Abstract
Squamous cell carcinoma (SCC) antigen, formerly referred to as TA-4, was originally purified from SCC of the uterine cervix (Kato and Torigoe, 1977). Since very few tumor markers have been prepared especially for squamous cell carcinoma, a radioimmunoassay of SCC antigen has become a promising aid for the management of squamous cell carcinoma in a variety of sites. Also, SCC antigen has provided new information regarding the Biological nature of squamous cells. Recent reports indicated that the expression of SCC antigen was closely related to the grade of differentiation of squamous cells (Ueda et al., 1984; Suehiro et al., 1986; Hoshina et al., 1986; Kimura et al., 1987; Gion et al., 1987; Cromback et al., 1989) and also to some environmental factors (Kobayashi, 1989). Thus, SCC antigen is an interesting marker not only for detecting malignant lesions, but also for understanding Biological behaviors of squamous cells. This chapter will review the clinical features of SCC antigen and discuss current understanding regarding the expression of SCC antigen in squamous cells.
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Kato, H. (1992). Squamous Cell Carcinoma Antigen. In: Sell, S. (eds) Serological Cancer Markers. Contemporary Biomedicine, vol 11. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0401-5_21
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DOI: https://doi.org/10.1007/978-1-4612-0401-5_21
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