RT Journal Article
SR Electronic
T1 Comparison of Weight and Body Composition After Gastrectomy Between Elderly and Non-elderly Patients With Gastric Cancer
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 221
OP 227
DO 10.21873/invivo.11463
VO 33
IS 1
A1 TORU AOYAMA
A1 YUKIO MAEZAWA
A1 TAKAKI YOSHIKAWA
A1 KENKI SEGAMI
A1 KAZUKI KANO
A1 TSUTOMU HAYASHI
A1 TAKANOBU YAMADA
A1 MASAKATSU NUMATA
A1 MOTOHICO GODA
A1 HIROSHI TAMAGAWA
A1 TSUTOMU SATO
A1 NORIO YUKAWA
A1 YASUSHI RINO
A1 MUNETAKA MASUDA
A1 TAKASHI OGATA
A1 HARUHIKO CHO
A1 TAKASHI OSHIMA
YR 2019
UL http://iv.iiarjournals.org/content/33/1/221.abstract
AB Background: Body weight, especially lean body mass, significantly decreases after gastrectomy for gastric cancer due to surgical invasion, reduced food intake, and reduced mobility, which can reduce the quality of life and induce associated toxicity or reduce compliance with adjuvant chemotherapy. Such risks can be particularly high in elderly patients with gastric cancer. However, whether or not changes in the weight and body composition differ between elderly and non-elderly patients remains unclear. Patients and Methods: This retrospective study examined patients who underwent curative surgery for gastric cancer between May 2010 and February 2017. Body weight and composition were evaluated by a bioelectrical impedance analyzer within 1 week before surgery, at 1 week after surgery, and at 1 and at 3 months after surgery. Patients were classified as elderly (≥80 years) or non-elderly (<80 years). Results: Eight-hundred and eighty-eight patients (84 elderly and 804 non-elderly) were entered into the present study. Patient background, surgical and clinicopathological factors, and surgical complications did not significantly differ between the two groups. Body weight loss at 1 week, and at 1 and 3 months after surgery, defined as the decrease from the preoperative value, were −2.8%, −6.5%, and −9.0%, respectively, in the elderly and −3.5%, −6.0%, and −8.1%, respectively, in the non-elderly patients (p=0.111, 0.125, and 0.153, respectively). The corresponding losses of lean body mass were −2.6%, −6.0%, and −6.4%, respectively, in the elderly and −3.5%, −4.9%, and −4.7%, respectively, in the non-elderly patients, with p-values of 0.056, 0.036, and 0.029, respectively. Conclusion: Decreases in lean body mass after gastrectomy were greater in elderly than in non-elderly patients. In order to maintain lean body mass among elderly patients, additional care and treatments are needed.