Skip to main content

Anxiety Disorders and Medical Comorbidity: Treatment Implications

  • Chapter
  • First Online:
Anxiety Disorders

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1191))

Abstract

Anxiety disorders are debilitating psychological disorders characterized by a wide range of cognitive and somatic symptoms. Anxiety sufferers have a higher lifetime prevalence of various medical problems. Chronic medical conditions furthermore increase the likelihood of psychiatric disorders and overall dysfunction. Lifetime rates of cardiovascular, respiratory, gastrointestinal, and other medical problems are disproportionately high in anxiety and panic/fear sufferers. The heightened comorbidity is not surprising as many symptoms of anxiety and panic/fear mimic symptoms of medical conditions. Panic disorder specifically is strongly linked to medical conditions due to its salient somatic symptoms, such as dyspnea, dizziness, numbness, chest pain, and heart palpitations, all of which can signal danger and deterioration for chronic disease sufferers. This chapter identifies shared correlates of medical illness and anxiety disorders and evidence for misinterpretation of symptoms as medically relevant and offers an analysis of implications for treatment of both types of conditions. We will concentrate on medical conditions with high associations for anxiety and panic by aspects of symptomatology, specifically neurological disorders (fibromyalgia, epilepsy, cerebral palsy), diabetes, gastrointestinal illness (irritable bowel syndrome, gastroesophageal reflux disease), and cardiovascular and respiratory illnesses (asthma).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Martínez-Poles J, Nedkova-Hristova V, Escribano-Paredes JB, García-Madrona S, Natera-Villalba E, Estévez-Fraga C, et al. Incobotulinumtoxin A for sialorrhea in neurological disorders: a real-life experience. Toxins (Basel). 2018 June;10(6):217.

    Article  PubMed Central  CAS  Google Scholar 

  2. Montesó-Curto P, García-Martinez M, Romaguera S, Mateu ML, Cubí-Guillén MT, Sarrió-Colas L, et al. Problems and solutions for patients with fibromyalgia: building new helping relationships. J Adv Nurs. 2018 Feb;74(2):339–49.

    Article  PubMed  Google Scholar 

  3. Arnold L, Goldenberg D, Stanford S, Lalonde J, Sandhu H, Keck P, et al. Gabapentin in the treatment of fibromyalgia: a randomized, double-blind, placebo-controlled, multicenter trial. Arthritis Rheum. 2007 Apr;56(4):1336–44.

    Article  CAS  PubMed  Google Scholar 

  4. Córdoba-Torrecilla S, Aparicio VA, Soriano-Maldonado A, Estévez-López F, Segura-Jiménez V, Álvarez-Gallardo I, et al. Physical fitness is associated with anxiety levels in women with fibromyalgia: the al-Ándalus project. Qual Life Res. 2016 Apr;25(4):1053–8.

    Article  PubMed  Google Scholar 

  5. Lami MJ, Martínez MP, Miró E, Sánchez AI, Guzmán MA. Catastrophizing, acceptance, and coping as mediators between pain and emotional distress and disability in fibromyalgia. J Clin Psychol Med Settings. 2018 Mar;25(1):80–92.

    Article  PubMed  Google Scholar 

  6. Luciano J, Guallar J, Aguado J, López-del-Hoyo Y, Olivan B, Magallón R, et al. Effectiveness of group acceptance and commitment therapy for fibromyalgia: a 6-month randomized controlled trial (EFFIGACT study). Pain. 2014 Apr;155(4):693–702.

    Article  PubMed  Google Scholar 

  7. Falcão D, Sales L, Leite J, Feldman D, Valim V, Natour J. Cognitive behavioral therapy for the treatment of fibromyalgia syndrome: a randomized controlled trial. J Musculoskelet Pain. 2008 Jan;16(3):133–40.

    Article  Google Scholar 

  8. Carleton R, Richter A, Asmundson G. Attention modification in persons with fibromyalgia: a double blind, randomized clinical trial. Cogn Behav Ther. 2011 Dec;40(4):279–90.

    Article  PubMed  Google Scholar 

  9. Duschek S, Werner N, Limbert N, Winkelmann A, Montoya P. Attentional bias toward negative information in patients with fibromyalgia syndrome. Pain Med. 2014 Apr;15(4):603–12.

    Article  PubMed  Google Scholar 

  10. Bernardy K, Klose P, Welsch P, Häuser W. Efficacy, acceptability and safety of cognitive behavioural therapies in fibromyalgia syndrome – a systematic review and meta-analysis of randomized controlled trials. Eur J Pain. 2017 Feb;22(2):242–60.

    Article  PubMed  Google Scholar 

  11. Vallejo M, Ortega J, Rivera J, Comeche M, Vallejo-Slocker L. Internet versus face-to-face group cognitive-behavioral therapy for fibromyalgia: a randomized control trial. J Psychiatr Res. 2015 Sep;68:106–13.

    Article  PubMed  Google Scholar 

  12. García J, Simón MA, Durán M, Canceller J, Aneiros FJ. Differential efficacy of a cognitive-behavioral intervention versus pharmacological treatment in the management of fibromyalgic syndrome. Psychol Health Med. 2006 Nov;11(4):498–506.

    Article  PubMed  Google Scholar 

  13. Martínez MP, Miró E, Sánchez AI, Díaz-Piedra C, Cáliz R, Vlaeyen JW, et al. Cognitive-behavioral therapy for insomnia and sleep hygiene in fibromyalgia: a randomized controlled trial. J Behav Med. 2014 Aug;37(4):683–97.

    Article  PubMed  Google Scholar 

  14. Lami M, Martínez M, Miró E, Sánchez A, Prados G, Cáliz R, et al. Efficacy of combined cognitive-behavioral therapy for insomnia and pain in patients with fibromyalgia: a randomized controlled trial. Cognit Ther Res. 2018 Feb;42(1):63–79.

    Article  Google Scholar 

  15. Grossman P, Niemann L, Schmidt S, Walach H. Mindfulness-based stress reduction and health benefits: a meta-analysis. J Psychosom Res. 2004 Jul;57(1):35–43.

    Article  PubMed  Google Scholar 

  16. Veehof M, Oskam M-J, Schreurs K, Bohlmeijer E. Acceptance-based interventions for the treatment of chronic pain: a systematic review and meta-analysis. Pain. 2011 Mar;152(3):533–42.

    Article  PubMed  Google Scholar 

  17. Wicksell RK, Kemani M, Jensen K, Kosek E, Kadetoff D, Sorjonen K, et al. Acceptance and commitment therapy for fibromyalgia: a randomized controlled trial. Eur J Pain. 2013 Apr;17(4):599–611.

    Article  CAS  PubMed  Google Scholar 

  18. Zech N, Hansen E, Bernardy K, Häuser W. Efficacy, acceptability and safety of guided imagery/hypnosis in fibromyalgia – a systematic review and meta-analysis of randomized controlled trials. Eur J Pain. 2017 Feb;21(2):217–27.

    Article  CAS  PubMed  Google Scholar 

  19. Montero-Marín J, Navarro-Gil M, Puebla-Guedea M, Luciano JV, Van Gordon W, Shonin E, et al. Efficacy of “attachment-based compassion therapy” in the treatment of fibromyalgia: a randomized controlled trial. Front Psychiatry. 2018 Jan;8(307)

    Google Scholar 

  20. Vago DR, Nakamura Y. Selective attentional bias towards pain-related threat in fibromyalgia: preliminary evidence for effects of mindfulness meditation training. Cognit Ther Res. 2011 Dec;35(6):581–94.

    Article  Google Scholar 

  21. Mur E, Drexler A, Gruber J, Hartig F, Gunther V. Electromyography biofeedback therapy in fibromyalgia. Wien Med Wochenschr. 1999;149(19-20):561–3.

    CAS  PubMed  Google Scholar 

  22. Kayıran S, Dursun E, Dursun N, Ermutlu N, Karamürsel S. Neurofeedback intervention in fibromyalgia syndrome; a randomized, controlled, rater blind clinical trial. Appl Psychophysiol Biofeedback. 2010 Dec;35(4):293–302.

    Article  PubMed  Google Scholar 

  23. Santoro M, Cronan T. A systematic review of neurofeedback as a treatment for fibromyalgia syndrome symptoms. J Musculoskelet Pain. 2014 Sep;22(3):286–300.

    Article  Google Scholar 

  24. Jones JE, Hermann BP, Barry JJ, Gilliam F, Kanner AM, Meador KJ. Clinical assessment of axis I psychiatric morbidity in chronic epilepsy: a multicenter investigation. J Neuropsychiatry Clin Neurosci. 2005 Spr;17(2):172–9.

