Short CommunicationInterleukin-1 Receptor Cluster: Gene Organization ofIL1R2, IL1R1, IL1RL2(IL-1Rrp2),IL1RL1(T1/ST2), andIL18R1(IL-1Rrp) on Human Chromosome 2q
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Molecular and functional characterization of chicken interleukin 1 receptor 2 (chIL-1R2)
2023, Poultry ScienceCitation Excerpt :Recently, the family of decoy receptors has been identified and characterized as IL-18, TNF, and IL-27 (Mantovani et al., 2001). In mammals, such as humans and mice, the transmembrane regions were similar in IL-1R2 and IL-1R1 but only having a 28% homology in their extracellular domains (Dale and Nicklin, 1999). The structure of IL-1R2 is similar to that of IL-1R1, which includes a signal peptide, 3 Ig-like extracellular domains, and a single helical transmembrane domain and cytoplasmic domain; however, the length of the cytoplasmic domain in IL-1R2 is shorter than that of IL-1R1, which is approximately 200 amino acids, critical to the TIR domain (Slack et al., 2000).
An impedimetric biosensor system based on disposable graphite paper electrodes: Detection of ST2 as a potential biomarker for cardiovascular disease in human serum
2021, Analytica Chimica ActaCitation Excerpt :According to the Human Gene Nomenclature Database, interleukin-1 receptor-like-1 (IL1R1) represents soluble ST2. IL1RL1-a is soluble ST2 receptor and IL1R1-b is ST2L [14]. ST2 genes are preferably expressed on activated Th2 cells instead of Th1 cells and play an important role in Th2 effector functions [15] characterized by elevated expression of IL-4, IL-5 and IL-13 cytokines [15–17].
ST2: Current status
2018, Indian Heart JournalCitation Excerpt :Interleukin-1 receptor-like-1 (IL1RL1) is the approved symbol for ST2 from the Human Gene Nomenclature Database. The gene is located on Chromosome 2.12 The protein product of ST2 gene encodes a membrane receptor of the interleukin-1 receptor family and a truncated soluble receptor that can be detected in human serum.2
Interleukin-1 receptor gene variants are associated with aggressive periodontitis in the Japanese
2014, Archives of Oral BiologyIL-1 receptor 2 (IL-1R2) and its role in immune regulation
2013, Brain, Behavior, and ImmunityPrognostic Value of sST2 in Heart Failure
2023, Journal of Clinical Medicine
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