Elsevier

Genomics

Volume 57, Issue 1, 1 April 1999, Pages 177-179
Genomics

Short Communication
Interleukin-1 Receptor Cluster: Gene Organization ofIL1R2, IL1R1, IL1RL2(IL-1Rrp2),IL1RL1(T1/ST2), andIL18R1(IL-1Rrp) on Human Chromosome 2q

https://doi.org/10.1006/geno.1999.5767Get rights and content

Abstract

The family of interleukin-1 receptor-like genes currently has six known members. We have constructed a contig of 10 overlapping human PAC clones that covers 530 kb and includes five of the six family members. The termini of the contig were mapped to the interval between D2S373 and D2S176 (chromosome 2q12) by radiation hybrid mapping. The contig contains the genes (cen → tel), in the order given, for the type II interleukin-1 (IL-1) receptor (IL1R2), the type I IL-1 receptor (IL1R1), the IL-1 receptor-related protein 2 (IL1RL2), T1/ST2/fit-1 (IL1RL1), and the IL-1 receptor-related protein 1, which has recently been shown to be a component of the IL-18 receptor (IL18R1). We show that all the genes are transcribed in the same direction, withIL1R2being transcribed toward the cluster. The only known family member that is absent from the human contig is the IL-1 receptor accessory protein gene (IL1RAP), which maps to 3q28.

Cited by (93)

  • Molecular and functional characterization of chicken interleukin 1 receptor 2 (chIL-1R2)

    2023, Poultry Science
    Citation Excerpt :

    Recently, the family of decoy receptors has been identified and characterized as IL-18, TNF, and IL-27 (Mantovani et al., 2001). In mammals, such as humans and mice, the transmembrane regions were similar in IL-1R2 and IL-1R1 but only having a 28% homology in their extracellular domains (Dale and Nicklin, 1999). The structure of IL-1R2 is similar to that of IL-1R1, which includes a signal peptide, 3 Ig-like extracellular domains, and a single helical transmembrane domain and cytoplasmic domain; however, the length of the cytoplasmic domain in IL-1R2 is shorter than that of IL-1R1, which is approximately 200 amino acids, critical to the TIR domain (Slack et al., 2000).

  • An impedimetric biosensor system based on disposable graphite paper electrodes: Detection of ST2 as a potential biomarker for cardiovascular disease in human serum

    2021, Analytica Chimica Acta
    Citation Excerpt :

    According to the Human Gene Nomenclature Database, interleukin-1 receptor-like-1 (IL1R1) represents soluble ST2. IL1RL1-a is soluble ST2 receptor and IL1R1-b is ST2L [14]. ST2 genes are preferably expressed on activated Th2 cells instead of Th1 cells and play an important role in Th2 effector functions [15] characterized by elevated expression of IL-4, IL-5 and IL-13 cytokines [15–17].

  • ST2: Current status

    2018, Indian Heart Journal
    Citation Excerpt :

    Interleukin-1 receptor-like-1 (IL1RL1) is the approved symbol for ST2 from the Human Gene Nomenclature Database. The gene is located on Chromosome 2.12 The protein product of ST2 gene encodes a membrane receptor of the interleukin-1 receptor family and a truncated soluble receptor that can be detected in human serum.2

  • Prognostic Value of sST2 in Heart Failure

    2023, Journal of Clinical Medicine
View all citing articles on Scopus
1

To whom correspondence should be addressed. Telephone: +44 114 271 3261. Fax: +44 114 272 1104. E-mail:[email protected].

View full text