    Article  PubMed  Google Scholar 

  25. Kimiskidis VK, Valeta T. Epilepsy and anxiety: epidemiology, classification, aetiology, and treatment. Epileptic Disord. 2012 Sep;14(3):248–56.

    PubMed  Google Scholar 

  26. Johnson EK, Jones JE, Seidenberg M, Hermann BP. The relative impact of anxiety, depression, and clinical seizure features on health-related quality of life in epilepsy. Epilepsia. 2004 May;45(5):544–50.

    Article  PubMed  Google Scholar 

  27. Kanner AM, Barry JJ, Gilliam F, Hermann B, Meador KJ. Anxiety disorders, subsyndromic depressive episodes, and major depressive episodes: do they differ on their impact on the quality of life of patients with epilepsy? Epilepsia. 2010 Jul;51(7):1152–8.

    Article  PubMed  Google Scholar 

  28. Michaelis R, Tang V, Wagner J, Modi A, LaFrance W Jr, Goldstein L, et al. Psychological treatments for people with epilepsy. Cochrane Database Syst Rev. 2017;10

    Google Scholar 

  29. Lundgren T, Dahl J, Hayes SC. Evaluation of mediators of change in the treatment of epilepsy with acceptance and commitment therapy. J Behav Med. 2008 Jun;31(3):225–35.

    Article  PubMed  Google Scholar 

  30. Gundy JM, Woidneck MR, Pratt KM, Christian AW, Twohig MP. Acceptance and commitment therapy: state of evidence in the field of health psychology. Sci Rev Ment Health Pract. 2011;8(2):23–35.

    Google Scholar 

  31. Dewhurst E, Novakova B, Reuber M. A prospective service evaluation of acceptance and commitment therapy for patients with refractory epilepsy. Epilepsy Behav. 2015 May;46:234–41.

    Article  PubMed  Google Scholar 

  32. Mula M. Treatment of anxiety disorders in epilepsy: an evidence-based approach. Epilepsia. 2013 Mar;54(Suppl 1):13–8.

    Article  CAS  PubMed  Google Scholar 

  33. Macrodimitris S, Wershler J, Hatfield M, Hamilton K, Backs-Dermott B, Mothersill K, et al. Group cognitive-behavioral therapy for patients with epilepsy and comorbid depression and anxiety. Epilepsy Behav. 2011 Jan;20(1):83–8.

    Article  CAS  PubMed  Google Scholar 

  34. Gandy M, Sharpe L, Nicholson Perry K, Thayer Z, Miller L, Boserio J, et al. Cognitive behaviour therapy to improve mood in people with epilepsy: a randomised controlled trial. Cogn Behav Ther. 2014 Apr;43(2):153–66.

    Article  PubMed  Google Scholar 

  35. Tang V, Poon WS, Kwan P. Mindfulness-based therapy for drug-resistant epilepsy: an assessor-blinded randomized trial. Neurology. 2015 Sep;85(13):1100–7.

    Article  CAS  PubMed  Google Scholar 

  36. Fried R, Fox MC, Carlton RM. Effect of diaphragmatic respiration with end-tidal CO2 biofeedback on respiration, EEG, and seizure frequency in idiopathic epilepsy. Ann NY Acad Sci. 1990 Sep;602(1):67–96.

    Article  CAS  PubMed  Google Scholar 

  37. Nagai Y, Trimble MR. Long-term effects of electrodermal biofeedback training on seizure control in patients with drug-resistant epilepsy: two case reports. Epilepsy Res. 2014 Jan;108(1):149–52.

    Article  PubMed  Google Scholar 

  38. Uhlmann C, Fröscher W. Biofeedback treatment in patients with refractory epilepsy: changes in depression and control orientation. Seizure. 2001 Jan;10(1):34–8.

    Article  CAS  PubMed  Google Scholar 

  39. Smith KJ, Peterson MD, O’Connell NE, Victor C, Liverani S, Anokye N, et al. Risk of depression and anxiety in adults with cerebral palsy. JAMA Neurol. 2019;76(3):294–300.

    Article  PubMed  Google Scholar 

  40. Britner PA, Morog MC, Pianta RC, Marvin RS. Stress and coping: a comparison of self-report measures of functioning in families of young children with cerebral palsy or no medical diagnosis. J Child Fam Stud. 2003 Sep;12(3):335–48.

    Article  Google Scholar 

  41. Manuel J, Naughton MJ, Balkrishnan R, Smith BP, Koman LA. Stress and adaptation in mothers of children with cerebral palsy. J Pediatr Psychol. 2003 Apr;28(3):197–201.

    Article  PubMed  Google Scholar 

  42. Wanamaker CE, Glenwick DS. Stress, coping, and perceptions of child behavior in parents of preschoolers with cerebral palsy. Rehabil Psychol. 1998 Win;43(4):297–312.

    Article  Google Scholar 

  43. Wiley R, Renk K. Psychological correlates of quality of life in children with cerebral palsy. J Dev Phys Disabil. 2007 Oct;19(5):427–47.

    Article  Google Scholar 

  44. Roux G, Sofronoff K, Sanders M. A randomized controlled trial of group Stepping Stones Triple P: a mixed-disability trial. Fam Process. 2013 Sep;52(3):411–24.

    Article  PubMed  Google Scholar 

  45. Whittingham K, Sanders M, McKinlay L, Boyd RN. Interventions to reduce behavioral problems in children with cerebral palsy: an RCT. Pediatrics. 2014 May;133(5):e1249–57.

    Article  PubMed  Google Scholar 

  46. Whittingham K, Sanders MR, McKinlay L, Boyd RN. Parenting intervention combined with acceptance and commitment therapy: a trial with families of children with cerebral palsy. J Pediatr Psychol. 2016 Jun;41(5):531–42.

    Article  PubMed  Google Scholar 

  47. Peterman JS, Hoff AL, Gosch E, Kendall PC. Cognitive-behavioral therapy for anxious youth with a physical disability: a case study. Clin Case Stud. 2015 Jun;14(3):210–26.

    Article  Google Scholar 

  48. Silber LD, Howard J. Systematic desensitization with a cerebral palsied college student. Psychotherapy. 1972 Spr;9(1):17.

    Article  Google Scholar 

  49. Engel JM, Jensen MP, Schwartz L. Outcome of biofeedback-assisted relaxation for pain in adults with cerebral palsy: preliminary findings. Appl Psychophysiol Biofeedback. 2004 Jun;29(2):135–40.

    Article  PubMed  Google Scholar 

  50. Davis E, Davies B, Wolfe R, Raadsveld R, Heine B, Thomason P, et al. A randomized controlled trial of the impact of therapeutic horse riding on the quality of life, health, and function of children with cerebral palsy. Dev Med Child Neurol. 2009 Feb;51(2):111–9.

    Article  CAS  PubMed  Google Scholar 

  51. Mak C, Whittingham K, Cunnington R, Boyd RN. Effect of mindfulness yoga programme MiYoga on attention, behaviour, and physical outcomes in cerebral palsy: a randomized controlled trial. Dev Med Child Neurol. 2018 Sep;60(9):922–32.

    Article  PubMed  Google Scholar 

  52. Fass R, Achem S. Noncardiac chest pain: epidemiology, natural course and pathogenesis. J Neurogastroenterol Motil. 2011 Apr;17(2):110–23.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Pope C, Ziebland S, Mays N. Qualitative research in health care: analysing qualitative data. BMJ. 2000 Jan;320(7227):114–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. Thurston RC, Keefe FJ, Bradley L, Rama Krishnan KR, Caldwell DS. Chest pain in the absence of coronary artery disease: a biopsychosocial perspective. Pain. 2001 Aug;93(2):95–100.

    Article  CAS  PubMed  Google Scholar 

  55. Eslick G, Talley N. Non-cardiac chest pain: predictors of health care seeking, the types of health care professional consulted, work absenteeism and interruption of daily activities. Aliment Pharmacol Ther. 2004 Oct;20(8):909–15.

    Article  CAS  PubMed  Google Scholar 

  56. Eslick G, Talley N. Gastroesophageal reflux disease (GERD): risk factors, and impact on quality of life – a population-based study. J Clin Gastroenterol. 2009 Feb;43(2):111–7.

    Article  PubMed  Google Scholar 

  57. Eifert G, Forsyth J, Zvolensky M, Lejuez C. Moving from the laboratory to the real world and back again: increasing the relevance of laboratory examinations of anxiety sensitivity. Behav Ther. 1999 Spr;30(2):273–83.

