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Structural Immunology pp 207–226Cite as

NF-κB, IκB, and IKK: Integral Components of Immune System Signaling

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1172))

Abstract

The NF-κB (Nuclear Factor kappa B) transcription factor plays crucial roles in the regulation of numerous biological processes including development of the immune system, inflammation, and innate and adaptive immune responses. Control over the immune cell functions of NF-κB results from signaling through one of two different routes: the canonical and noncanonical NF-κB signaling pathways. Present at the end of both pathways are the proteins NF-κB, IκB, and the IκB kinase (IKK). These proteins work together to deliver the myriad outcomes that influence context-dependent transcriptional control in immune cells. In the present chapter, we review the structural information available on NF-κB, IκB, and IKK, the critical terminal components of the NF-κB signaling, in relation to their physiological function.

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Acknowledgements

Research is funded by the National Institutes of Health Grant GM085490 to GG. Biochemistry research at SDSU is supported in part by the California Metabolic Research Foundation.

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Authors and Affiliations

  1. Department of Chemistry & Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA

    Maria Carmen Mulero & Gourisankar Ghosh

  2. Structural Biochemistry Laboratory, Department of Chemistry & Biochemistry, San Diego State University, 5500 Campanile Drive, San Diego, CA, 92182, USA

    Tom Huxford

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Correspondence to Gourisankar Ghosh .

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Editors and Affiliations

  1. The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China

    Tengchuan Jin

  2. Department of Biological Science, Florida State University, Tallahassee, FL, USA

    Qian Yin

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Mulero, M.C., Huxford, T., Ghosh, G. (2019). NF-κB, IκB, and IKK: Integral Components of Immune System Signaling. In: Jin, T., Yin, Q. (eds) Structural Immunology. Advances in Experimental Medicine and Biology, vol 1172. Springer, Singapore. https://doi.org/10.1007/978-981-13-9367-9_10

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