methionine addiction

Open Access
The Phosphatidylinositol 3-Kinase (PI3K) Inhibitor Inavolisib Has Breast-cancer Synergy Combined With Recombinant Methioninase But Not on Normal Cells
JINSOO KIM, QINGHONG HAN, SHUKUAN LI, YUTA MIYASHI, TOMOYUKI ISHIGURO, MICHAEL BOUVET and ROBERT M. HOFFMAN

In Vivo September 2026, 40 (5) 2663-2669; DOI: https://doi.org/10.21873/invivo.14420
Open Access
Synergy of a Low-methionine Diet and Reduced-dose Cisplatinum Eradicates Experimental Lung-cancer Bone Metastases in a Nude-mouse Model
YOHEI ASANO, KOHEI MIZUTA, YUTA MIYASHI, QINGHONG HAN, SHUKUAN LI, BYUNG MO KANG, JIN SOO KIM, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, SEI MORINAGA, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

In Vivo July 2026, 40 (4) 1979-1986; DOI: https://doi.org/10.21873/invivo.14350
Open Access
Ultra-low Concentrations of Cisplatinum Down to the IC₁₀ in Combination With Recombinant Methioninase Are Synergistically Effective Against Lung Cancer Cells In Vitro and In Vivo
YOHEI ASANO, QINGHONG HAN, SHUKUAN LI, BYUNG MO KANG, JIN SOO KIM, YUTA MIYASHI, MICHAEL BOUVET, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, SEI MORINAGA, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

In Vivo March 2026, 40 (2) 803-812; DOI: https://doi.org/10.21873/invivo.14238
Open Access
Methionine Restriction Alone Induces T-cell-mediated Immunotherapy of Osteosarcoma in a Syngeneic Mouse Model
KOHEI MIZUTA, YUTARO KUBOTA, YUSUKE AOKI, SEI MORINAGA, YOHEI ASANO, YUTA MIYASHI, MICHAEL BOUVET, YASUNORI TOME, KOTARO NISHIDA and ROBERT M. HOFFMAN

In Vivo March 2026, 40 (2) 813-825; DOI: https://doi.org/10.21873/invivo.14239
Open Access
HT1080 Human Fibrosarcoma Cells Selected for Super-eribulin Resistance In Vitro Become More Malignant and Are Arrested Synergistically by Methionine Restriction in Combination With Eribulin in Nude Mice
SEI MORINAGA, KOHEI MIZUTA, BYUNG MO KANG, QINGHONG HAN, MICHAEL BOUVET, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

In Vivo May 2025, 39 (3) 1275-1282; DOI: https://doi.org/10.21873/invivo.13931
Open Access
HT1080 Fibrosarcoma With Acquired Trabectedin Resistance: Increased Malignancy But Sustained Sensitivity to Methionine Restriction
SEI MORINAGA, QINGHONG HAN, KOHEI MIZUTA, BYUNG MO KANG, MICHAEL BOUVET, NORIO YAMAMOTO, KATSUHIRO HAYASHI, HIROAKI KIMURA, SHINJI MIWA, KENTARO IGARASHI, TAKASHI HIGUCHI, HIROYUKI TSUCHIYA, SATORU DEMURA and ROBERT M. HOFFMAN

In Vivo March 2025, 39 (2) 683-690; DOI: https://doi.org/10.21873/invivo.13872
Open Access
Extensive Shrinkage and Long-term Stable Disease in a Teenage Female Patient With High-grade Glioma Treated With Temozolomide and Radiation in Combination With Oral Recombinant Methioninase and a Low-methionine Diet
MOTOKAZU SATO, QINGHONG HAN, KOHEI MIZUTA, RYOSUKE MORI, BYUNG MO KANG, SEI MORINAGA, NORITOSHI KOBAYASHI, YASUSHI ICHIKAWA, ATSUSHI NAKAJIMA and ROBERT M. HOFFMAN

In Vivo May 2024, 38 (3) 1459-1464; DOI: https://doi.org/10.21873/invivo.13591
Open Access
Targeting Methionine Addiction Combined With Low-dose Irinotecan Arrested Colon Cancer in Contrast to High-dose Irinotecan Alone, Which Was Ineffective, in a Nude-mouse Model
MOTOKAZU SATO, KOHEI MIZUTA, QINGHONG HAN, SEI MORINAGA, BYUNG MO KANG, YUTARO KUBOTA, RYOSUKE MORI, ANTON BARANOV, KEITA KOBAYASHI, DANIEL ARDJMAND, NORITOSHI KOBAYASHI, MICHAEL BOUVET, YASUSHI ICHIKAWA, ATSUSHI NAKAJIMA and ROBERT M. HOFFMAN

In Vivo May 2024, 38 (3) 1058-1063; DOI: https://doi.org/10.21873/invivo.13539
Open Access
[¹¹C] Methionine-PET Imaging as a Cancer Biomarker for Methionine Addiction and Sensitivity to Methionine-restriction-based Combination Chemotherapy
YUTARO KUBOTA, TOSHIHIKO SATO, QINGHONG HAN, CHIHIRO HOZUMI, SEI MORINAGA, KOHEI MIZUTA, TAKUYA TSUNODA and ROBERT M. HOFFMAN

In Vivo January 2024, 38 (1) 253-258; DOI: https://doi.org/10.21873/invivo.13432
Open Access
Rapid Reduction of CEA and Stable Metastasis in an NRAS-mutant Rectal-Cancer Patient Treated With FOLFIRI and Bevacizumab Combined With Oral Recombinant Methioninase and a Low-Methionine Diet Upon Metastatic Recurrence After FOLFIRI and Bevacizumab Treatment Alone
YUTARO KUBOTA, QINGHONG HAN, SEI MORINAGA, TAKUYA TSUNODA and ROBERT M. HOFFMAN

In Vivo September 2023, 37 (5) 2134-2138; DOI: https://doi.org/10.21873/invivo.13310

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