    Article  Google Scholar 

  58. Potts SG, Bass CM. Psychological morbidity in patients with chest pain and normal or near-normal coronary arteries: a long-term follow-up study. Psychol Med. 1995 Mar;25(2):339–47.

    Article  CAS  PubMed  Google Scholar 

  59. Barsky AJ. Palpitations, cardiac awareness and panic disorder. Am J Med. 1992 Jan;92(1):S31–4.

    Article  Google Scholar 

  60. White KS, Raffa SD, Jakle KR, Stoddard JA, Barlow DH, Brown TA, et al. Morbidity of DSM-IV Axis I disorders in patients with noncardiac chest pain: psychiatric morbidity linked with increased pain and health care utilization. J Consult Clin Psychol. 2008 Jun;76(3):422–30.

    Article  PubMed  Google Scholar 

  61. White K, Craft J, Gervino E. Anxiety and hypervigilance to cardiopulmonary sensations in non-cardiac chest pain patients with and without psychiatric disorders. Behav Res Ther. 2010 May;48(5):394–401.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Mourad G, Strömberg A, Johansson P, Jaarsma T. Depressive symptoms, cardiac anxiety, and fear of body sensations in patients with non-cardiac chest pain, and their relation to healthcare-seeking behavior: a cross-sectional study. Patient. 2016 Feb;9(1):69–77.

    Article  PubMed  Google Scholar 

  63. Richter JE, Bradley LA, Castell DO. Esophageal chest pain: current controversies in pathogenesis, diagnosis, and therapy. Ann Intern Med. 1989 Jan;110(1):66–78.

    Article  CAS  PubMed  Google Scholar 

  64. Barsky AJ, Cleary PD, Sarnie MK, Ruskin JN. Panic disorder, palpitations, and the awareness of cardiac activity. J Nerv Ment Dis. 1994 Feb;182(2):63–71.

    Article  CAS  PubMed  Google Scholar 

  65. Kisely S, Campbell LA, Yelland MJ, Paydar A. Psychological interventions for symptomatic management of non-specific chest pain in patients with normal coronary anatomy. Cochrane Database Syst Rev. 2015 Jun;6:CD004101.

    Google Scholar 

  66. Jonsbu E, Dammen T, Morken G, Moum T, Martinsen EW. Short-term cognitive behavioral therapy for non-cardiac chest pain and benign palpitations: a randomized controlled trial. J Psychosom Res. 2011 Feb;70(2):117–23.

    Article  PubMed  Google Scholar 

  67. Beck JS. Cognitive behavior therapy: basics and beyond. 2nd ed. New York: Guilford Press; 2011.

    Google Scholar 

  68. Spinhoven P, Van der Does A, Van Dijk E, Van Rood Y. Heart-focused anxiety as a mediating variable in the treatment of noncardiac chest pain by cognitive-behavioral therapy and paroxetine. J Psychosom Res. 2010 Sep;69(3):227–35.

    Article  PubMed  Google Scholar 

  69. Mulder R, Zarifeh J, Boden J, Lacey C, Tyrer P, Tyrer H. An RCT of brief cognitive therapy versus treatment as usual in patients with non-cardiac chest pain. Int J Cardiol. 2019 Feb 5; https://doi.org/10.1016/j.ijcard.2019.01.067.

    Article  PubMed  Google Scholar 

  70. Lahmann C, Loew T, Tritt K, Nickel M. Efficacy of functional relaxation and patient education in the treatment of somatoform heart disorders: a randomized, controlled clinical investigation. Psychosomatics. 2008 Sep–Oct;49(5):378–85.

    Article  PubMed  Google Scholar 

  71. Webster R, Thompson AR, Norman P, Goodacre S. The acceptability and feasibility of an anxiety reduction intervention for emergency department patients with non-cardiac chest pain. Psychol Health Med. 2017 Jan;22(1):1–11.

    Article  PubMed  Google Scholar 

  72. Schey R, Villarreal A, Fass R. Noncardiac chest pain: current treatment. Gastroenterol Hepatol (N Y). 2007 Apr;3(4):255–62.

    Google Scholar 

  73. Keefe F, Shelby R, Somers T, Varia I, Blazing M, Waters S, et al. Effects of coping skills training and sertraline in patients with non-cardiac chest pain: a randomized controlled study. Pain. 2011 Apr;152(4):730–41.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Varia I, Logue E, O’Connor C, Newby K, Wagner H, Davenport C, et al. Randomized trial of sertraline in patients with unexplained chest pain of noncardiac origin. Am Heart J. 2000 Sep;140(3):367–72.

    Article  CAS  PubMed  Google Scholar 

  75. Kharroubi AT, Darwish HM. Diabetes mellitus: the epidemic of the century. World J Diabetes. 2015 Jun;6(6):850–67.

    Article  PubMed  PubMed Central  Google Scholar 

  76. American Diabetes Association. Standards of medical care in diabetes-2018. Diabetes Care. 2018;41

    Google Scholar 

  77. Anderson RJ, Grigsby AB, Freedland KE, Groot MD, Mcgill JB, Clouse RE, et al. Anxiety and poor glycemic control: a meta-analytic review of the literature. Int J Psychiatry Med. 2002;32(3):235–47.

    Article  PubMed  Google Scholar 

  78. Buchberger B, Huppertz H, Krabbe L, Lux B, Mattivi JT, Siafarikas A. Symptoms of depression and anxiety in youth with type 1 diabetes: a systematic review and meta-analysis. Psychoneuroendocrinology. 2016 Aug;70:70–84.

    Article  PubMed  Google Scholar 

  79. Grigsby AB, Anderson RJ, Freedland KE, Clouse RE, Lustman PJ. Prevalence of anxiety in adults with diabetes: a systematic review. J Psychosom Res. 2002 Dec;53(6):1053–60.

    Article  PubMed  Google Scholar 

  80. Smith KJ, Béland M, Clyde M, Gariépy G, Pagé V, Badawi G, et al. Association of diabetes with anxiety: a systematic review and meta-analysis. J Psychosom Res. 2013 Feb;74(2):89–99.

    Article  PubMed  Google Scholar 

  81. Rubin RR, Peyrot M. Psychological issues and treatments for people with diabetes. J Clin Psychol. 2001 Apr;57(4):457–78.

    Article  CAS  PubMed  Google Scholar 

  82. Cramer JA. A systematic review of adherence with medications for diabetes. Diabetes Care. 2004 May;27(5):1218–24.

    Article  PubMed  Google Scholar 

  83. Wani AL, Ara A, Bhat SA. Blood injury and injection phobia: the neglected one. Behav Neurol. 2014;2014:471340.

    Article  PubMed  PubMed Central  Google Scholar 

  84. Ducat L, Philipson LH, Anderson BJ. The mental health comorbidities of diabetes. JAMA. 2014 Aug;312(7):691–2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington: American Psychiatric Publishing; 2013.

    Book  Google Scholar 

  86. Meuret AE, Rosenfield D, Wilhelm FH, Zhou E, Conrad A, Ritz T, et al. Do unexpected panic attacks occur spontaneously? Biol Psychiatry. 2011 Nov;70(10):985–91.

    Article  PubMed  PubMed Central  Google Scholar 

  87. Ayala ES, Meuret AE, Ritz T. Treatments for blood-injury-injection phobia: a critical review of current evidence. J Psychiatr Res. 2009 Oct;43(15):1235–42.

    Article  PubMed  Google Scholar 

  88. Bienvenu OJ, Eaton WW. The epidemiology of blood-injection-injury phobia. Psychol Med. 1998 Sep;28(5):1129–36.

    Article  CAS  PubMed  Google Scholar 

  89. Alam U, Asghar O, Azmi S, Malik RA. General aspects of diabetes mellitus. Handb Clin Neurol. 2014;126:211–22.

    Article  PubMed  Google Scholar 

  90. Asche C, LaFleur J, Conner C. A review of diabetes treatment adherence and the association with clinical and economic outcomes. Clin Ther. 2011 Jan;33(1):74–109.

    Article  PubMed  Google Scholar 

  91. Harkness E, Macdonald W, Valderas J, Coventry P, Gask L, Bower P. Identifying psychosocial interventions that improve both physical and mental health in patients with diabetes: a systematic review and meta-analysis. Diabetes Care. 2010 Apr;33(4):926–30.

