental differences between individuals results in patterns of change, in some sufficiently different from the normal aging pattern to be recognized as disease. These “free radical” diseases can be classified into three groups in which a given disorder is mainly due to: 1) genetics, 2) a combination of genetic and environmental factors, and 3) largely to environmental influences.

The growing number of “free radical” diseases includes the two major causes of death, cancer and atherosclerosis. To illustrate the role of free radicals in disease a discussion is presented, of cancer, atherosclerosis, essential hypertension, senile dementia of the Alzheimer’s type, amyloidosis, and the immune deficiency of age.

Dietary intervention in the “free radical” diseases can reasonably be expected to decrease the period of senescence and to increase by 5 or more years the span of healthy productive life.

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Authors and Affiliations

  1. Department of Medicine, University of Nebraska College of Medicine, 42nd & Dewey Avenue, Omaha, Nebraska, 68105

    Denham Harman M.D., Ph.D.

  2. Department of Biochemistry, University of Nebraska College of Medicine, 42nd & Dewey Avenue, Omaha, Nebraska, 68105

    Denham Harman M.D., Ph.D.

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  1. Denham Harman M.D., Ph.D.
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Harman, D. Free radical theory of aging: The “free radical” diseases. AGE 7, 111–131 (1984). https://doi.org/10.1007/BF02431866

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