RT Journal Article
SR Electronic
T1 Potential Prognostic Factors of Downstaging Following Preoperative Chemoradiation for High Rectal Cancer
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 1481
OP 1484
DO 10.21873/invivo.11403
VO 32
IS 6
A1 MAXI TREDER
A1 RASMUS PEULICHE VOGELSANG
A1 STEFAN JANSSEN
A1 STEVEN E. SCHILD
A1 NIELS HENRIK HOLLÄNDER
A1 DIRK RADES
YR 2018
UL http://iv.iiarjournals.org/content/32/6/1481.abstract
AB Background/Aim: Treatment for high rectal cancers, particularly the value of preoperative treatment, is controversial. In our previous study, downstaging by preoperative chemoradiation resulted in improved outcomes. The aim of the present study was to identify prognostic factors to predict which patients will achieve downstaging and may benefit from preoperative treatment. Patients and Methods: In 54 patients with locally advanced non-metastatic high rectal cancer, 8 factors were evaluated for downstaging by preoperative chemoradiation including age, gender, carcinoembryonic antigen level, performance status, T-/N-category, UICC-stage (Union for International Cancer Control) and histological grade. Downstaging was defined as decrease by at least one UICC-stage. Results: Downstaging was achieved in 36 patients (67%). Patients at UICC-stage III showed a trend for downstaging. Conclusion: The majority of patients with UICC-stage III tumors were downstaged and appear to benefit from preoperative chemoradiation. In general, the potential value of preoperative treatment for high rectal cancers needs further investigation.