    Article  PubMed  PubMed Central  Google Scholar 

  92. Pascoe MC, Thompson DR, Castle DJ, Jenkins ZM, Ski CF. Psychosocial interventions and wellbeing in individuals with diabetes mellitus: a systematic review and meta-analysis. Front Psychol. 2017 Dec;8:2063.

    Article  PubMed  PubMed Central  Google Scholar 

  93. Amsberg S, Anderbro T, Wredling R, Lisspers J, Lins P-E, Adamson U, et al. A cognitive behavior therapy-based intervention among poorly controlled adult type 1 diabetes patients – a randomized controlled trial. Patient Educ Couns. 2009 Oct;77(1):72–80.

    Article  PubMed  Google Scholar 

  94. Gregg JA, Callaghan GM, Hayes SC, Glenn-Lawson JL. Improving diabetes self-management through acceptance, mindfulness, and values: a randomized controlled trial. J Consult Clin Psychol. 2007 Apr;75(2):336–43.

    Article  PubMed  Google Scholar 

  95. O’Donohue W, Snipes C, Soto C. A case study of overselling psychotherapy: an ACT intervention for diabetes management. J Contemp Psychother. 2016 Mar;46(1):15–25.

    Article  Google Scholar 

  96. Rosen GM, Lilienfeld SO. On the failure of psychology to advance self-help: acceptance and commitment therapy (ACT) as a case example. J Contemp Psychother. 2016;46(2):71–7.

    Article  Google Scholar 

  97. Ismail K, Winkley K, Rabe-Hesketh S. Systematic review and meta-analysis of randomised controlled trials of psychological interventions to improve glycaemic control in patients with type 2 diabetes. Lancet. 2004 May;363(9421):1589–97.

    Article  PubMed  Google Scholar 

  98. Welch G, Shayne R. Interactive behavioral technologies and diabetes self-management support: recent research findings from clinical trials. Curr Diab Rep. 2006 Apr;6(2):130–6.

    Article  PubMed  Google Scholar 

  99. Villamil-Salcedo V, Vargas-Terrez BE, Caraveo-Anduaga J, González-Olvera J, Díaz-Anzaldúa A, Cortés-Sotres J, et al. Glucose and cholesterol stabilization in patients with type 2 diabetes mellitus with depressive and anxiety symptoms by problem-solving therapy in primary care centers in Mexico City. Prim Health Care Res Dev. 2018 Jan;19(1):33–41.

    Article  PubMed  Google Scholar 

  100. Fadgyas-Stanculete M, Buga AM, Popa-Wagner A, Dumitrascu DL. The relationship between irritable bowel syndrome and psychiatric disorders: from molecular changes to clinical manifestations. J Mol Psychiatry. 2014 Jun;2(1):4.

    Article  PubMed  PubMed Central  Google Scholar 

  101. Lydiard RB. Irritable bowel syndrome, anxiety, and depression: what are the links? J Clin Psychiatry. 2001;62(Suppl 8):38–45.

    PubMed  Google Scholar 

  102. Lydiard RB, Laraia MT, Howell EF, Ballenger JC. Can panic disorder present as irritable bowel syndrome? J Clin Psychiatry. 1986 Sep;47(9):470–3.

    CAS  PubMed  Google Scholar 

  103. Lydiard B, Greenwald S, Weissman M, Johnson J, Drossman D, Ballenger J. Panic disorder and gastrointestinal symptoms: findings from the NIMH Epidemiologic Catchment Area project. Am J Psychiatry. 1994 Jan;151(1):64–70.

    Article  CAS  PubMed  Google Scholar 

  104. Tollefson GD, Luxenberg M, Valentine R, Dunsmore G, Tollefson SL. An open label trial of alprazolam in comorbid irritable bowel syndrome and generalized anxiety disorder. J Clin Psychiatry. 1991 Dec;52(12):502–8.

    CAS  PubMed  Google Scholar 

  105. Miller I. The gut–brain axis: historical reflections. Microb Ecol Health Dis. 2018;29(1):1542921.

    Article  PubMed  PubMed Central  Google Scholar 

  106. Halpert A, Drossman D. Biopsychosocial issues in irritable bowel syndrome. J Clin Gastroenterol. 2005 Sep;39(8):665–9.

    Article  PubMed  Google Scholar 

  107. Oudenhove LV, Levy RL, Crowell MD, Drossman DA, Halpert AD, Keefer L, et al. Biopsychosocial aspects of functional gastrointestinal disorders: how central and environmental processes contribute to the development and expression of functional gastrointestinal disorders. Gastroenterology. 2016 May;150(6):1355–67.

    Article  Google Scholar 

  108. Tanaka Y, Kanazawa M, Fukudo S, Drossman DA. Biopsychosocial model of irritable bowel syndrome. J Neurogastroenterol Motil. 2011 Apr;17(2):131–9.

    Article  PubMed  PubMed Central  Google Scholar 

  109. Chatoo M, Li Y, Ma Z, Coote J, Du J, Chen X. Involvement of corticotropin-releasing factor and receptors in immune cells in irritable bowel syndrome. Front Endocrinol (Lausanne). 2018 Feb;9:21.

    Article  Google Scholar 

  110. Taché Y, Kiank C, Stengel A. A role for corticotropin-releasing factor in functional gastrointestinal disorders. Curr Gastroenterol Rep. 2009 Aug;11(4):270–7.

    Article  PubMed  Google Scholar 

  111. Lacy B, Patel N. Rome criteria and a diagnostic approach to irritable bowel syndrome. J Clin Med. 2017 Nov;6(11):99.

    Article  PubMed Central  Google Scholar 

  112. Roy-Byrne PP, Davidson KW, Kessler RC, Asmundson GJ, Goodwin RD, Kubzansky L, et al. Anxiety disorders and comorbid medical illness. Gen Hosp Psychiatry. 2008 May-Jun;30(3):208–25.

    Article  PubMed  Google Scholar 

  113. Thakur ER, Gurtman MB, Keefer L, Brenner DM, Lackner JM. Gender differences in irritable bowel syndrome: the interpersonal connection. Neurogastroenterol Motil. 2015 Oct;27(10):1478–86.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  114. Garakani A, Win T, Virk S, Gupta S, Kaplan D, Masand PS. Comorbidity of irritable bowel syndrome in psychiatric patients: a review. Am J Ther. 2003 Jan-Feb;10(1):61–7.

    Article  PubMed  Google Scholar 

  115. Gros DF, Antony MM, Mccabe RE, Swinson RP. Frequency and severity of the symptoms of irritable bowel syndrome across the anxiety disorders and depression. J Anxiety Disord. 2009 Mar;23(2):290–6.

    Article  PubMed  Google Scholar 

  116. Kenwright M, Mcdonald J, Talbot J, Janjua K. Do symptoms of irritable bowel syndrome improve when patients receive cognitive behavioural therapy for co-morbid anxiety disorders in a primary care psychological therapy (IAPT) service? Behav Cogn Psychother. 2017 Sep;45(5):433–47.

    Article  PubMed  Google Scholar 

  117. Whitehead WE, Palsson O, Jones KR. Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications? Gastroenterology. 2002 Apr;122(4):1140–56.

    Article  PubMed  Google Scholar 

  118. Lee S, Wu J, Ma YL, Tsang A, Guo W-J, Sung J. Irritable bowel syndrome is strongly associated with generalized anxiety disorder: a community study. Aliment Pharmacol Ther. 2009 Sep;30(6):643–51.

    Article  CAS  PubMed  Google Scholar 

  119. Inadomi JM, Fennerty MB, Bjorkman D. Systematic review: the economic impact of irritable bowel syndrome. Aliment Pharmacol Ther. 2003 Oct;18(7):671–82.

    Article  CAS  PubMed  Google Scholar 

  120. Longstreth G, Wilson A, Knight K, Wong J, Chiou CF, Barghout V, et al. Irritable bowel syndrome, health care use, and costs: a U.S. managed care perspective. Am J Gastroenterol. 2003 Mar;98(3):600–7.

    Article  PubMed  Google Scholar 

  121. Paré P, Gray J, Lam S, Balshaw R, Khorasheh S, Barbeau M, et al. Health-related quality of life, work productivity, and health care resource utilization of subjects with irritable bowel syndrome: baseline results from LOGIC (Longitudinal Outcomes Study of Gastrointestinal Symptoms in Canada), a naturalistic study. Clin Ther. 2006 Oct;28(10):1726–35.

    Article  PubMed  Google Scholar 

  122. Lackner JM, Mesmer C, Morley S, Dowzer C, Hamilton S. Psychological treatments for irritable bowel syndrome: a systematic review and meta-analysis. J Consult Clin Psychol. 2004 Dec;72(6):1100–13.

