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Stem Cell Migration pp 277–289Cite as

Pathways Implicated in Stem Cell Migration: The SDF-1/CXCR4 Axis

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 750))

Abstract

The hallmark of hematopoietic stem and progenitor cells (HSPCs) is their motility, which is essential for their function, such as recruitment upon demand. Stromal Derived Factor-1 (SDF-1, CXCL12) and its major receptor CXCR4 play major roles in stem cell motility and development. In vitro migration assays, implicating either gradients or cell surface-bound forms of SDF-1, are easy to perform and provide vital information regarding directional and random stem cell motility, which correlate with their repopulation potential in clinical and experimental transplantations. In vivo stem cell homing to the bone marrow, their retention, engraftment, and egress to the circulation, all involve SDF-1/CXCR4 interactions. Finally, other stem cell features such as stem cell survival and proliferation, are also dependent on the SDF-1/CXCR4 axis.

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Author information

Authors and Affiliations

  1. Immunology Department, The Weizmann Institute of Science, Rehovot, Israel

    Tsvee Lapidot

Authors
  1. Yaron Vagima
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  2. Kfir Lapid
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  3. Orit Kollet
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  4. Polina Goichberg
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  5. Ronen Alon
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  6. Tsvee Lapidot
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Corresponding author

Correspondence to Tsvee Lapidot .

Editor information

Editors and Affiliations

  1. Medical Center, Division of Experimental Hematology, Cincinnati Children's Hospital, Burnet Ave. 3333, Cincinnati, 45229, Ohio, USA

    Marie-Dominique Filippi

  2. Medical Center, Division of Experimental Hematology, Cincinnati Children's Hospital, Burnet Avenue 3333, Cincinnati, 45229, Ohio, USA

    Hartmut Geiger

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© 2011 Springer Science+Business Media, LLC

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Vagima, Y., Lapid, K., Kollet, O., Goichberg, P., Alon, R., Lapidot, T. (2011). Pathways Implicated in Stem Cell Migration: The SDF-1/CXCR4 Axis. In: Filippi, MD., Geiger, H. (eds) Stem Cell Migration. Methods in Molecular Biology, vol 750. Humana Press. https://doi.org/10.1007/978-1-61779-145-1_19

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  • DOI: https://doi.org/10.1007/978-1-61779-145-1_19

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-144-4

  • Online ISBN: 978-1-61779-145-1

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