Abstract
In vivo administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to rats produced significant alterations in Na-K, Ca, Mg ATPase and protein kinase activity, and receptor binding activity to insulin, concanavalin A, glucagon and epidermal growth factor in the canaliculi-rich plasma membrane fraction of the hepatocytes. Some of the changes are dose-related, and generally follow the time course of the sign of TCDD poisoning in the rat (e.g., the loss in body weight). Such TCDD-induced changes in membrane proteins and subsequent alteration in membrane functions appear to be extensive.
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Matsumura, F., Brewster, D.W., Madhukar, B.V. et al. Alteration of rat hepatic plasma membrane functions by 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD). Arch. Environ. Contam. Toxicol. 13, 509–515 (1984). https://doi.org/10.1007/BF01056330
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DOI: https://doi.org/10.1007/BF01056330