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Collagenase — A marker enzyme in human bladder cancer?

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Summary

Collagenase activity in human bladder carcinomas was measured against 14C-labeled collagen as substrate. Enzyme activity in vivo increased with the degree of penetration of the bladder wall. It was not detectable or low in the cases of superficially infiltrating tumours (A, B1, B2) and high in the cases of deeply infiltrating tumours (C, D). These results suggest that collagenase activity of advanced tumours is predominantly expressed in the perivesical layer of the bladder wall. A quantitative estimate of this enzyme may thus help to distinguish between Stage B and Stage C tumours.

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Authors and Affiliations

  1. Institute of Molecular-Biology of the Austrian Academy of Sciences, Salzburg, Austria

    G. Wirl & J. Frick

  2. Department of Urology of the General Hospital, Salzburg, Austria

    G. Wirl & J. Frick

  3. Abteilung Biologie, Institut für Molekularbiologie der Österreichischen Akademie der Wissenschaften, Billrothstraße 11, A-5020, Salzburg, Austria

    G. Wirl

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  1. G. Wirl
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Wirl, G., Frick, J. Collagenase — A marker enzyme in human bladder cancer?. Urol. Res. 7, 103–108 (1979). https://doi.org/10.1007/BF00254689

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  • DOI: https://doi.org/10.1007/BF00254689

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