Biochemical and Biophysical Research Communications
Volume 280, Issue 3, 26 January 2001, Pages 874-877
Regular ArticleSimvastatin Promotes Osteoblast Differentiation and Mineralization in MC3T3-E1 Cells
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The effect of simvastatin-loaded methoxy poly(ethylene glycol)-polylactic acid nanoparticles on osteoblasts
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2021, International Journal of Biological MacromoleculesCitation Excerpt :Mundy et al. reported that SIM could enhance bone formation [22,31]. SIM was also shown to promote the osteogenic differentiation and mineralization of MC3T3-E1 cells, upregulate the expression of BMP-2 in osteoblasts and enhance the osteogenic capacity in bone defect sites [29,32,33]. Moreover, SIM can promote angiogenesis through upregulating the secretion of VEGF and the basic fibroblast growth factor (bFGF) [10,34].
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To whom correspondence should be addressed at Department of Biochemistry, Ohu University School of Dentistry, Koriyama 963-8611, Japan. Fax: (81)-24-938-9192. E-mail: [email protected].
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