    Article  PubMed  Google Scholar 

  123. Laird KT, Tanner-Smith EE, Russell AC, Hollon SD, Walker LS. Short-term and long-term efficacy of psychological therapies for irritable bowel syndrome: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2016 Jul;14(7):937–47.

    Article  PubMed  Google Scholar 

  124. Laird KT, Tanner-Smith EE, Russell AC, Hollon SD, Walker LS. Comparative efficacy of psychological therapies for improving mental health and daily functioning in irritable bowel syndrome: a systematic review and meta-analysis. Clin Psychol Rev. 2017 Feb;51:142–52.

    Article  PubMed  Google Scholar 

  125. Ljótsson B, Andréewitch S, Hedman E, Rück C, Andersson G, Lindefors N. Exposure and mindfulness based therapy for irritable bowel syndrome – an open pilot study. J Behav Ther Exp Psychiatry. 2010 Sep;41(3):185–90.

    Article  PubMed  Google Scholar 

  126. Kinsinger SW. Cognitive-behavioral therapy for patients with irritable bowel syndrome: current insights. Psychol Res Behav Manag. 2017 Jul;10:231–7.

    Article  PubMed  PubMed Central  Google Scholar 

  127. Lee HH, Choi YY, Choi MG. The efficacy of hypnotherapy in the treatment of irritable bowel syndrome: a systematic review and meta-analysis. J Neurogastroenterol Motil. 2014 Apr;20(2):152–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  128. Hazlett-Stevens H, Craske MG, Mayer EA, Chang L, Naliboff BD. Prevalence of irritable bowel syndrome among university students: the roles of worry, neuroticism, anxiety sensitivity and visceral anxiety. J Psychosom Res. 2003 Dec;55(6):501–5.

    Article  PubMed  Google Scholar 

  129. Jerndal P, Ringström G, Agerforz P, Karpefors M, Akkermans LM, Bayati A, et al. Gastrointestinal-specific anxiety: an important factor for severity of GI symptoms and quality of life in IBS. Neurogastroenterol Motil. 2010 Jun;22(6):646–e179.

    Article  CAS  PubMed  Google Scholar 

  130. Labus JS, Mayer EA, Chang L, Bolus R, Naliboff BD. The central role of gastrointestinal-specific anxiety in irritable bowel syndrome: further validation of the visceral sensitivity index. Psychosom Med. 2007 Jan;69(1):89–98.

    Article  PubMed  Google Scholar 

  131. Craske MG, Wolitzky-Taylor KB, Labus J, Wu S, Frese M, Mayer EA, et al. A cognitive-behavioral treatment for irritable bowel syndrome using interoceptive exposure to visceral sensations. Behav Res Ther. 2011 Jun;49(6–7):413–21.

    Article  PubMed  PubMed Central  Google Scholar 

  132. Altayar O, Sharma V, Prokop LJ, Sood A, Murad MH. Psychological therapies in patients with irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials. Gastroenterol Res Pract. 2015;2015:549308.

    Article  PubMed  PubMed Central  Google Scholar 

  133. Ford AC, Lacy BE, Harris LA, Quigley EMM, Moayyedi P. Effect of antidepressants and psychological therapies in irritable bowel syndrome: an updated systematic review and meta-analysis. Am J Gastroenterol. 2019 Jan;114(1):21–39.

    Article  PubMed  Google Scholar 

  134. Martens U, Enck P, Matheis A, Herzog W, Klosterhalfen S, Ruhl A, et al. Motivation for psychotherapy in patients with functional gastrointestinal disorders. Psychosomatics. 2010 May-Jun;51(3):225–9.

    Article  PubMed  Google Scholar 

  135. Palsson OS, Whitehead WE. Psychological treatments in functional gastrointestinal disorders: a primer for the gastroenterologist. Clin Gastroenterol Hepatol. 2013 Mar;11(3):208–16.

    Article  PubMed  Google Scholar 

  136. Sobin WH, Heinrich TW, Drossman DA. Central neuromodulators for treating functional GI disorders: a primer. Am J Gastroenterol. 2017 May;112(5):693–702.

    Article  CAS  PubMed  Google Scholar 

  137. Thiwan SI, Drossman DA. Treatment of functional GI disorders with psychotropic medicines: a review of evidence with a practical approach. Gastroenterol Hepatol (N Y). 2006 Sep;2(9):678–88.

    Google Scholar 

  138. Xiong N, Duan Y, Wei J, Mewes R, Leonhart R. Antidepressants vs. placebo for the treatment of functional gastrointestinal disorders in adults: a systematic review and meta-analysis. Front Psychiatry. 2018 Dec;9:659.

    Article  PubMed  PubMed Central  Google Scholar 

  139. Taché Y, Perdue MH. Role of peripheral CRF signalling pathways in stress-related alterations of gut motility and mucosal function. Neurogastroenterol Motil. 2004 Apr;16(Suppl 1):137–42.

    Article  PubMed  Google Scholar 

  140. Li X, Ding F, Luo P, Yang J, Liu Z, Liu J, et al. Study on the therapeutic effects of drug and cognitive-behavioral therapy on non-erosive reflux disease patients with emotional disorders. Front Psychiatry. 2018 May;9:115.

    Article  PubMed  PubMed Central  Google Scholar 

  141. Modlin I, Hunt RH, Malfertheiner P, Moayyedi P, Quigley EM, Tytgat GN, et al. Diagnosis and management of non-erosive reflux disease--the Vevey NERD Consensus Group. Digestion. 2009;80(2):74–88.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  142. Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006 Aug;101(8):1900–20.

    Article  PubMed  Google Scholar 

  143. Peery AF, Crockett SD, Barritt AS, Dellon ES, Eluri S, Gangarosa LM, et al. Burden of gastrointestinal, liver, and pancreatic diseases in the United States. Gastroenterology. 2015 Dec;149(7):1731–41.

    Article  PubMed  Google Scholar 

  144. Katz PO, Gerson LB, Vela MF. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 2013 Mar;108(3):308–28.

    Article  PubMed  Google Scholar 

  145. Martinez SD, Malagon IB, Garewal HS, Cui H, Fass R. Non-erosive reflux disease (NERD) – acid reflux and symptom patterns. Aliment Pharmacol Ther. 2003 Feb;17(4):537–45.

    Article  CAS  PubMed  Google Scholar 

  146. Mdi P, Fitzgerald R. Research advances in esophageal diseases: bench to bedside. F1000Prime Rep. 2013 Oct;5:44.

    Google Scholar 

  147. Riehl ME, Kinsinger S, Kahrilas PJ, Pandolfino JE, Keefer L. Role of a health psychologist in the management of functional esophageal complaints. Dis Esophagus. 2015;28(5):428–36.

    Article  CAS  PubMed  Google Scholar 

  148. Riehl ME, Chen JW. The proton pump inhibitor nonresponder: a behavioral approach to improvement and wellness. Curr Gastroenterol Rep. 2018 Jun;20(7):34.

    Article  PubMed  Google Scholar 

  149. Keefer L, Palsson OS, Pandolfino JE. Best practice update: incorporating psychogastroenterology into management of digestive disorders. Gastroenterology. 2018 Apr;154(5):1249–57.

    Article  PubMed  Google Scholar 

  150. Mcdonald-Haile J, Bradley LA, Bailey MA, Schan CA, Richter JE. Relaxation training reduces symptom reports and acid exposure in patients with gastroesophageal reflux disease. Gastroenterology. 1994 Jul;107(1):61–9.

    Article  CAS  PubMed  Google Scholar 

  151. Katzka DA. Simple office-based behavioral approach to patients with chronic belching. Dis Esophagus. 2013 Aug;26(6):570–3.

    Article  CAS  PubMed  Google Scholar 

  152. Hemmink GJ, Ten Cate L, Bredenoord AJ, Timmer R, Weusten BL, Smout AJ. Speech therapy in patients with excessive supragastric belching – a pilot study. Neurogastroenterol Motil. 2010 Jan;22(1):24–8.

    CAS  PubMed  Google Scholar 

  153. Glasinovic E, Wynter E, Arguero J, Ooi J, Nakagawa K, Yazaki E, et al. Treatment of supragastric belching with cognitive behavioral therapy improves quality of life and reduces acid gastroesophageal reflux. Am J Gastroenterol. 2018 Apr;113(4):539–47.

