nude mice

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Ultra-low Concentrations of Cisplatinum Down to the IC₁₀ in Combination With Recombinant Methioninase Are Synergistically Effective Against Lung Cancer Cells In Vitro and In Vivo
YOHEI ASANO, QINGHONG HAN, SHUKUAN LI, BYUNG MO KANG, JIN SOO KIM, YUTA MIYASHI, MICHAEL BOUVET, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, SEI MORINAGA, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

In Vivo March 2026, 40 (2) 803-812; DOI: https://doi.org/10.21873/invivo.14238
Open Access
HT1080 Human Fibrosarcoma Cells Selected for Super-eribulin Resistance In Vitro Become More Malignant and Are Arrested Synergistically by Methionine Restriction in Combination With Eribulin in Nude Mice
SEI MORINAGA, KOHEI MIZUTA, BYUNG MO KANG, QINGHONG HAN, MICHAEL BOUVET, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

In Vivo May 2025, 39 (3) 1275-1282; DOI: https://doi.org/10.21873/invivo.13931
Open Access
The Combination of Tumor-targeting Salmonella typhimurium A1-R Plus the Autophagy-inhibitor Chloroquine Synergistically Eradicates HT1080 Fibrosarcoma Cells In Vitro and In Vivo
SEI MORINAGA, MING ZHAO, KOHEI MIZUTA, BYUNG MO KANG, MICHAEL BOUVET, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

In Vivo January 2025, 39 (1) 102-109; DOI: https://doi.org/10.21873/invivo.13807
Open Access
Accurate and Safe Tumor Targeting of Orally-administered Salmonella typhimurium A1-R Leads to Regression of an Aggressive Fibrosarcoma in Nude Mice
SEI MORINAGA, MING ZHAO, KOHEI MIZUTA, BYUNG MO KANG, MOTOKAZU SATO, MICHAEL BOUVET, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

In Vivo November 2024, 38 (6) 2601-2609; DOI: https://doi.org/10.21873/invivo.13736
Open Access
Targeting Methionine Addiction Combined With Low-dose Irinotecan Arrested Colon Cancer in Contrast to High-dose Irinotecan Alone, Which Was Ineffective, in a Nude-mouse Model
MOTOKAZU SATO, KOHEI MIZUTA, QINGHONG HAN, SEI MORINAGA, BYUNG MO KANG, YUTARO KUBOTA, RYOSUKE MORI, ANTON BARANOV, KEITA KOBAYASHI, DANIEL ARDJMAND, NORITOSHI KOBAYASHI, MICHAEL BOUVET, YASUSHI ICHIKAWA, ATSUSHI NAKAJIMA and ROBERT M. HOFFMAN

In Vivo May 2024, 38 (3) 1058-1063; DOI: https://doi.org/10.21873/invivo.13539
Open Access
Precise and Facile Endotracheal Lung-tumor-implantation Mouse Model Visualized by GFP Expression
YUSUKE AOKI, KEITA J. KOBAYASHI, NUNDINI VARSHNEY, YUTARO KUBOTA, NORIYUKI MASAKI, KOYA OBARA, JUSTIN D. WANG, YASUNORI TOME, MICHAEL BOUVET, KOTARO NISHIDA and ROBERT M. HOFFMAN

In Vivo July 2023, 37 (4) 1477-1481; DOI: https://doi.org/10.21873/invivo.13231
Open Access
Oral-recombinant Methioninase Lowers the Effective Dose and Eliminates Toxicity of Cisplatinum for Primary Osteosarcoma of the Mammary Gland in a Patient-derived Orthotopic Xenograft Mouse Model
NORIYUKI MASAKI, QINGHONG HAN, NATHANIEL F. WU, CARISSA SAMONTE, JUSTIN WU, CHIHIRO HOZUMI, KOYA OBARA, YUTARO KUBOTA, YUSUKE AOKI, JUN MIYAZAKI and ROBERT M. HOFFMAN

In Vivo November 2022, 36 (6) 2598-2603; DOI: https://doi.org/10.21873/invivo.12994
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A Non-invasive Imageable GFP-expressing Mouse Model of Orthotopic Human Bladder Cancer
YU SUN, HIROTO NISHINO, MING ZHAO, KENTARO MIYAKE, NORIHIKO SUGISAWA, JUN YAMAMOTO, YOSHIHIKO TASHIRO, SACHIKO INUBUSHI, KAZUYUKI HAMADA, GUANGWEI ZHU, HYEIN LIM and ROBERT M. HOFFMAN

In Vivo November 2020, 34 (6) 3225-3231; DOI: https://doi.org/10.21873/invivo.12158
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Co-implantation of Tumor and Extensive Surrounding Tissue Improved the Establishment Rate of Surgical Specimens of Human-Patient Cancer in Nude Mice: Toward the Goal of Universal Individualized Cancer Therapy
TAKUYA MURATA, CHIHIRO HOZUMI, YUKIHIKO HIROSHIMA, KOICHIRO SHIMOYA, ATSUSHI HONGO, SACHIKO INUBUSHI, HIROKAZU TANINO and ROBERT M. HOFFMAN

In Vivo November 2020, 34 (6) 3241-3245; DOI: https://doi.org/10.21873/invivo.12160
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Humanized Fluorescent Tumor-associated Glycoprotein-72 Antibody Selectively Labels Colon-cancer Liver Metastases in Orthotopic Mouse Models
HANNAH M. HOLLANDSWORTH, HIROTO NISHINO, MICHAEL TURNER, SIAMAK AMIRFAKHRI, FILEMONI FILEMONI, ROBERT M. HOFFMAN, PAUL J. YAZAKI and MICHAEL BOUVET

In Vivo September 2020, 34 (5) 2303-2307; DOI: https://doi.org/10.21873/invivo.12042

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