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The IGF-I Receptor in Cancer Research☆

https://doi.org/10.1006/excr.1999.4667Get rights and content

Abstract

The type 1 insulin-like growth factor receptor (IGF-IR) plays an important role in both normal and abnormal growth. It is particularly important in anchorage-independent growth. Impairment of its function causes apoptosis of tumor cells and inhibition of tumor growth in experimental animals. However, the IGF-IR can also induce differentiation, and eventually cell death, of certain types of cells. Its major substrates, IRS-1 and Shc, determine whether the IGF-IR will transform cells or will cause their differentiation.

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    ☆

    This work was supported by Grants CA53484 and CA56309 from the National Institutes of Health.

    2

    Correspondence and reprint requests may be addressed to the author at the above address. Fax: (215) 923-0249. E-mail: [email protected].

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