    Article  CAS  PubMed  Google Scholar 

  154. Meuret AE, Ritz T. Hyperventilation in panic disorder and asthma: empirical evidence and clinical strategies. Int J Psychophysiol. 2010 Oct;78(1):68–79.

    Article  PubMed  PubMed Central  Google Scholar 

  155. Davies SJ, Allgulander C. Anxiety and cardiovascular disease. Mod Trends Pharmacopsychiatry. 2013;29:85–97.

    Article  PubMed  Google Scholar 

  156. Meuret A, Kroll J, Ritz T. Panic disorder comorbidity with medical conditions and treatment implications. Annu Rev Clin Psychol. 2017 May;13(1):209–40.

    Article  PubMed  Google Scholar 

  157. Deacon B, Lickel J, Abramowitz JS. Medical utilization across the anxiety disorders. J Anxiety Disord. 2008;22(2):344–50.

    Article  PubMed  Google Scholar 

  158. Katon W. Panic disorder in the medical setting. Rockville: Department of Health and Human Services, Public Health Service, Alcohol, Drug Abuse and Mental Health Administration, National Institute of Mental Health; 1989.

    Google Scholar 

  159. Gadermann AM, Alonso J, Vilagut G, Zaslavsky AM, Kessler RC. Comorbidity and disease burden in the National Comorbidity Survey Replication (NCS-R). Depress Anxiety. 2012 Sep;29(9):797–806.

    Article  PubMed  PubMed Central  Google Scholar 

  160. Alonso J, Vilagut G, Chatterji S, Heeringa S, Schoenbaum M, Bedirhan Üstün T, et al. Including information about co-morbidity in estimates of disease burden: results from the World Health Organization World Mental Health Surveys. Psychol Med. 2011 Apr;41(4):873–86.

    Article  CAS  PubMed  Google Scholar 

  161. Kinley DJ, Cox BJ, Clara I, Goodwin RD, Sareen J. Panic attacks and their relation to psychological and physical functioning in Canadians: results from a nationally representative sample. Can J Psychiatry. 2009 Feb;54(2):113–22.

    Article  PubMed  Google Scholar 

  162. Klerman GL, Weissman MM, Ouellette R, Johnson J, Greenwald S. Panic attacks in the community. Social morbidity and health care utilization. JAMA. 1991 Feb;265(6):742–6.

    Article  CAS  PubMed  Google Scholar 

  163. Obrist PA. Presidential address, 1975. The cardiovascular-behavioral interaction – as it appears today. Psychophysiology. 1976 Mar;13(2):95–107.

    Article  CAS  PubMed  Google Scholar 

  164. Dimsdale JE. Psychological stress and cardiovascular disease. J Am Coll Cardiol. 2008 Apr;51(13):1237–46.

    Article  PubMed  PubMed Central  Google Scholar 

  165. Esler M. Depressive illness, the sympathetic nervous system and cardiac risk. J Hypertens. 2009 Dec;27(12):2349–50.

    Article  CAS  PubMed  Google Scholar 

  166. Tully PJ, Baune BT. Comorbid anxiety disorders alter the association between cardiovascular diseases and depression: the German National Health Interview and Examination Survey. Soc Psychiatry Psychiatr Epidemiol. 2014 May;49(5):683–91.

    Article  PubMed  Google Scholar 

  167. Müller-Tasch T, Frankenstein L, Holzapfel N, Schellberg D, Löwe B, Nelles M, et al. Panic disorder in patients with chronic heart failure. J Psychosom Res. 2008 Mar;64(3):299–303.

    Article  PubMed  Google Scholar 

  168. Emdin CA, Odutayo A, Wong CX, Tran J, Hsiao AJ, Hunn BH. Meta-analysis of anxiety as a risk factor for cardiovascular disease. Am J Cardiol. 2016 Aug;118(4):511–9.

    Article  PubMed  Google Scholar 

  169. Katerndahl DA. The association between panic disorder and coronary artery disease among primary care patients presenting with chest pain: an updated literature review. Prim Care Companion J Clin Psychiatry. 2008;10(4):276–85.

    Article  PubMed  PubMed Central  Google Scholar 

  170. Player MS, Peterson LE. Anxiety disorders, hypertension, and cardiovascular risk: a review. Int J Psychiatry Med. 2011;41(4):365–77.

    Article  PubMed  Google Scholar 

  171. Gomez-Caminero A, Blumentals WA, Russo LJ, Brown RR, Castilla-Puentes R. Does panic disorder increase the risk of coronary heart disease? A cohort study of a national managed care database. Psychosom Med. 2005 Sep–Oct;67(5):688–91.

    Article  PubMed  Google Scholar 

  172. Goodwin RD, Davidson KW, Keyes K. Mental disorders and cardiovascular disease among adults in the United States. J Psychiatr Res. 2009 Jan;43(3):239–46.

    Article  PubMed  Google Scholar 

  173. Meuret AE, White KS, Ritz T, Roth WT, Hofmann SG, Brown TA. Panic attack symptom dimensions and their relationship to illness characteristics in panic disorder. J Psychiatr Res. 2006 Sep;40(6):520–7.

    Article  PubMed  Google Scholar 

  174. Celano CM, Daunis DJ, Lokko HN, Campbell KA, Huffman JC. Anxiety disorders and cardiovascular disease. Curr Psychiatry Rep. 2016 Nov;18(11):101.

    Article  PubMed  PubMed Central  Google Scholar 

  175. Cohen BE, Edmondson D, Kronish IM. State of the art review: depression, stress, anxiety, and cardiovascular disease. Am J Hypertens. 2015 Nov;28(11):1295–302.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  176. Davies SJ, Ghahramani P, Jackson PR, Noble TW, Hardy PG, Hippisley-Cox J, et al. Association of panic disorder and panic attacks with hypertension. Am J Med. 1999 Oct;107(4):310–6.

    Article  CAS  PubMed  Google Scholar 

  177. Edmondson D, Richardson S, Falzon L, Davidson KW, Mills MA, Neria Y. Posttraumatic stress disorder prevalence and risk of recurrence in acute coronary syndrome patients: a meta-analytic review. PLoS One. 2012;7(6):e38915.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  178. Allabadi H, Alkaiyat A, Alkhayyat A, Hammoudi A, Odeh H, Shtayeh J, et al. Depression and anxiety symptoms in cardiac patients: a cross-sectional hospital-based study in a Palestinian population. BMC Public Health. 2019 Feb;19(1):232.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  179. Roest AM, Martens EJ, de Jonge P, Denollet J. Anxiety and risk of incident coronary heart disease: a meta-analysis. J Am Coll Cardiol. 2010 Jun;56(1):38–46.

    Article  PubMed  Google Scholar 

  180. Walters K, Rait G, Petersen I, Williams R, Nazareth I. Panic disorder and risk of new onset coronary heart disease, acute myocardial infarction, and cardiac mortality: cohort study using the general practice research database. Eur Heart J. 2008 Dec;29(24):2981–8.

    Article  PubMed  Google Scholar 

  181. Stein DJ, Aguilar-Gaxiola S, Alonso J, Bruffaerts R, de Jonge P, Liu Z, et al. Associations between mental disorders and subsequent onset of hypertension. Gen Hosp Psychiatry. 2014 Mar-Apr;36(2):142–9.

    Article  PubMed  Google Scholar 

  182. Cheng YF, Leu HB, Su CC, Huang CC, Chiang CH, Huang PH, et al. Association between panic disorder and risk of atrial fibrillation: a nationwide study. Psychosom Med. 2013 Jan;75(1):30–5.

    Article  PubMed  Google Scholar 

  183. Seldenrijk A, Vogelzangs N, Batelaan NM, Wieman I, van Schaik DJ, Penninx BJ. Depression, anxiety and 6-year risk of cardiovascular disease. J Psychosom Res. 2015 Feb;78(2):123–9.

    Article  PubMed  Google Scholar 

  184. Smoller JW, Pollack MH, Wassertheil-Smoller S, Jackson RD, Oberman A, Wong ND, et al. Panic attacks and risk of incident cardiovascular events among postmenopausal women in the Women’s Health Initiative Observational Study. Arch Gen Psychiatry. 2007 Oct;64(10):1153–60.

    Article  PubMed  Google Scholar 

  185. de Ornelas Maia AC, Soares-Filho G, Pereira V, Nardi AE, Silva AC. Psychiatric disorders and quality of life in patients with implantable cardioverter defibrillators: a systematic review. Prim Care Companion CNS Disord. 2013;15(2)

    Google Scholar 

  186. Magyar-Russell G, Thombs BD, Cai JX, Baveja T, Kuhl EA, Singh PP, et al. The prevalence of anxiety and depression in adults with implantable cardioverter defibrillators: a systematic review. J Psychosom Res. 2011 Oct;71(4):223–31.

