RT Journal Article
SR Electronic
T1 Virome Analysis Reveals No Association of Head and Neck Vascular Anomalies with an Active Viral Infection
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 1323
OP 1331
DO 10.21873/invivo.11382
VO 32
IS 6
A1 NORA FRANKE
A1 MICHAEL BETTE
A1 ANDRÉ MARQUARDT
A1 THOMAS BRIESE
A1 W. IAN LIPKIN
A1 CHRISTOPHER KURZ
A1 JOVINE EHRENREICH
A1 ELISABETH MACK
A1 BIANKA BAYING
A1 VLADIMIR BENEŠ
A1 FIONA R. RODEPETER
A1 ANDREAS NEFF
A1 AFSHIN TEYMOORTASH
A1 BEHFAR EIVAZI
A1 URBAN GEISTHOFF
A1 BORIS A. STUCK
A1 UDO BAKOWSKY
A1 ROBERT MANDIC
YR 2018
UL http://iv.iiarjournals.org/content/32/6/1323.abstract
AB Background/Aim: Vascular anomalies encompass different vascular malformations [arteriovenous (AVM), lymphatic (LM), venous lymphatic (VLM), venous (VM)] and vascular tumors such as hemangiomas (HA). The pathogenesis of vascular anomalies is still poorly understood. Viral infection was speculated as a possible underlying cause. Materials and Methods: A total of 13 human vascular anomalies and three human skin control tissues were used for viral analysis. RNA derived from AVM (n=4) and normal skin control (n=3) tissues was evaluated by RNA sequencing. The Virome Capture Sequencing Platform for Vertebrate Viruses (VirCapSeq-VERT) was deployed on 10 tissues with vascular anomalies (2×AVM, 1×HA, 1×LM, 2×VLM, 4×VM). Results: RNA sequencing did not show any correlation of AVM with viral infection. By deploying VirCapSeq-VERT, no consistent viral association was seen in the tested tissues. Conclusion: The analysis does not point to the presence of an active viral infection in vascular anomalies. However, transient earlier viral infections, e.g. during pregnancy, cannot be excluded with this approach.