methionine restriction

Open Access
Ultra-low Concentrations of Cisplatinum Down to the IC₁₀ in Combination With Recombinant Methioninase Are Synergistically Effective Against Lung Cancer Cells In Vitro and In Vivo
YOHEI ASANO, QINGHONG HAN, SHUKUAN LI, BYUNG MO KANG, JIN SOO KIM, YUTA MIYASHI, MICHAEL BOUVET, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, SEI MORINAGA, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

In Vivo March 2026, 40 (2) 803-812; DOI: https://doi.org/10.21873/invivo.14238
Open Access
HT1080 Human Fibrosarcoma Cells Selected for Super-eribulin Resistance In Vitro Become More Malignant and Are Arrested Synergistically by Methionine Restriction in Combination With Eribulin in Nude Mice
SEI MORINAGA, KOHEI MIZUTA, BYUNG MO KANG, QINGHONG HAN, MICHAEL BOUVET, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

In Vivo May 2025, 39 (3) 1275-1282; DOI: https://doi.org/10.21873/invivo.13931
Open Access
HT1080 Fibrosarcoma With Acquired Trabectedin Resistance: Increased Malignancy But Sustained Sensitivity to Methionine Restriction
SEI MORINAGA, QINGHONG HAN, KOHEI MIZUTA, BYUNG MO KANG, MICHAEL BOUVET, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

In Vivo March 2025, 39 (2) 683-690; DOI: https://doi.org/10.21873/invivo.13872
Open Access
Synergistic Eradication of Fibrosarcoma With Acquired Ifosfamide Resistance Using Methionine Restriction Combined With Ifosfamide in Nude-mouse Models
SEI MORINAGA, QINGHONG HAN, KOHEI MIZUTA, BYUNG MO KANG, MICHAEL BOUVET, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

In Vivo January 2025, 39 (1) 120-126; DOI: https://doi.org/10.21873/invivo.13809
Open Access
Extensive Shrinkage and Long-term Stable Disease in a Teenage Female Patient With High-grade Glioma Treated With Temozolomide and Radiation in Combination With Oral Recombinant Methioninase and a Low-methionine Diet
MOTOKAZU SATO, QINGHONG HAN, KOHEI MIZUTA, RYOSUKE MORI, BYUNG MO KANG, SEI MORINAGA, NORITOSHI KOBAYASHI, YASUSHI ICHIKAWA, ATSUSHI NAKAJIMA and ROBERT M. HOFFMAN

In Vivo May 2024, 38 (3) 1459-1464; DOI: https://doi.org/10.21873/invivo.13591
Open Access
Targeting Methionine Addiction Combined With Low-dose Irinotecan Arrested Colon Cancer in Contrast to High-dose Irinotecan Alone, Which Was Ineffective, in a Nude-mouse Model
MOTOKAZU SATO, KOHEI MIZUTA, QINGHONG HAN, SEI MORINAGA, BYUNG MO KANG, YUTARO KUBOTA, RYOSUKE MORI, ANTON BARANOV, KEITA KOBAYASHI, DANIEL ARDJMAND, NORITOSHI KOBAYASHI, MICHAEL BOUVET, YASUSHI ICHIKAWA, ATSUSHI NAKAJIMA and ROBERT M. HOFFMAN

In Vivo May 2024, 38 (3) 1058-1063; DOI: https://doi.org/10.21873/invivo.13539
Open Access
Methionine Dependence of Hair Maintenance in C57BL/6 Mice
YUTARO KUBOTA, NUNDINI VARSHNEY, KEITA KOBAYASHI, TAKUYA TSUNODA and ROBERT M. HOFFMAN

In Vivo May 2024, 38 (3) 1199-1202; DOI: https://doi.org/10.21873/invivo.13555
Open Access
[¹¹C] Methionine-PET Imaging as a Cancer Biomarker for Methionine Addiction and Sensitivity to Methionine-restriction-based Combination Chemotherapy
YUTARO KUBOTA, TOSHIHIKO SATO, QINGHONG HAN, CHIHIRO HOZUMI, SEI MORINAGA, KOHEI MIZUTA, TAKUYA TSUNODA and ROBERT M. HOFFMAN

In Vivo January 2024, 38 (1) 253-258; DOI: https://doi.org/10.21873/invivo.13432
Open Access
Rapid Reduction of CEA and Stable Metastasis in an NRAS-mutant Rectal-Cancer Patient Treated With FOLFIRI and Bevacizumab Combined With Oral Recombinant Methioninase and a Low-Methionine Diet Upon Metastatic Recurrence After FOLFIRI and Bevacizumab Treatment Alone
YUTARO KUBOTA, QINGHONG HAN, SEI MORINAGA, TAKUYA TSUNODA and ROBERT M. HOFFMAN

In Vivo September 2023, 37 (5) 2134-2138; DOI: https://doi.org/10.21873/invivo.13310
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Oral Methioninase for Covid-19 Methionine-restriction Therapy
ROBERT M. HOFFMAN and QINGHONG HAN

In Vivo June 2020, 34 (3 suppl) 1593-1596; DOI: https://doi.org/10.21873/invivo.11948

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