    Article  PubMed  Google Scholar 

  187. Godemann F, Butter C, Lampe F, Linden M, Schlegl M, Schultheiss HP, et al. Panic disorders and agoraphobia: side effects of treatment with an implantable cardioverter/defibrillator. Clin Cardiol. 2004 Jun;27:321–6.

    Article  PubMed  Google Scholar 

  188. Richards SH, Anderson L, Jenkinson C, Whalley B, Rees K, Davies P, Bennett P, Liu Z, West R, Thompson DR, Taylor RS. Psychological interventions for coronary heart disease. Cochrane Database Syst Rev. 2017 Apr;28(4):CD002902.

    Google Scholar 

  189. Zheng X, Zheng Y, Ma J, Zhang M, Zhang Y, Liu X, et al. Effect of exercise-based cardiac rehabilitation on anxiety and depression in patients with myocardial infarction: a systematic review and meta-analysis. Heart Lung. 2019 Jan;48(1):1–7.

    Article  Google Scholar 

  190. Maia AC, Braga AA, Soares-Filho G, Pereira V, Nardi AE, Silva AC. Efficacy of cognitive behavioral therapy in reducing psychiatric symptoms in patients with implantable cardioverter defibrillator: an integrative review. Braz J Med Biol Res. 2014 Apr;47(4):265–72.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  191. Reavell J, Hopkinson M, Clarkesmith D, Lane DA. Effectiveness of cognitive behavioral therapy for depression and anxiety in patients with cardiovascular disease: a systematic review and meta-analysis. Psychosom Med. 2018 Oct;80(8):742–53.

    Article  PubMed  Google Scholar 

  192. Tully PJ, Selkow T, Bengel J, Rafanelli C. A dynamic view of comorbid depression and generalized anxiety disorder symptom change in chronic heart failure: the discrete effects of cognitive behavioral therapy, exercise, and psychotropic medication. Disabil Rehabil. 2015;37(7):585–92.

    Article  PubMed  Google Scholar 

  193. Blumenthal JA, Feger BJ, Smith PJ, Watkins LL, Jiang W, Davidson J, et al. Treatment of anxiety in patients with coronary heart disease: rationale and design of the UNderstanding the benefits of exercise and escitalopram in anxious patients WIth coroNary heart Disease (UNWIND) randomized clinical trial. Am Heart J. 2016 Jun;176:53–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  194. Oh H, Stickley A, Singh F, Koyanagi A. Self-reported asthma diagnosis and mental health: findings from the Collaborative Psychiatric Epidemiology Surveys. Psychiatry Res. 2019 Jan;271:721–5.

    Article  PubMed  Google Scholar 

  195. Goodwin RD, Pine DS. Respiratory disease and panic attacks among adults in the United States. Chest. 2002 Aug;122(2):645–50.

    Article  PubMed  Google Scholar 

  196. Goodwin RD, Olfson M, Shea S, Latingua RA, Carrasquilo O, Gameroff MJ, et al. Asthma and mental disorders in primary care. Gen Hosp Psychiatry. 2003 Nov–Dec;25(6):479–83.

    Article  PubMed  Google Scholar 

  197. Goodwin RD, Jacobi F, Thefeld W. Mental disorders and asthma in the community. Arch Gen Psychiatry. 2003 Nov;60(11):1125–30.

    Article  PubMed  Google Scholar 

  198. Hasler G, Gergen PJ, Kleinbaum DG, Ajdacic V, Gamma A, Eich D, et al. Asthma and panic in young adults: a 20-year prospective community study. Am J Respir Crit Care Med. 2005 Jun;171(11):1224–30.

    Article  PubMed  PubMed Central  Google Scholar 

  199. Niles AN, Dour HJ, Stanton AL, Roy-Byrne PP, Stein MB, Sullivan G, et al. Anxiety and depressive symptoms and medical illness among adults with anxiety disorders. J Psychosom Res. 2015 Feb;78(2):109–15.

    Article  PubMed  Google Scholar 

  200. Feldman JM, Siddique MI, Morales E, Kaminski B, Lu SE, Lehrer PM. Psychiatric disorder and asthma outcomes among high-risk inner-city patients. Psychosom Med. 2005 Nov-Dec;67(6):989–96.

    Article  PubMed  Google Scholar 

  201. Bouchard A, Ouellet K, Bacon SL, Lavoie, KL. Psychiatric morbidity in COPD and asthma patients presenting to the emergency room for acute exacerbations. Paper presented at: 17th Annual Meeting of the International Society for Advancement of Respiratory Psychophysiology; 2010 September 25-27; New York City, NY.

    Google Scholar 

  202. Goodwin RD, Wamboldt MZ, Pine DS. Lung disease and internalizing disorders. Is childhood abuse a shared etiologic factor? J Psychosom Res. 2003 Sep;55(3):215–9.

    Article  PubMed  Google Scholar 

  203. Katon WJ, Richardson L, Lozano P, McCauley E. The relationship of asthma and anxiety disorders. Psychosom Med. 2004 May-Jun;66(3):349–55.

    PubMed  Google Scholar 

  204. Halterman JS, Conn KM, Forbes-Jones E, Fagnano M, Hightower AD, Szilagyi PG. Behavior problems among inner-city children with asthma: findings from a community-based sample. Pediatrics. 2006 Feb;117(2):e192–9.

    Article  PubMed  Google Scholar 

  205. Craske MG, Poulton R, Tsao JC, Plotkin D. Paths to panic disorder/agoraphobia: An exploratory analysis from age 3 to 21 in an unselected birth cohort. J Am Acad Child Adolesc Psychiatry. 2001 May;40(5):556–63.

    Article  CAS  PubMed  Google Scholar 

  206. Meuret AE, Ehrenreich JT, Pincus DB, Ritz T. Prevalence and correlates of asthma in children with internalizing psychopathology. Depress Anxiety. 2006;23(8):502–8.

    Article  PubMed  Google Scholar 

  207. Battaglia M, Ogliari A. Anxiety and panic: from human studies to animal research and back. Neurosci Biobehav Rev. 2005 Feb;29(1):169–79.

    Article  PubMed  Google Scholar 

  208. Dirks JF, Schraa JC, Brown EL, Kinsman RA. Psycho-maintenance in asthma: hospitalization rates and financial impact. Br J Med Psychol. 1980 Dec;53(4):349–54.

    Article  CAS  PubMed  Google Scholar 

  209. Ritz T, Steptoe A, DeWilde S, Costa M. Emotions and stress increase respiratory resistance in asthma. Psychosom Med. 2000 May–Jun;62(3):401–12.

    Article  CAS  PubMed  Google Scholar 

  210. Ritz T, Kullowatz A, Goldman MD, Smith HJ, Kanniess F, Dahme B, et al. Airway response to emotional stimuli in asthma: the role of the cholinergic pathway. J Appl Physiol (1985). 2010 Jun;108(6):1542–9.

    Article  Google Scholar 

  211. Ritz T, Wilhelm FH, Meuret AE, Gerlach AL, Roth WT. Airway response to emotion- and disease-specific films in asthma, blood phobia, and health. Psychophysiology. 2011 Jan;48(1):121–35.

    Article  PubMed  PubMed Central  Google Scholar 

  212. Sandberg S, Paton JY, Ahola S, McCann DC, McGuinness D, Hillary CR, et al. The role of acute and chronic stress in asthma attacks in children. Lancet. 2000 Sep;356(9234):982–7.

    Article  CAS  PubMed  Google Scholar 

  213. Kullowaltz A, Rosefield D, Dahme B, Magnussen H, Kanniess F, Ritz T. Stress effects on lung function in asthma are mediated by changes in airway inflammation. Psychosom Med. 2008 May;70(4):468–75.

    Article  Google Scholar 

  214. Ritz T, Ayala ES, Trueba AF, Vance CD, Auchus RJ. Acute stress-induced increases in exhaled nitric oxide in asthma and their association with endogenous cortisol. Am J Respir Crit Care Med. 2011 Jan;183(1):26–30.

    Article  CAS  PubMed  Google Scholar 

  215. Potokar JP, Nutt DJ. Chest pain: panic attack or heart attack? Int J Clin Pract. 2000 Mar;54(2):110–4.

    CAS  PubMed  Google Scholar 

  216. Greenberg PE, Sisitsky T, Kessler RC, Finkelstein SN, Berndt ER, Davidson JR, et al. The economic burden of anxiety disorders in the 1990s. J Clin Psychiatry. 1999 Jul;60(7):427–35.

