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CD8+ T Cells in Immunotherapy, Radiotherapy, and Chemotherapy

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Abstract

CD8+ T-cell tumor infiltration is a favorable prognostic factor for a broad spectrum of human cancers. CD8+ T cells traffic to the tumor microenvironment and execute tumor clearance by recognizing specific tumor-associated antigens (TAA) on cancer cells and mediating tumor cytotoxic activity. PD-L1 and PD-1 checkpoint blockade unleashes the effector function of CD8+ T cells and results in significant objective response in patients with different types of cancer. Adoptive transfusion of ex vivo-expanded tumor-specific CD8+ T cells and of CAR-T cells has achieved important clinical response in specific cancer patient populations. In addition, recent studies have revealed that antibody-based biologically targeted therapy, radiotherapy, and chemotherapy mediate tumor regression via partially stimulating the innate and adaptive immunity. The convergence of immunotherapy, radiotherapy, and chemotherapy on CD8+ T cells provides scientific rationales for combination therapy to achieve better disease control and reduce adverse effect.

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Authors and Affiliations

  1. Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA

    Weimin Wang, Michael Green & Weiping Zou

  2. Department of Obstetrics and Gynecology, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA

    Weimin Wang & J. Rebecca Liu

  3. Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA

    Michael Green & Theodore S. Lawrence

  4. Graduate Programs in Immunology and Tumor Biology, University of Michigan, Ann Arbor, MI, 48109, USA

    Weiping Zou

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  1. Weimin Wang
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  2. Michael Green
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  4. Theodore S. Lawrence
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  5. Weiping Zou
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  1. Gustave Roussy Cancer Center , Villejuif Cedex, France

    Laurence Zitvogel

  2. Gustave Roussy Cancer Center , Villejuif Cedex, France

    Guido Kroemer

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Wang, W., Green, M., Rebecca Liu, J., Lawrence, T.S., Zou, W. (2018). CD8+ T Cells in Immunotherapy, Radiotherapy, and Chemotherapy. In: Zitvogel, L., Kroemer, G. (eds) Oncoimmunology. Springer, Cham. https://doi.org/10.1007/978-3-319-62431-0_3

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