    Article  CAS  PubMed  Google Scholar 

  217. ten Brinke A, Ouwerkerk ME, Zwinderman AH, Spinhoven P, Bel EH. Psychopathology in patients with severe asthma is associated with increased health care utilization. Am J Respir Crit Care Med. 2001 Apr;163(5):1093–6.

    Article  PubMed  Google Scholar 

  218. Greaves CJ, Eiser C, Seamark D, Halpin DM. Attack context: an important mediator of the relationship between psychological status and asthma outcomes. Thorax. 2002 Mar;57(3):217–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  219. Pilipenko N, Karekla M, Georgiou A, Feldman J. Impact of psychiatric illness upon asthma patients’ health care utilization and illness control. Are all psychiatric comorbidities created equal? Psychol Health Med. 2016 Oct;21(7):787–99.

    Article  PubMed  Google Scholar 

  220. Johansson P, Dahlström U, Broström A. Factors and interventions influencing health-related quality of life in patients with heart failure: a review of the literature. Eur J Cardiovasc Nurs. 2006 Mar;5(1):5–15.

    Article  PubMed  Google Scholar 

  221. Sundh J, Wireklint P, Hasselgren M, Montgomery S, Ställberg B, Lisspers K, et al. Health-related quality of life in asthma patients - a comparison of two cohorts from 2005 and 2015. Respir Med. 2017 Nov;132:154–60.

    Article  PubMed  Google Scholar 

  222. Jaunay E, Consoli A, Greenfield B, Guilé JM, Mazet P, Cohen D. Treatment refusal in adolescents with severe chronic illness and borderline personality disorder. J Can Acad Child Adolesc Psychiatry. 2006 Aug;15(3):135–42.

    PubMed  PubMed Central  Google Scholar 

  223. Lehrer PM, Isenberg S, Hochron SM. Asthma and emotion: a review. J Asthma. 1993;30(1):5–21.

    Article  CAS  PubMed  Google Scholar 

  224. Lehrer PM, Karavidas MK, Lu SE, Feldman J, Kranitz L, Abraham S, et al. Psychological treatment of comorbid asthma and panic disorder: a pilot study. J Anxiety Disord. 2008 May;22(4):671–83.

    Article  PubMed  Google Scholar 

  225. Lehrer P, Carr RE, Smetankine A, Vaschillo E, Peper E, Porges S, et al. Respiratory sinus arrhythmia vs neck/trapezius EMG and incentive inspirometry biofeedback for asthma: a pilot study. Appl Psychophysiol Biofeedback. 1997 Jun;22(2):95–109.

    Article  CAS  PubMed  Google Scholar 

  226. Lehrer P, Feldman J, Giardino N, Song HS, Schmaling K. Psychological aspects of asthma. J Consult Clin Psychol. 2002 Jun;70(3):691–711.

    Article  PubMed  Google Scholar 

  227. Ritz T. Relaxation therapy in adult asthma. Is there new evidence for its effectiveness? Behav Modif. 2001 Sep;25(4):640–66.

    Article  CAS  PubMed  Google Scholar 

  228. Carr RE. Panic disorder and asthma: causes, effects and research implications. J Psychosom Res. 1998 Jan;44(1):43–52.

    Article  CAS  PubMed  Google Scholar 

  229. Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention: NHLIB/WHO workshop report. Bethesda: National Institutes of Health, National Heart, Lung and Blood Institute; 2005.

    Google Scholar 

  230. National Heart, Lung, and Blood Institute/National Asthma Education and Prevention Program. Expert panel report: guidelines for the diagnosis and management of asthma. Full report 2007. NIH Publication No. 07-4051. Bethesda: National Institutes of Health; 2007.

    Google Scholar 

  231. Bobb C, Ritz T. Do asthma patients in general practice profit from a structured allergy evaluation and skin testing? Respir Med. 2003 Nov;97(11):1180–7.

    Article  PubMed  Google Scholar 

  232. Bobb C, Ritz T, Rowlands G, Griffiths C. Effects of allergen and trigger factor avoidance advice in primary care on asthma control: a randomized-controlled trial. Clin Exp Allergy. 2010 Jan;40(1):143–52.

    CAS  PubMed  Google Scholar 

  233. Gibson PG, Powell H, Coughlan J, Wilson AJ, Abramson M, Haywood P, et al. Self-management education and regular practitioner review for adults with asthma. Cochrane Database Syst Rev. 2003;1:CD001117.

    Google Scholar 

  234. Kotses H, Bernstein IL, Bernstein DI, Reynolds RV, Korbee L, Wigal JK, et al. A self-management program for adult asthma. Part I: development and evaluation. J Allergy Clin Immunol. 1995 Feb;95(2):529–40.

    Article  CAS  PubMed  Google Scholar 

  235. Kotses H, Stout C, McConnaughy K, Winder JA, Creer TL. Evaluation of individualized asthma self-management programs. J Asthma. 1996;33(2):113–8.

    Article  CAS  PubMed  Google Scholar 

  236. Smyth JM, Stone AA, Hurewitz A, Kaell A. Effects of writing about stressful experiences on symptom reduction in patients with asthma or rheumatoid arthritis: a randomized trial. JAMA. 1999 Apr;281(14):1304–9.

    Article  CAS  PubMed  Google Scholar 

  237. Ritz T, Dahme B, Roth WT. Behavioral interventions in asthma: biofeedback techniques. J Psychosom Res. 2004 Jun;56(6):711–20.

    Article  PubMed  Google Scholar 

  238. Kew KM, Nashed M, Dulay V, Yorke J. Cognitive behavioural therapy (CBT) for adults and adolescents with asthma. Cochrane Database Syst Rev. 2016 Sep;9:CD011818.

    PubMed  Google Scholar 

  239. Lehrer PM, Vaschillo E, Vaschillo B, Lu SE, Scardella A, Siddique M, et al. Biofeedback treatment for asthma. Chest. 2004 Aug;126(2):352–61.

    Article  PubMed  Google Scholar 

  240. Ross CJ, Davis TM, MacDonald GF. Cognitive-behavioral treatment combined with asthma education for adults with asthma and coexisting panic disorder. Clin Nurs Res. 2005 May;14(2):131–57.

    Article  PubMed  Google Scholar 

  241. Barlow DH, Craske MG. Mastery of your anxiety and panic (MAP-3): client workbook for anxiety and panic. Oxford: Oxford University Press; 2000.

    Google Scholar 

  242. Yorke J, Adair P, Doyle AM, Dubrow-Marshall L, Fleming S, Holmes L, et al. A randomised controlled feasibility trial of Group Cognitive Behavioural Therapy for people with severe asthma. J Asthma. 2017 Jun;54(5):543–54.

    Article  PubMed  Google Scholar 

  243. Feldman JM, Matte L, Interian A, Lehrer PM, Lu SE, Scheckner B, et al. Psychological treatment of comorbid asthma and panic disorder in Latino adults: results from a randomized controlled trial. Behav Res Ther. 2016 Dec;87:142–54.

    Article  PubMed  PubMed Central  Google Scholar 

  244. Meuret AE, Wilhelm FH, Ritz T, Roth WT. Feedback of end-tidal pCO2 as a therapeutic approach for panic disorder. J Psychiatr Res. 2008 Jun;42(7):560–8.

    Article  PubMed  Google Scholar 

  245. Meuret AE, Rosenfield D, Seidel A, Bhaskara L, Hofmann SG. Respiratory and cognitive mediators of treatment change in panic disorder: evidence for intervention specificity. J Consult Clin Psychol. 2010 Oct;78(5):691–704.

    Article  PubMed  PubMed Central  Google Scholar 

  246. Ritz T, Rosenfield D, Steele AM, Millard MW, Meuret AE. Controlling asthma by training of Capnometry-Assisted Hypoventilation (CATCH) vs slow breathing: a randomized controlled trial. Chest. 2014 Nov;146(5):1237–47.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Alicia E. Meuret .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Meuret, A.E., Tunnell, N., Roque, A. (2020). Anxiety Disorders and Medical Comorbidity: Treatment Implications. In: Kim, YK. (eds) Anxiety Disorders. Advances in Experimental Medicine and Biology, vol 1191. Springer, Singapore. https://doi.org/10.1007/978-981-32-9705-0_15

Download citation

Publish with us

Policies and ethics